E2F transcription factor 7

mammalian protein found in Homo sapiens

Protein protein Q21105853

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Summary

E2F transcription factor 7 is a protein^[1].

Key Facts

E2F transcription factor 7's instance of is recorded as protein^[2].
E2F transcription factor 7's UniProt protein ID is recorded as Q96AV8^[3].
E2F transcription factor 7's part of is recorded as winged helix DNA-binding domain superfamily^[4].
E2F transcription factor 7's part of is recorded as Winged helix-like DNA-binding domain superfamily^[5].
E2F transcription factor 7's part of is recorded as E2F family^[6].
E2F transcription factor 7's part of is recorded as E2F/DP family, winged-helix DNA-binding domain, protein family^[7].
E2F transcription factor 7's MeSH descriptor ID is recorded as D050702^[8].
E2F transcription factor 7's has part is recorded as E2F/DP family, winged-helix DNA-binding domain^[9].
E2F transcription factor 7's RefSeq protein ID is recorded as NP_976328^[10].
E2F transcription factor 7's RefSeq protein ID is recorded as XP_011536268^[11].
E2F transcription factor 7's RefSeq protein ID is recorded as XP_011536271^[12].
E2F transcription factor 7's MeSH tree code is recorded as D12.776.930.211.968^[13].
E2F transcription factor 7's molecular function is recorded as DNA binding^[14].
E2F transcription factor 7's molecular function is recorded as RNA polymerase II transcription regulatory region sequence-specific DNA binding^[15].
E2F transcription factor 7's molecular function is recorded as transcription corepressor activity^[16].
E2F transcription factor 7's molecular function is recorded as protein binding^[17].
E2F transcription factor 7's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[18].
E2F transcription factor 7's molecular function is recorded as identical protein binding^[19].
E2F transcription factor 7's molecular function is recorded as DNA-binding transcription factor activity^[20].
E2F transcription factor 7's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[21].
E2F transcription factor 7's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[22].
E2F transcription factor 7's molecular function is recorded as cis-regulatory region sequence-specific DNA binding^[23].
E2F transcription factor 7's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[24].
E2F transcription factor 7's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[25].
E2F transcription factor 7's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[26].

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Quick Facts

Instance of protein

Part of winged helix DNA-binding domain superfamily, Winged helix-like DNA-binding domain superfamily, E2F family, E2F/DP family, winged-helix DNA-binding domain, protein family

Properties

Biological process trophoblast giant cell differentiation, regulation of transcription, DNA-templated, chorionic trophoblast cell differentiation, negative regulation of transcription involved in G1/S transition of mitotic cell cycle, placenta development, DNA damage response, signal transduction by p53 class mediator, hepatocyte differentiation, negative regulation of transcription by RNA polymerase II, transcription, DNA-templated, cellular response to DNA damage stimulus, negative regulation of G1/S transition of mitotic cell cycle, cell cycle, negative regulation of cytokinesis, positive regulation of DNA endoreduplication, positive regulation of transcription by RNA polymerase II, sprouting angiogenesis, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of cell cycle

Cell component transcription regulator complex, nucleus, nucleoplasm, nuclear speck, RNA polymerase II transcription regulator complex, nucleus

Encoded by E2F7

Found in taxon Homo sapiens

Has part(s) E2F/DP family, winged-helix DNA-binding domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, transcription corepressor activity, protein binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, identical protein binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, transcription factor binding, sequence-specific DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, DNA binding, DNA-binding transcription factor activity

External References (6)

Ensembl protein id ENSP00000323246, ENSP00000393639, ENSP00000447963, ENSP00000448245, ENSP00000449033, ENSP00000449284

Mesh descriptor id D050702

Mesh tree code D12.776.930.211.968

Refseq protein id NP_976328, XP_011536268, XP_011536271

Umls cui C1529677

Uniprot protein id Q96AV8

🏷️ Also known as

en E2F-7 en E2F7 en E2F transcription factor 7 en transcription factor E2F7

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ E2F transcription factor 7 — instance of (P31): protein. UniProt. Retrieved 2019-11-13. wikidata.org.
[3] ↑ E2F transcription factor 7 — UniProt protein ID (P352): Q96AV8. UniProt. Retrieved 2019-11-13. wikidata.org.
[4] ↑ E2F transcription factor 7 — part of (P361): winged helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ E2F transcription factor 7 — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ E2F transcription factor 7 — part of (P361): E2F family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ E2F transcription factor 7 — part of (P361): E2F/DP family, winged-helix DNA-binding domain, protein family. wikidata.org.
[8] ↑ E2F transcription factor 7 — MeSH descriptor ID (P486): D050702. wikidata.org.
[9] ↑ E2F transcription factor 7 — has part(s) (P527): E2F/DP family, winged-helix DNA-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ E2F transcription factor 7 — RefSeq protein ID (P637): NP_976328. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ E2F transcription factor 7 — RefSeq protein ID (P637): XP_011536268. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ E2F transcription factor 7 — RefSeq protein ID (P637): XP_011536271. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ E2F transcription factor 7 — MeSH tree code (P672): D12.776.930.211.968. wikidata.org.
[14] ↑ E2F transcription factor 7 — molecular function (P680): DNA binding. GOA. Retrieved 2018-11-07. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ E2F transcription factor 7 — molecular function (P680): RNA polymerase II transcription regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ E2F transcription factor 7 — molecular function (P680): transcription corepressor activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ E2F transcription factor 7 — molecular function (P680): protein binding. DNA-damage response control of E2F7 and E2F8. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ E2F transcription factor 7 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ E2F transcription factor 7 — molecular function (P680): identical protein binding. E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ E2F transcription factor 7 — molecular function (P680): DNA-binding transcription factor activity. E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. Retrieved 2018-11-07. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ E2F transcription factor 7 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. A census of human transcription factors: function, expression and evolution. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ E2F transcription factor 7 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ E2F transcription factor 7 — molecular function (P680): cis-regulatory region sequence-specific DNA binding. E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ E2F transcription factor 7 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. A census of human transcription factors: function, expression and evolution. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ E2F transcription factor 7 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ E2F transcription factor 7 — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ E2F transcription factor 7 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_e2f-transcription-factor-7-q21105853_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{E2F transcription factor 7}}, year = {2026}, url = {https://4ort.xyz/entity/e2f-transcription-factor-7-q21105853}, note = {Accessed: 2026-05-03}}

LLM prompt

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