DNA ligase 4
mammalian protein found in Homo sapiens
Facts
9 properties- Instance of
- protein
- Part of
- BRCT domain superfamily, DNA ligase 4, DNA ligase, ATP-dependent, N-terminal domain superfamily, Nucleic acid-binding, OB-fold, DNA ligase, ATP-dependent, central domain, protein family, DNA ligase IV domain, protein family, DNA ligase, ATP-dependent, C-terminal domain, protein family, DNA ligase, ATP-dependent, N-terminal domain, protein family, BRCT domain, protein family, DNA ligase, ATP-dependent, conserved site, protein family[1][2][3][4][5][6][7][8][9][10]
- Biological process
- nucleotide-excision repair, DNA gap filling, double-strand break repair via classical nonhomologous end joining, response to ionizing radiation, DNA recombination, lagging strand elongation, DNA biosynthetic process, cellular response to lithium ion, single strand break repair, cellular response to DNA damage stimulus, cell division, DNA replication, positive regulation of chromosome organization, establishment of integrated proviral latency, cell cycle, response to X-ray, positive regulation of neurogenesis, DNA ligation involved in DNA recombination, DNA ligation, DNA ligation involved in DNA repair, somatic stem cell population maintenance, chromosome organization, T cell receptor V(D)J recombination, neuron apoptotic process, isotype switching, T cell differentiation in thymus, central nervous system development, immunoglobulin V(D)J recombination, double-strand break repair via nonhomologous end joining, positive regulation of fibroblast proliferation, in utero embryonic development, cell population proliferation, V(D)J recombination, pro-B cell differentiation, DNA repair, response to gamma radiation, double-strand break repair, negative regulation of neuron apoptotic process, nucleotide-excision repair, DNA gap filling, double-strand break repair via nonhomologous end joining, cellular response to ionizing radiation[35][36][37][38][39][40][41][42][43][44][45][46][47][48]
- Cell component
- nucleoplasm, DNA ligase IV complex, nonhomologous end joining complex, condensed chromosome, nucleus, DNA-dependent protein kinase-DNA ligase 4 complex, cytoplasm, cytoplasmic ribonucleoprotein granule, DNA-dependent protein kinase-DNA ligase 4 complex, DNA ligase IV complex[27][28][29][30][31][32][33][34]
- EC enzyme number
- 6.5.1.1[17]
- Encoded by
- LIG4
- Found in taxon
- Homo sapiens
🏷️ Also known as
en DNA joinase
en DNA ligase 4
en DNA ligase IV
en DNA repair enzyme
en LIG4
en ligase IV, DNA, ATP-dependent
en polydeoxyribonucleotide synthase [ATP] 4
en polynucleotide ligase
en sealase
🔖 Identifiers · 4
- Ensembl protein ID
- ENSP00000349393, ENSP00000385955, ENSP00000402030, ENSP00000484288, ENSP00000480814
- RefSeq protein ID
- NP_001091738, NP_001317524, NP_002303, NP_996820, NP_001339527, NP_001339528, NP_001339529, NP_001339530, NP_001339531, NP_001339532, NP_001339533, NP_001366024
- UniProt protein ID
- P49917
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