Endothelin converting enzyme 1

mammalian protein found in Homo sapiens
Protein Protein Q22677862

Facts

9 properties
Instance of
protein
Part of
Metallopeptidase, catalytic domain superfamily, membrane protein, Peptidase M13, C-terminal domain, protein family, Peptidase M13, N-terminal domain, protein family[1][2][3][4]
Biological process
endothelin maturation, bradykinin catabolic process, regulation of systemic arterial blood pressure by endothelin, embryonic digit morphogenesis, ear development, hormone catabolic process, proteolysis, development of the heart, calcitonin catabolic process, regulation of vasoconstriction, substance P catabolic process, pharyngeal system development, positive regulation of receptor recycling, protein processing, peptide hormone processing[30][31][32][33][34][35][36][37][38][39][40][41][42][43]
Cell component
Weibel-Palade body, integral component of membrane, vesicle, endosome, membrane, lysosomal membrane, intrinsic component of endosome membrane, perinuclear region of cytoplasm, extracellular exosome, external side of plasma membrane, early endosome, plasma membrane, lysosomal membrane, plasma membrane, membrane, extracellular exosome[18][19][20][21][22][23][24][25][26][27][28][29]
EC enzyme number
3.4.24.71[7]
Encoded by
ECE1[44]
Found in taxon
Homo sapiens[45]
Has part(s)
Peptidase M13, N-terminal domain, Peptidase M13, C-terminal domain[5][6]
Molecular function
endopeptidase activity, metal ion binding, peptide hormone binding, peptidase activity, protein binding, hydrolase activity, metallopeptidase activity, protein homodimerization activity, metalloendopeptidase activity, zinc ion binding[8][9][10][11][12][13][14][15][16][17]
🏷️ Also known as
en ECE-1 en ECE1 en endothelin-converting enzyme 1 en Endothelin converting enzyme 1 de Endothelin-konvertierendes Enzym

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🔗 Connections
Cell component 7
Biological process 2
Found in taxon 1
Instance of 1
Molecular function 1
Part of 1
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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [2] ↑ . wikidata.org.
  3. [3] ↑ . wikidata.org.
  4. [4] ↑ . wikidata.org.
  5. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [7] ↑ . UniProt. Retrieved . wikidata.org.
  8. [8] ↑ . Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [10] ↑ . Cloning and functional expression of human endothelin-converting enzyme cDNA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [12] ↑ . A proteome-scale map of the human interactome network. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . Structure of human endothelin-converting enzyme I complexed with phosphoramidon. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . Human endothelial cell storage granules: a novel intracellular site for isoforms of the endothelin-converting enzyme. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . Endothelin-converting enzyme: ultrastructural localization and its recycling from the cell surface. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . Integral and associated lysosomal membrane proteins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . Human endothelial cell storage granules: a novel intracellular site for isoforms of the endothelin-converting enzyme. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . Large-scale proteomics and phosphoproteomics of urinary exosomes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . Human endothelial cell storage granules: a novel intracellular site for isoforms of the endothelin-converting enzyme. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [30] ↑ . Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [31] ↑ . Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [32] ↑ . Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [33] ↑ . A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [34] ↑ . A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [35] ↑ . Cloning and functional expression of human endothelin-converting enzyme cDNA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [37] ↑ . A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [38] ↑ . Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [39] ↑ . Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [40] ↑ . Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [41] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  42. [42] ↑ . Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  43. [43] ↑ . Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  44. [44] ↑ . UniProt. Retrieved . wikidata.org.
  45. [45] ↑ . UniProt. Retrieved . wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Endothelin converting enzyme 1. Retrieved November 7, 2026, from https://4ort.xyz/entity/endothelin-converting-enzyme-1
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BibTeX @misc{4ortxyz_endothelin-converting-enzyme-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Endothelin converting enzyme 1}}, year = {2026}, url = {https://4ort.xyz/entity/endothelin-converting-enzyme-1}, note = {Accessed: 2026-11-07}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 15w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon → Homo sapiens
    Encoded by → ECE1
    Cell component → Weibel-Palade body, integral component of membrane, vesicle +13
    Part of → Metallopeptidase, catalytic domain superfamily, membrane protein, Peptidase M13, C-terminal domain, protein family +1
    + 5 other properties edited (see Wikidata diff for full list)
    "Created claim: EC enzyme number: 3.4.24.71, batch #261491"
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