Home › Entities › protein › DNA topoisomerase III alpha

DNA topoisomerase III alpha

mammalian protein found in Homo sapiens
Protein protein Q21121455
Press Enter · cited answer in seconds

Summary

DNA topoisomerase III alpha is a protein[1]. It is known by 6 alternative names across languages and contexts.[2]

Key Facts

  • Part of: DNA topoisomerase, type IA[3], DNA topoisomerase, type IA, central region, subdomain 2[4], DNA topoisomerase, type IA, core domain[5], DNA topoisomerase, type IA, central region, subdomain 1[6], DNA topoisomerase, type IA, central region, subdomain 3[7], DNA topoisomerase, type IA, DNA-binding domain, protein family[8], DNA topoisomerase, type IA, zn finger, protein family[9], Zinc finger, GRF-type, protein family[10], DNA topoisomerase 3-like, TOPRIM domain, protein family[11], DNA topoisomerase, type IA, domain 2, protein family[12], TOPRIM domain, protein family[13], DNA topoisomerase, type IA, central domain, protein family[14], DNA topoisomerase, type IA, active site, protein family[15]
  • Has part(s): DNA topoisomerase, type IA, central[16], Zinc finger, GRF-type[17], TOPRIM domain[18], DNA topoisomerase, type IA, zn finger[19], DNA topoisomerase, type IA, active site[20], DNA topoisomerase, type IA, domain 2[21], DNA topoisomerase, type IA, DNA-binding domain[22], DNA topoisomerase 3-like, TOPRIM domain[23]
  • Molecular function: DNA topoisomerase type I (single strand cut, ATP-independent) activity[24], DNA binding[25], zinc ion binding[26], protein binding[27], isomerase activity[28], metal ion binding[29], DNA topoisomerase activity[30], single-stranded DNA binding[31]
  • Cell component: PML body[32], nucleoplasm[33], chromosome[34], nucleus[35], mitochondrion[36], mitochondrial matrix[37]
  • Biological process: DNA replication[38], DNA topological change[39], meiosis[40], mitochondrial DNA metabolic process[41], chromosome separation[42], regulation of signal transduction by p53 class mediator[43]
  • Encoded by: TOP3A[44]
  • Found in taxon: Homo sapiens[45]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . wikidata.org.
  8. [10] ↑ . wikidata.org.
  9. [11] ↑ . wikidata.org.
  10. [12] ↑ . wikidata.org.
  11. [13] ↑ . wikidata.org.
  12. [14] ↑ . wikidata.org.
  13. [15] ↑ . wikidata.org.
  14. [16] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . Human TOP3: a single-copy gene encoding DNA topoisomerase III. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . Human TOP3: a single-copy gene encoding DNA topoisomerase III. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . Human TOP3: a single-copy gene encoding DNA topoisomerase III. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [41] ↑ . Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [42] ↑ . Mutations in TOP3A Cause a Bloom Syndrome-like Disorder. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [43] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  42. [44] ↑ . UniProt. Retrieved . wikidata.org.
  43. [45] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). DNA topoisomerase III alpha. Retrieved May 3, 2026, from https://4ort.xyz/entity/dna-topoisomerase-iii-alpha
MLA “DNA topoisomerase III alpha.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/dna-topoisomerase-iii-alpha.
BibTeX @misc{4ortxyz_dna-topoisomerase-iii-alpha_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{DNA topoisomerase III alpha}}, year = {2026}, url = {https://4ort.xyz/entity/dna-topoisomerase-iii-alpha}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): DNA topoisomerase III alpha — https://4ort.xyz/entity/dna-topoisomerase-iii-alpha (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/dna-topoisomerase-iii-alpha · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → TOP3A
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → DNA topoisomerase type I (single strand cut, ATP-independent) activity, DNA binding, zinc ion binding +6
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 5.6.2.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.