DNA topoisomerase I

mammalian protein found in Homo sapiens
Protein protein Q21130471
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DNA topoisomerase I

Summary

DNA topoisomerase I is a protein[1].

Key Facts

  • DNA topoisomerase I's instance of is recorded as protein[2].
  • DNA topoisomerase I's physically interacts with is recorded as 7-ethyl-10-hydroxycamptothecin[3].
  • DNA topoisomerase I's physically interacts with is recorded as ar-67[4].
  • DNA topoisomerase I's physically interacts with is recorded as edotecarin[5].
  • DNA topoisomerase I is part of DNA topoisomerase I, DNA binding, N-terminal domain 2[6].
  • DNA topoisomerase I is part of DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily[7].
  • DNA topoisomerase I is part of DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type[8].
  • DNA topoisomerase I is part of DNA topoisomerase I, subgroup[9].
  • DNA topoisomerase I is part of DNA topoisomerase I, catalytic core, alpha/beta subdomain[10].
  • DNA topoisomerase I is part of DNA breaking-rejoining enzyme, catalytic core[11].
  • DNA topoisomerase I is part of DNA topoisomerase I, DNA binding, N-terminal domain 1[12].
  • DNA topoisomerase I is part of DNA topoisomerase I domain, eukaryotic-type, protein family[13].
  • DNA topoisomerase I is part of DNA topoisomerase I, DNA binding, eukaryotic-type, protein family[14].
  • DNA topoisomerase I is part of Topoisomerase I C-terminal domain, protein family[15].
  • DNA topoisomerase I is part of DNA topoisomerase I, catalytic core, eukaryotic-type, protein family[16].
  • DNA topoisomerase I is part of DNA topoisomerase I, active site, protein family[17].
  • DNA topoisomerase I comprises DNA topoisomerase I, catalytic core, eukaryotic-type[18].
  • DNA topoisomerase I comprises DNA topoisomerase I, active site[19].
  • DNA topoisomerase I comprises Topoisomerase I C-terminal domain[20].
  • DNA topoisomerase I comprises DNA topoisomerase I domain, eukaryotic-type[21].
  • DNA topoisomerase I comprises DNA topoisomerase I, DNA binding, eukaryotic-type[22].
  • DNA topoisomerase I's molecular function is recorded as DNA topoisomerase type I (single strand cut, ATP-independent) activity[23].
  • DNA topoisomerase I's molecular function is recorded as chromatin binding[24].
  • DNA topoisomerase I's molecular function is recorded as isomerase activity[25].
  • DNA topoisomerase I's molecular function is recorded as DNA topoisomerase activity[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] . Q905695. Retrieved . wikidata.org.
  2. [3] . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  3. [4] . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  4. [5] . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  5. [6] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [8] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [9] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [10] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [11] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [12] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [13] . wikidata.org.
  13. [14] . wikidata.org.
  14. [15] . wikidata.org.
  15. [16] . wikidata.org.
  16. [17] . wikidata.org.
  17. [18] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  18. [19] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  19. [20] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  20. [21] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  21. [22] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  22. [23] . Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] . Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). DNA topoisomerase I. Retrieved May 3, 2026, from https://4ort.xyz/entity/dna-topoisomerase-i
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BibTeX @misc{4ortxyz_dna-topoisomerase-i_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{DNA topoisomerase I}}, year = {2026}, url = {https://4ort.xyz/entity/dna-topoisomerase-i}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 6d ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon Homo sapiens
    Physically interacts with 7-ethyl-10-hydroxycamptothecin, ar-67, edotecarin
    Wikidata description mammalian protein found in Homo sapiens
    Pdb structure id 1A31, 1A35, 1A36 +12
    + 14 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ [[Property:P591]]: 5.6.2.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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