DNA polymerase epsilon, catalytic subunit

mammalian protein found in Homo sapiens

Protein protein Q21117982

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Summary

DNA polymerase epsilon, catalytic subunit is a protein^[1].

Key Facts

DNA polymerase epsilon, catalytic subunit's instance of is recorded as protein^[2].
DNA polymerase epsilon, catalytic subunit is part of Ribonuclease H superfamily^[3].
DNA polymerase epsilon, catalytic subunit is part of Ribonuclease H-like superfamily^[4].
DNA polymerase epsilon, catalytic subunit is part of DNA polymerase epsilon catalytic subunit^[5].
DNA polymerase epsilon, catalytic subunit is part of DNA-directed DNA polymerase, family B, exonuclease domain, protein family^[6].
DNA polymerase epsilon, catalytic subunit is part of DNA polymerase epsilon, catalytic subunit A, C-terminal domain, protein family^[7].
DNA polymerase epsilon, catalytic subunit is part of DNA-directed DNA polymerase, family B, multifunctional domain, protein family^[8].
DNA polymerase epsilon, catalytic subunit comprises DNA-directed DNA polymerase, family B, exonuclease domain^[9].
DNA polymerase epsilon, catalytic subunit comprises DNA-directed DNA polymerase, family B, multifunctional domain^[10].
DNA polymerase epsilon, catalytic subunit comprises DNA polymerase epsilon, catalytic subunit A, C-terminal^[11].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as transferase activity^[12].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as nucleotide binding^[13].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as DNA binding^[14].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as 4 iron, 4 sulfur cluster binding^[15].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as nucleotidyltransferase activity^[16].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as iron-sulfur cluster binding^[17].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as zinc ion binding^[18].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as chromatin binding^[19].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as metal ion binding^[20].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as nucleic acid binding^[21].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as DNA-directed DNA polymerase activity^[22].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as single-stranded DNA 3'-5' exodeoxyribonuclease activity^[23].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as protein binding^[24].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as DNA binding^[25].
DNA polymerase epsilon, catalytic subunit's molecular function is recorded as DNA-directed DNA polymerase activity^[26].

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Quick Facts

Instance of protein

Part of Ribonuclease H superfamily, Ribonuclease H-like superfamily, DNA polymerase epsilon catalytic subunit, DNA-directed DNA polymerase, family B, exonuclease domain, protein family, DNA polymerase epsilon, catalytic subunit A, C-terminal domain, protein family, DNA-directed DNA polymerase, family B, multifunctional domain, protein family

Properties

Biological process nucleotide-excision repair, DNA gap filling, DNA synthesis involved in DNA repair, DNA biosynthetic process, embryonic organ development, nucleic acid phosphodiester bond hydrolysis, cellular response to DNA damage stimulus, base-excision repair, gap-filling, DNA repair, DNA replication, leading strand elongation, DNA replication proofreading, G1/S transition of mitotic cell cycle, mitotic cell cycle, base-excision repair, gap-filling, nucleotide-excision repair, DNA gap filling, DNA replication initiation, telomere maintenance via semi-conservative replication

Cell component plasma membrane, nucleoplasm, nucleus, epsilon DNA polymerase complex, epsilon DNA polymerase complex

Ec enzyme number 2.7.7.7

Encoded by POLE

Found in taxon Homo sapiens

Has part(s) DNA-directed DNA polymerase, family B, exonuclease domain, DNA-directed DNA polymerase, family B, multifunctional domain, DNA polymerase epsilon, catalytic subunit A, C-terminal

Molecular function transferase activity, nucleotide binding, DNA binding, 4 iron, 4 sulfur cluster binding, nucleotidyltransferase activity, iron-sulfur cluster binding, zinc ion binding, chromatin binding, metal ion binding, nucleic acid binding, DNA-directed DNA polymerase activity, single-stranded DNA 3'-5' exodeoxyribonuclease activity, protein binding, DNA binding, DNA-directed DNA polymerase activity

External References (3)

Ensembl protein id ENSP00000322570, ENSP00000442578, ENSP00000445753, ENSP00000479927, ENSP00000480727, ENSP00000500921, ENSP00000500233, ENSP00000500279

Refseq protein id NP_006222, XP_011533097, XP_011533099, XP_011533101, XP_011533104

Uniprot protein id Q07864

🏷️ Also known as

en 3'-5' exodeoxyribonuclease en DNA polymerase epsilon, catalytic subunit en DNA polymerase epsilon catalytic subunit A en DNA polymerase epsilon catalytic subunit protein en DNA polymerase II subunit A en POLE en polymerase (DNA directed), epsilon, catalytic subunit en polymerase (DNA) epsilon, catalytic subunit

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ DNA polymerase epsilon, catalytic subunit — instance of (P31): protein. UniProt. Retrieved 2019-11-13. wikidata.org.
[3] ↑ DNA polymerase epsilon, catalytic subunit — part of (P361): Ribonuclease H superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ DNA polymerase epsilon, catalytic subunit — part of (P361): Ribonuclease H-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ DNA polymerase epsilon, catalytic subunit — part of (P361): DNA polymerase epsilon catalytic subunit. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ DNA polymerase epsilon, catalytic subunit — part of (P361): DNA-directed DNA polymerase, family B, exonuclease domain, protein family. wikidata.org.
[7] ↑ DNA polymerase epsilon, catalytic subunit — part of (P361): DNA polymerase epsilon, catalytic subunit A, C-terminal domain, protein family. wikidata.org.
[8] ↑ DNA polymerase epsilon, catalytic subunit — part of (P361): DNA-directed DNA polymerase, family B, multifunctional domain, protein family. wikidata.org.
[9] ↑ DNA polymerase epsilon, catalytic subunit — has part(s) (P527): DNA-directed DNA polymerase, family B, exonuclease domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ DNA polymerase epsilon, catalytic subunit — has part(s) (P527): DNA-directed DNA polymerase, family B, multifunctional domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ DNA polymerase epsilon, catalytic subunit — has part(s) (P527): DNA polymerase epsilon, catalytic subunit A, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): transferase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): DNA binding. Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): 4 iron, 4 sulfur cluster binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): nucleotidyltransferase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): iron-sulfur cluster binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): zinc ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): chromatin binding. Distinctive activities of DNA polymerases during human DNA replication. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): metal ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): nucleic acid binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): DNA-directed DNA polymerase activity. Distinctive activities of DNA polymerases during human DNA replication. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): single-stranded DNA 3'-5' exodeoxyribonuclease activity. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): protein binding. Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): DNA binding. Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ DNA polymerase epsilon, catalytic subunit — molecular function (P680): DNA-directed DNA polymerase activity. Distinctive activities of DNA polymerases during human DNA replication. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ DNA polymerase epsilon, catalytic subunit is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). DNA polymerase epsilon, catalytic subunit. Retrieved May 3, 2026, from https://4ort.xyz/entity/dna-polymerase-epsilon-catalytic-subunit

MLA

“DNA polymerase epsilon, catalytic subunit.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/dna-polymerase-epsilon-catalytic-subunit.

BibTeX

@misc{4ortxyz_dna-polymerase-epsilon-catalytic-subunit_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{DNA polymerase epsilon, catalytic subunit}}, year = {2026}, url = {https://4ort.xyz/entity/dna-polymerase-epsilon-catalytic-subunit}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): DNA polymerase epsilon, catalytic subunit — https://4ort.xyz/entity/dna-polymerase-epsilon-catalytic-subunit (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/dna-polymerase-epsilon-catalytic-subunit · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

11w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → POLE

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → transferase activity, nucleotide binding, DNA binding +12

+ 10 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ Ec enzyme number: 2.7.7.7, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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