Ectonucleotide pyrophosphatase/phosphodiesterase 1

mammalian protein found in Homo sapiens
Protein protein Q21110158
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Summary

Ectonucleotide pyrophosphatase/phosphodiesterase 1 is a protein[1]. It draws 68 Wikipedia views per month (protein category, ranking #153 of 987).[2]

Key Facts

  • Part of: Somatomedin B-like domain superfamily[3], Alkaline-phosphatase-like, core domain superfamily[4], Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase[5], Somatomedin B, chordata, protein family[6], Somatomedin B[7], Extracellular Endonuclease, subunit A, protein family[8], DNA/RNA non-specific endonuclease family[9]
  • Has part(s): DNA/RNA non-specific endonuclease[10], Somatomedin B, chordata[11], Extracellular Endonuclease, subunit A[12], Somatomedin B domain[13]
  • EC enzyme number: 3.1.4.1[14], 3.6.1.9[15]
  • Molecular function: nucleoside-triphosphate diphosphatase activity[16], calcium ion binding[17], nucleotide diphosphatase activity[18], protein homodimerization activity[19], insulin receptor binding[20], zinc ion binding[21], polysaccharide binding[22], 3'-phosphoadenosine 5'-phosphosulfate binding[23], metal ion binding[24], scavenger receptor activity[25], NADH pyrophosphatase activity[26], protein binding[27], catalytic activity[28], nucleic acid binding[29]
  • Cell component: integral component of membrane[30], membrane[31], plasma membrane[32], integral component of plasma membrane[33], extracellular region[34], cell surface[35], lysosomal membrane[36], basolateral plasma membrane[37], extracellular space[38]
  • Biological process: negative regulation of fat cell differentiation[39], negative regulation of protein autophosphorylation[40], regulation of bone mineralization[41], riboflavin metabolic process[42], biomineral tissue development[43], nucleoside triphosphate catabolic process[44], cellular phosphate ion homeostasis[45], negative regulation of glycogen biosynthetic process[46], receptor-mediated endocytosis[47], generation of precursor metabolites and energy[48], 3'-phosphoadenosine 5'-phosphosulfate metabolic process[49], negative regulation of glucose import[50], negative regulation of insulin receptor signaling pathway[51], negative regulation of cell growth[52]

Why It Matters

Ectonucleotide pyrophosphatase/phosphodiesterase 1 is known by 14 alternative names across languages and contexts.[53]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . wikidata.org.
  2. [4] ↑ . wikidata.org.
  3. [5] ↑ . wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . wikidata.org.
  8. [10] ↑ . wikidata.org.
  9. [11] ↑ . wikidata.org.
  10. [12] ↑ . wikidata.org.
  11. [13] ↑ . wikidata.org.
  12. [14] ↑ . wikidata.org.
  13. [15] ↑ . wikidata.org.
  14. [16] ↑ . wikidata.org.
  15. [17] ↑ . wikidata.org.
  16. [18] ↑ . wikidata.org.
  17. [19] ↑ . wikidata.org.
  18. [20] ↑ . wikidata.org.
  19. [21] ↑ . wikidata.org.
  20. [22] ↑ . wikidata.org.
  21. [23] ↑ . wikidata.org.
  22. [24] ↑ . wikidata.org.
  23. [25] ↑ . wikidata.org.
  24. [26] ↑ . wikidata.org.
  25. [27] ↑ . wikidata.org.
  26. [28] ↑ . wikidata.org.
  27. [29] ↑ . wikidata.org.
  28. [30] ↑ . wikidata.org.
  29. [31] ↑ . wikidata.org.
  30. [32] ↑ . wikidata.org.
  31. [33] ↑ . wikidata.org.
  32. [34] ↑ . wikidata.org.
  33. [35] ↑ . wikidata.org.
  34. [36] ↑ . wikidata.org.
  35. [37] ↑ . wikidata.org.
  36. [38] ↑ . wikidata.org.
  37. [39] ↑ . wikidata.org.
  38. [40] ↑ . wikidata.org.
  39. [41] ↑ . wikidata.org.
  40. [42] ↑ . wikidata.org.
  41. [43] ↑ . wikidata.org.
  42. [44] ↑ . wikidata.org.
  43. [45] ↑ . wikidata.org.
  44. [46] ↑ . wikidata.org.
  45. [47] ↑ . wikidata.org.
  46. [48] ↑ . wikidata.org.
  47. [49] ↑ . wikidata.org.
  48. [50] ↑ . wikidata.org.
  49. [51] ↑ . wikidata.org.
  50. [52] ↑ . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikimedia Foundation. dumps.wikimedia.org.
  2. [53] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Ectonucleotide pyrophosphatase/phosphodiesterase 1. Retrieved October 22, 2026, from https://4ort.xyz/entity/ectonucleotide-pyrophosphatase-phosphodiesterase-1
MLA “Ectonucleotide pyrophosphatase/phosphodiesterase 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 22 Oct. 2026, https://4ort.xyz/entity/ectonucleotide-pyrophosphatase-phosphodiesterase-1.
BibTeX @misc{4ortxyz_ectonucleotide-pyrophosphatase-phosphodiesterase-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Ectonucleotide pyrophosphatase/phosphodiesterase 1}}, year = {2026}, url = {https://4ort.xyz/entity/ectonucleotide-pyrophosphatase-phosphodiesterase-1}, note = {Accessed: 2026-10-22}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Ectonucleotide pyrophosphatase/phosphodiesterase 1 — https://4ort.xyz/entity/ectonucleotide-pyrophosphatase-phosphodiesterase-1 (retrieved 2026-10-22)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 7w ago · Giraffearaff · 2026-09-03 view diff on Wikidata ↗
    Substrate of → 2'-O,5'-O-((adenosine-3'-O,5'-O-diyl)bisphosphinico)guanosine
    "/* wbsetclaim-create:2||1 */ Substrate of: 2'-O,5'-O-((adenosine-3'-O,5'-O-diyl)bisphosphinico)guanosine"
  2. 13w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon → Homo sapiens
    Instance of → —
    Encoded by → ENPP1
    Cell component → integral component of membrane, membrane, plasma membrane +8
    + 9 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 3.1.4.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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