Endoplasmic reticulum to nucleus signaling 1

mammalian protein found in Homo sapiens

Protein protein Q21115427

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Summary

Endoplasmic reticulum to nucleus signaling 1 is a protein^[1]. It is known by 12 alternative names across languages and contexts.^[2]

Key Facts

Endoplasmic reticulum to nucleus signaling 1's instance of is recorded as protein^[3].
Endoplasmic reticulum to nucleus signaling 1 is part of Quinoprotein alcohol dehydrogenase-like superfamily^[4].
Endoplasmic reticulum to nucleus signaling 1 is part of Protein kinase-like domain superfamily^[5].
Endoplasmic reticulum to nucleus signaling 1 is part of KEN domain superfamily^[6].
Endoplasmic reticulum to nucleus signaling 1 is part of WD40/YVTN repeat-like-containing domain superfamily^[7].
Endoplasmic reticulum to nucleus signaling 1 is part of KEN domain, protein family^[8].
Endoplasmic reticulum to nucleus signaling 1 is part of PUB domain, protein family^[9].
Endoplasmic reticulum to nucleus signaling 1 is part of Protein kinase domain, protein family^[10].
Endoplasmic reticulum to nucleus signaling 1 is part of Pyrrolo-quinoline quinone beta-propeller repeat, protein family^[11].
Endoplasmic reticulum to nucleus signaling 1 is part of Serine/threonine-protein kinase, active site, protein family^[12].
Endoplasmic reticulum to nucleus signaling 1 comprises Pyrrolo-quinoline quinone beta-propeller repeat^[13].
Endoplasmic reticulum to nucleus signaling 1 comprises KEN domain^[14].
Endoplasmic reticulum to nucleus signaling 1 comprises protein kinase domain^[15].
Endoplasmic reticulum to nucleus signaling 1 comprises serine/threonine-protein kinase, active site^[16].
Endoplasmic reticulum to nucleus signaling 1 comprises PUB domain^[17].
Endoplasmic reticulum to nucleus signaling 1's molecular function is recorded as metal ion binding^[18].
Endoplasmic reticulum to nucleus signaling 1's molecular function is recorded as nucleotide binding^[19].
Endoplasmic reticulum to nucleus signaling 1's molecular function is recorded as ADP binding^[20].
Endoplasmic reticulum to nucleus signaling 1's molecular function is recorded as ribonuclease activity^[21].
Endoplasmic reticulum to nucleus signaling 1's molecular function is recorded as identical protein binding^[22].
Endoplasmic reticulum to nucleus signaling 1's molecular function is recorded as protein kinase activity^[23].
Endoplasmic reticulum to nucleus signaling 1's molecular function is recorded as transferase activity^[24].
Endoplasmic reticulum to nucleus signaling 1's molecular function is recorded as magnesium ion binding^[25].
Endoplasmic reticulum to nucleus signaling 1's molecular function is recorded as hydrolase activity^[26].
Endoplasmic reticulum to nucleus signaling 1's molecular function is recorded as Hsp70 protein binding^[27].

Why It Matters

Endoplasmic reticulum to nucleus signaling 1 is known by 12 alternative names across languages and contexts.^[2]

⭐ Popularity Graph

1/100 established

Quick Facts

Instance of protein

Part of Quinoprotein alcohol dehydrogenase-like superfamily, Protein kinase-like domain superfamily, KEN domain superfamily, WD40/YVTN repeat-like-containing domain superfamily, KEN domain, protein family, PUB domain, protein family, Protein kinase domain, protein family, Pyrrolo-quinoline quinone beta-propeller repeat, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process positive regulation of endoplasmic reticulum unfolded protein response, mRNA catabolic process, transcription, DNA-templated, insulin metabolic process, peptidyl-serine autophosphorylation, cellular response to vascular endothelial growth factor stimulus, protein autophosphorylation, metabolism, apoptotic process, mRNA splicing, via endonucleolytic cleavage and ligation, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, cellular response to glucose stimulus, peptidyl-serine trans-autophosphorylation, protein phosphorylation, response to unfolded protein, mRNA processing, response to endoplasmic reticulum stress, regulation of transcription, DNA-templated, endothelial cell proliferation, regulation of macroautophagy, phosphorylation, endoplasmic reticulum unfolded protein response, positive regulation of vascular associated smooth muscle cell proliferation, RNA phosphodiester bond hydrolysis, endonucleolytic, positive regulation of RNA splicing, IRE1-mediated unfolded protein response, mRNA cleavage involved in mRNA processing, mRNA cleavage, Unfolded Protein Response, mRNA splicing, via endonucleolytic cleavage and ligation, endoplasmic reticulum unfolded protein response, IRE1-mediated unfolded protein response, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cell component AIP1-IRE1 complex, cytoplasm, integral component of membrane, mitochondrion, IRE1-TRAF2-ASK1 complex, IRE1-RACK1-PP2A complex, nuclear inner membrane, Ire1 complex, membrane, integral component of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum membrane, IRE1-TRAF2-ASK1 complex

Ec enzyme number 2.7.11.1

Encoded by ERN1

Found in taxon Homo sapiens

Has part(s) Pyrrolo-quinoline quinone beta-propeller repeat, KEN domain, protein kinase domain, serine/threonine-protein kinase, active site, PUB domain

Molecular function metal ion binding, nucleotide binding, ADP binding, ribonuclease activity, identical protein binding, protein kinase activity, transferase activity, magnesium ion binding, hydrolase activity, Hsp70 protein binding, kinase activity, Hsp90 protein binding, catalytic activity, endonuclease activity, ATP binding, enzyme binding, protein binding, endoribonuclease activity, protein serine/threonine kinase activity, platelet-derived growth factor receptor binding, protein homodimerization activity, endoribonuclease activity, protein kinase activity, protein serine/threonine kinase activity, unfolded protein binding, endoribonuclease activity, protein serine/threonine kinase activity

External References (4)

Ensembl protein id ENSP00000401445, ENSP00000475519

Pdb structure id 2HZ6, 3P23, 4U6R, 4Z7G, 4Z7H, 4YZC, 4YZ9, 4YZD, 5HGI

Refseq protein id NP_001424, XP_016879836, XP_016879837

Uniprot protein id O75460

🏷️ Also known as

en Endoplasmic reticulum to nucleus signaling 1 en Endoplasmic reticulum-to-nucleus signaling 1 en ERN1 en ER to nucleus signalling 1 en hIRE1p en inositol-requiring 1 en inositol-requiring enzyme 1 en inositol-requiring protein 1 en IRE1a en ire1-alpha en protein kinase/endoribonuclease en serine/threonine-protein kinase/endoribonuclease IRE1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Endoplasmic reticulum to nucleus signaling 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/endoplasmic-reticulum-to-nucleus-signaling-1

MLA

“Endoplasmic reticulum to nucleus signaling 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/endoplasmic-reticulum-to-nucleus-signaling-1.

BibTeX

@misc{4ortxyz_endoplasmic-reticulum-to-nucleus-signaling-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Endoplasmic reticulum to nucleus signaling 1}}, year = {2026}, url = {https://4ort.xyz/entity/endoplasmic-reticulum-to-nucleus-signaling-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Endoplasmic reticulum to nucleus signaling 1 — https://4ort.xyz/entity/endoplasmic-reticulum-to-nucleus-signaling-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/endoplasmic-reticulum-to-nucleus-signaling-1 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

13w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → ERN1

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → metal ion binding, nucleotide binding, ADP binding +24

+ 11 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ Ec enzyme number: 2.7.11.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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