E2F transcription factor 4

mammalian protein found in Homo sapiens

Protein protein Q21105842

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Summary

E2F transcription factor 4 is a protein^[1].

Key Facts

E2F transcription factor 4's instance of is recorded as protein^[2].
E2F transcription factor 4's UniProt protein ID is recorded as Province of Reggio Emilia^[3].
E2F transcription factor 4's part of is recorded as winged helix DNA-binding domain superfamily^[4].
E2F transcription factor 4's part of is recorded as Transcription factor E2F4^[5].
E2F transcription factor 4's part of is recorded as Winged helix-like DNA-binding domain superfamily^[6].
E2F transcription factor 4's part of is recorded as E2F-DP heterodimerization region^[7].
E2F transcription factor 4's part of is recorded as E2F/DP family, winged-helix DNA-binding domain, protein family^[8].
E2F transcription factor 4's part of is recorded as E2F transcription factor, CC-MB domain, protein family^[9].
E2F transcription factor 4's MeSH descriptor ID is recorded as D050704^[10].
E2F transcription factor 4's has part is recorded as E2F transcription factor, CC-MB domain^[11].
E2F transcription factor 4's has part is recorded as E2F/DP family, winged-helix DNA-binding domain^[12].
E2F transcription factor 4's RefSeq protein ID is recorded as NP_001941^[13].
E2F transcription factor 4's PDB structure ID is recorded as 1CF7^[14].
E2F transcription factor 4's MeSH tree code is recorded as D12.776.930.211.812^[15].
E2F transcription factor 4's molecular function is recorded as DNA binding^[16].
E2F transcription factor 4's molecular function is recorded as protein domain specific binding^[17].
E2F transcription factor 4's molecular function is recorded as DNA-binding transcription factor activity^[18].
E2F transcription factor 4's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[19].
E2F transcription factor 4's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[20].
E2F transcription factor 4's molecular function is recorded as transcription factor binding^[21].
E2F transcription factor 4's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[22].
E2F transcription factor 4's molecular function is recorded as protein binding^[23].
E2F transcription factor 4's molecular function is recorded as promoter-specific chromatin binding^[24].
E2F transcription factor 4's molecular function is recorded as protein dimerization activity^[25].
E2F transcription factor 4's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[26].

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Quick Facts

Instance of protein

Part of winged helix DNA-binding domain superfamily, Transcription factor E2F4, Winged helix-like DNA-binding domain superfamily, E2F-DP heterodimerization region, E2F/DP family, winged-helix DNA-binding domain, protein family, E2F transcription factor, CC-MB domain, protein family

Properties

Biological process regulation of cell size, epithelial cell development, cell volume homeostasis, regulation of transcription, DNA-templated, multi-ciliated epithelial cell differentiation, transcription by RNA polymerase II, regulation of transcription involved in G1/S transition of mitotic cell cycle, blood circulation, cell projection organization, regulation of cell population proliferation, animal organ morphogenesis, cell cycle, motile cilium assembly, centriole assembly, transcription, DNA-templated, mitotic cell cycle, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, positive regulation of transcription by RNA polymerase II, cilium assembly, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of cell cycle

Cell component transcription regulator complex, nucleoplasm, nucleus, RNA polymerase II transcription regulator complex, nucleus

Encoded by E2F4

Found in taxon Homo sapiens

Has part(s) E2F transcription factor, CC-MB domain, E2F/DP family, winged-helix DNA-binding domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, protein domain specific binding, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, promoter-specific chromatin binding, protein dimerization activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, transcription factor binding, sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific

External References (7)

Ensembl protein id ENSP00000368686, ENSP00000454477, ENSP00000457239, ENSP00000458082, ENSP00000458706

Mesh descriptor id D050704

Mesh tree code D12.776.930.211.812

Pdb structure id 1CF7

Refseq protein id NP_001941

Umls cui C0291135

Uniprot protein id Province of Reggio Emilia

🏷️ Also known as

en E2F4 en E2F transcription factor 4 en E2F transcription factor 4, p107/p130-binding en p107/p130-binding protein en transcription factor E2F4

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ E2F transcription factor 4 — instance of (P31): protein. UniProt. Retrieved 2019-11-13. wikidata.org.
[3] ↑ E2F transcription factor 4 — UniProt protein ID (P352): Province of Reggio Emilia. UniProt. Retrieved 2019-11-13. wikidata.org.
[4] ↑ E2F transcription factor 4 — part of (P361): winged helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ E2F transcription factor 4 — part of (P361): Transcription factor E2F4. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ E2F transcription factor 4 — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ E2F transcription factor 4 — part of (P361): E2F-DP heterodimerization region. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ E2F transcription factor 4 — part of (P361): E2F/DP family, winged-helix DNA-binding domain, protein family. wikidata.org.
[9] ↑ E2F transcription factor 4 — part of (P361): E2F transcription factor, CC-MB domain, protein family. wikidata.org.
[10] ↑ E2F transcription factor 4 — MeSH descriptor ID (P486): D050704. wikidata.org.
[11] ↑ E2F transcription factor 4 — has part(s) (P527): E2F transcription factor, CC-MB domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ E2F transcription factor 4 — has part(s) (P527): E2F/DP family, winged-helix DNA-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ E2F transcription factor 4 — RefSeq protein ID (P637): NP_001941. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ E2F transcription factor 4 — PDB structure ID (P638): 1CF7. UniProt. Retrieved 2016-08-09. wikidata.org.
[15] ↑ E2F transcription factor 4 — MeSH tree code (P672): D12.776.930.211.812. wikidata.org.
[16] ↑ E2F transcription factor 4 — molecular function (P680): DNA binding. E2F transcriptional activation requires TRRAP and GCN5 cofactors. Retrieved 2018-11-07. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ E2F transcription factor 4 — molecular function (P680): protein domain specific binding. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ E2F transcription factor 4 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2018-11-07. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ E2F transcription factor 4 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ E2F transcription factor 4 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ E2F transcription factor 4 — molecular function (P680): transcription factor binding. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ E2F transcription factor 4 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. In vivo structure of two divergent promoters at the human PCNA locus. Synthesis of antisense RNA and S phase-dependent binding of E2F complexes in intron 1. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ E2F transcription factor 4 — molecular function (P680): protein binding. E2F transcriptional activation requires TRRAP and GCN5 cofactors. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ E2F transcription factor 4 — molecular function (P680): promoter-specific chromatin binding. Post‐transcriptional gene expression control by NANOS is up‐regulated and functionally important in pR b‐deficient cells. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ E2F transcription factor 4 — molecular function (P680): protein dimerization activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ E2F transcription factor 4 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. A census of human transcription factors: function, expression and evolution. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ E2F transcription factor 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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BibTeX

@misc{4ortxyz_e2f-transcription-factor-4-q21105842_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{E2F transcription factor 4}}, year = {2026}, url = {https://4ort.xyz/entity/e2f-transcription-factor-4-q21105842}, note = {Accessed: 2026-05-03}}

LLM prompt

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