DOT1 like histone lysine methyltransferase

mammalian protein found in Homo sapiens
Protein protein Q21116404
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DOT1 like histone lysine methyltransferase

Summary

DOT1 like histone lysine methyltransferase is a protein[1].

Key Facts

  • DOT1 like histone lysine methyltransferase's instance of is recorded as protein[2].
  • DOT1 like histone lysine methyltransferase is part of Histone H3-K79 methyltransferase, metazoa[3].
  • DOT1 like histone lysine methyltransferase is part of S-adenosyl-L-methionine-dependent methyltransferase[4].
  • DOT1 like histone lysine methyltransferase is part of Histone-lysine N-methyltransferase DOT1 domain, protein family[5].
  • DOT1 like histone lysine methyltransferase comprises Histone-lysine N-methyltransferase DOT1 domain[6].
  • DOT1 like histone lysine methyltransferase's molecular function is recorded as methyltransferase activity[7].
  • DOT1 like histone lysine methyltransferase's molecular function is recorded as transferase activity[8].
  • DOT1 like histone lysine methyltransferase's molecular function is recorded as DNA binding[9].
  • DOT1 like histone lysine methyltransferase's molecular function is recorded as transcription factor binding[10].
  • DOT1 like histone lysine methyltransferase's molecular function is recorded as protein binding[11].
  • DOT1 like histone lysine methyltransferase's molecular function is recorded as histone methyltransferase activity[12].
  • DOT1 like histone lysine methyltransferase's molecular function is recorded as histone-lysine N-methyltransferase activity[13].
  • DOT1 like histone lysine methyltransferase's molecular function is recorded as histone methyltransferase activity (H3-K79 specific)[14].
  • DOT1 like histone lysine methyltransferase's molecular function is recorded as histone methyltransferase activity (H3-K79 specific)[15].
  • DOT1 like histone lysine methyltransferase's cell component is recorded as nucleoplasm[16].
  • DOT1 like histone lysine methyltransferase's cell component is recorded as nucleus[17].
  • DOT1 like histone lysine methyltransferase's cell component is recorded as telomere[18].
  • DOT1 like histone lysine methyltransferase's cell component is recorded as intracellular membrane-bounded organelle[19].
  • DOT1 like histone lysine methyltransferase's cell component is recorded as protein-containing complex[20].
  • DOT1 like histone lysine methyltransferase's cell component is recorded as nucleus[21].
  • DOT1 like histone lysine methyltransferase's biological process is recorded as telomere organization[22].
  • DOT1 like histone lysine methyltransferase's biological process is recorded as methylation[23].
  • DOT1 like histone lysine methyltransferase's biological process is recorded as regulation of transcription regulatory region DNA binding[24].
  • DOT1 like histone lysine methyltransferase's biological process is recorded as regulation of receptor signaling pathway via JAK-STAT[25].
  • DOT1 like histone lysine methyltransferase's biological process is recorded as positive regulation of transcription by RNA polymerase II[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] . Q905695. Retrieved . wikidata.org.
  2. [3] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] . wikidata.org.
  5. [6] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [8] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [9] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] . A Novel Disrupter of Telomere Silencing 1-like (DOT1L) Interaction Is Required for Signal Transducer and Activator of Transcription 1 (STAT1)-activated Gene Expression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] . A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] . hDOT1L links histone methylation to leukemogenesis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] . A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] . A Novel Disrupter of Telomere Silencing 1-like (DOT1L) Interaction Is Required for Signal Transducer and Activator of Transcription 1 (STAT1)-activated Gene Expression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] . A Novel Disrupter of Telomere Silencing 1-like (DOT1L) Interaction Is Required for Signal Transducer and Activator of Transcription 1 (STAT1)-activated Gene Expression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] . hDOT1L links histone methylation to leukemogenesis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). DOT1 like histone lysine methyltransferase. Retrieved May 3, 2026, from https://4ort.xyz/entity/dot1-like-histone-lysine-methyltransferase
MLA “DOT1 like histone lysine methyltransferase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/dot1-like-histone-lysine-methyltransferase.
BibTeX @misc{4ortxyz_dot1-like-histone-lysine-methyltransferase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{DOT1 like histone lysine methyltransferase}}, year = {2026}, url = {https://4ort.xyz/entity/dot1-like-histone-lysine-methyltransferase}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): DOT1 like histone lysine methyltransferase — https://4ort.xyz/entity/dot1-like-histone-lysine-methyltransferase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/dot1-like-histone-lysine-methyltransferase · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 5w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from
    Encoded by DOT1L
    Wikidata description mammalian protein found in Homo sapiens
    Molecular function methyltransferase activity, transferase activity, DNA binding +6
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.1.1.360, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.