Ectonucleotide pyrophosphatase/phosphodiesterase 3

mammalian protein found in Homo sapiens
Protein protein Q21110156
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Summary

Ectonucleotide pyrophosphatase/phosphodiesterase 3 is a protein[1]. It is known by 11 alternative names across languages and contexts.[2]

Key Facts

  • Part of: Somatomedin B-like domain superfamily[3], Alkaline-phosphatase-like, core domain superfamily[4], Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase[5], Somatomedin B[6], Extracellular Endonuclease, subunit A, protein family[7], DNA/RNA non-specific endonuclease family[8]
  • Has part(s): DNA/RNA non-specific endonuclease[9], Extracellular Endonuclease, subunit A[10], Somatomedin B domain[11]
  • Molecular function: nucleoside-triphosphate diphosphatase activity[12], nucleotide diphosphatase activity[13], phosphodiesterase I activity[14], polysaccharide binding[15], metal ion binding[16], scavenger receptor activity[17], NADH pyrophosphatase activity[18], catalytic activity[19], nucleic acid binding[20], hydrolase activity[21], calcium ion binding[22], zinc ion binding[23]
  • Cell component: integral component of membrane[24], membrane[25], integral component of plasma membrane[26], extracellular region[27], perinuclear region of cytoplasm[28], extracellular exosome[29], plasma membrane[30], external side of plasma membrane[31], apical plasma membrane[32]
  • Biological process: nucleoside triphosphate catabolic process[33], receptor-mediated endocytosis[34], immune response[35], phosphate-containing compound metabolic process[36], metabolism[37], inorganic diphosphate transport[38], nucleic acid phosphodiester bond hydrolysis[39], basophil activation involved in immune response[40], pyrimidine nucleotide metabolic process[41], negative regulation of mast cell activation involved in immune response[42], ATP metabolic process[43], negative regulation of inflammatory response[44], negative regulation of mast cell proliferation[45], vesicle-mediated transport[46]
  • Encoded by: ENPP3[47]
  • Found in taxon: Homo sapiens[48]
  • Exact match: https://identifiers.org/uniprot:O14638[49], http://purl.uniprot.org/uniprot/O14638[50], https://www.ncbi.nlm.nih.gov/protein/O14638[51]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . Molecular Cloning and Chromosomal Localization of PD-Iβ (PDNP3), a New Member of the Human Phosphodiesterase I Genes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . Molecular Cloning and Chromosomal Localization of PD-Iβ (PDNP3), a New Member of the Human Phosphodiesterase I Genes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . Structural basis for nucleotide recognition by the ectoenzyme CD203c. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . Structural basis for nucleotide recognition by the ectoenzyme CD203c. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . Molecular Cloning and Chromosomal Localization of PD-Iβ (PDNP3), a New Member of the Human Phosphodiesterase I Genes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . Large-scale proteomics and phosphoproteomics of urinary exosomes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [41] ↑ . The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [42] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [43] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  42. [44] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  43. [45] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  44. [46] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  45. [47] ↑ . UniProt. Retrieved . wikidata.org.
  46. [48] ↑ . UniProt. Retrieved . wikidata.org.
  47. [49] ↑ . Identifiers.org. registry.identifiers.org. Provenance: wikidata.org.
  48. [50] ↑ . Identifiers.org. registry.identifiers.org. Provenance: wikidata.org.
  49. [51] ↑ . Identifiers.org. registry.identifiers.org. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Ectonucleotide pyrophosphatase/phosphodiesterase 3. Retrieved October 15, 2026, from https://4ort.xyz/entity/ectonucleotide-pyrophosphatase-phosphodiesterase-3
MLA “Ectonucleotide pyrophosphatase/phosphodiesterase 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 15 Oct. 2026, https://4ort.xyz/entity/ectonucleotide-pyrophosphatase-phosphodiesterase-3.
BibTeX @misc{4ortxyz_ectonucleotide-pyrophosphatase-phosphodiesterase-3_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Ectonucleotide pyrophosphatase/phosphodiesterase 3}}, year = {2026}, url = {https://4ort.xyz/entity/ectonucleotide-pyrophosphatase-phosphodiesterase-3}, note = {Accessed: 2026-10-15}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → ENPP3
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → nucleoside-triphosphate diphosphatase activity, nucleotide diphosphatase activity, phosphodiesterase I activity +12
    + 12 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 3.1.4.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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