endothelin 1
mammalian protein found in human, mouse, rat
Facts
9 properties- Part of
- Endothelin, G alpha (q) signalling events, ECE1 cleaves EDN1(53-90), EDNRA,EDNRB bind EDNs, Endothelin 1[3][4][5][6][7]
- Biological process
- skeletal system development, response to amino acid, positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway, positive regulation of MAP kinase activity, regulation of sensory perception of pain, vasoconstriction, body fluid secretion, positive regulation of sarcomere organization, positive regulation of cardiac muscle hypertrophy, cell surface receptor signaling pathway, multicellular organism aging, artery smooth muscle contraction, cellular response to interferon-gamma, positive regulation of chemokine-mediated signaling pathway, phosphatidylinositol 3-kinase signaling, response to leptin, positive regulation of mitotic nuclear division, cellular response to hypoxia, response to muscle stretch, cellular response to calcium ion, cellular response to transforming growth factor beta stimulus, positive regulation of renal sodium excretion, blood vessel morphogenesis, negative regulation of blood coagulation, response to nicotine, in utero embryonic development, neutrophil chemotaxis, development of the heart, positive regulation of prostaglandin secretion, vein smooth muscle contraction, cartilage development, rhythmic excitation, protein kinase C-activating G protein-coupled receptor signaling pathway, cellular response to glucocorticoid stimulus, branching involved in blood vessel morphogenesis, negative regulation of hormone secretion, positive regulation of smooth muscle contraction, negative regulation of nitric-oxide synthase biosynthetic process, positive regulation of prostaglandin-endoperoxide synthase activity, positive regulation of urine volume, positive regulation of JUN kinase activity, leukocyte activation, membrane depolarization, negative regulation of transcription by RNA polymerase II, response to ozone, respiratory gaseous exchange by respiratory system, positive regulation of heart rate, regulation of blood pressure, response to lipopolysaccharide, response to prostaglandin F, regulation of vasoconstriction, cellular response to interleukin-1, response to salt, positive regulation of cell size, middle ear morphogenesis, sensory perception of pain, prostaglandin biosynthetic process, dorsal/ventral pattern formation, phospholipase D-activating G protein-coupled receptor signaling pathway, positive regulation of odontogenesis, regulation of pH, positive regulation of smooth muscle cell proliferation, protein kinase C deactivation, histamine secretion, maternal process involved in parturition, intracellular signal transduction, response to hypoxia, neural crest cell development, regulation of systemic arterial blood pressure by endothelin, nitric oxide transport, positive regulation of cell migration, response to testosterone, positive regulation of cytosolic calcium ion concentration, epithelial fluid transport, positive regulation of nitric oxide biosynthetic process, cell-cell signaling, cellular response to tumor necrosis factor, response to activity, response to dexamethasone, superoxide anion generation, positive regulation of endothelial cell migration, cellular response to peptide hormone stimulus, cellular response to fatty acid, peptide hormone secretion, cellular response to mineralocorticoid stimulus, positive regulation of cell population proliferation, inositol phosphate-mediated signaling, positive regulation of hormone secretion, negative regulation of smooth muscle cell apoptotic process, calcium-mediated signaling, response to transforming growth factor beta, positive regulation of transcription by RNA polymerase II, positive regulation of DNA-binding transcription factor activity, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of neutrophil chemotaxis, regulation of signaling receptor activity, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, regulation of glucose transmembrane transport, negative regulation of gene expression, positive regulation of NIK/NF-kappaB signaling, positive regulation of vascular associated smooth muscle cell proliferation
- Cell component
- cytoplasm, Weibel-Palade body, basal part of cell, extracellular region, rough endoplasmic reticulum lumen, extracellular space, transport vesicle
- Encoded by
- EDN1
- Found in taxon
- Homo sapiens
- Has parts
- Endothelin-like toxin, Endothelin-like toxin, conserved site
- Molecular function
- hormone activity, signaling receptor binding, cytokine activity, endothelin B receptor binding, protein binding, endothelin A receptor binding
🏷️ Also known as
en ET-1
en ET1
en EDN1
en endothelin 1
en endothelin-1
ar الإندوتللين
de Endothelin
es Endotelina
fi Endoteliini
fr Endotheline
fr Endothéline
id Endotelin
it Endoteline
ja エンドセリン
pl Endoteliny
ru Эндотелин
ru Эндотелин 1
zh 內皮素
zh 內皮素-1
zh 内皮素-1
🔖 Identifiers · 16
- OpenAlex ID
- C149601957
- ChEBI ID
- 80240
- ChEMBL ID
- CHEMBL437472, CHEMBL3775234
- Exact match
- www.uniprot.org
- Freebase ID
- /m/07p9fc
- Gran Enciclopèdia Catalana ID
- endotelina
- Gran Enciclopèdia Catalana ID (former scheme)
- 0281914
- Guide to Pharmacology Ligand ID
- 989
- JSTOR topic ID (archived)
- endothelins
- MeSH descriptor ID
- D019332
- MeSH tree code
- D12.644.276.400.225, D12.776.467.400.225
- Microsoft Academic ID (discontinued)
- 149601957
Show all 16 identifiers +4
- Reactome ID
- R-HSA-388545, R-HSA-8878414
- RefSeq protein ID
- NP_001161791, NP_001946, XP_011512632, XP_011512633, XP_011512634, XP_016865820
- WikiSkripta article ID
- 62560
🔗 Connections
Biological process 4
Cell component 3
Found in taxon 1
Instance of 1
Molecular function 1
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Summary
endothelin 1 is a peptide[1].