DNA ligase 1

mammalian protein found in Homo sapiens
Protein protein Q21117820
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Summary

DNA ligase 1 is a protein[1]. It is known by 5 alternative names across languages and contexts.[2]

Key Facts

  • Part of: Nucleic acid-binding, OB-fold[3], DNA ligase, ATP-dependent, N-terminal domain superfamily[4], DNA ligase, ATP-dependent[5], DNA ligase, ATP-dependent, central domain, protein family[6], DNA ligase, ATP-dependent, C-terminal domain, protein family[7], DNA ligase, ATP-dependent, N-terminal domain, protein family[8], DNA ligase, ATP-dependent, conserved site, protein family[9]
  • Has part(s): DNA ligase, ATP-dependent, N-terminal[10], DNA ligase, ATP-dependent, conserved site[11], DNA ligase, ATP-dependent, C-terminal[12], DNA ligase, ATP-dependent, central domain[13]
  • Molecular function: DNA binding[14], nucleotide binding[15], DNA ligase (ATP) activity[16], metal ion binding[17], ligase activity[18], ATP binding[19], DNA ligase activity[20]
  • Cell component: intracellular membrane-bounded organelle[21], nucleoplasm[22], mitochondrion[23], nucleus[24], cytoplasm[25]
  • Biological process: nucleotide-excision repair, DNA gap filling[26], DNA recombination[27], DNA biosynthetic process[28], anatomical structure morphogenesis[29], Okazaki fragment processing involved in mitotic DNA replication[30], cellular response to DNA damage stimulus[31], cell division[32], DNA replication[33], V(D)J recombination[34], DNA mismatch repair[35], DNA ligation involved in DNA repair[36], cell cycle[37], transcription-coupled nucleotide-excision repair[38], DNA repair[39]
  • Encoded by: LIG1[40]
  • Found in taxon: Homo sapiens[41]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . wikidata.org.
  8. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . UniProt. Retrieved . wikidata.org.
  39. [41] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). DNA ligase 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/dna-ligase-1-q21117820
MLA “DNA ligase 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/dna-ligase-1-q21117820.
BibTeX @misc{4ortxyz_dna-ligase-1-q21117820_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{DNA ligase 1}}, year = {2026}, url = {https://4ort.xyz/entity/dna-ligase-1-q21117820}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): DNA ligase 1 — https://4ort.xyz/entity/dna-ligase-1-q21117820 (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → LIG1
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → DNA binding, nucleotide binding, DNA ligase (ATP) activity +4
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 6.5.1.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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