DEAD-box helicase 3 X-linked

mammalian protein found in Homo sapiens

Protein protein Q21105627

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DEAD-box helicase 3 X-linked

Summary

DEAD-box helicase 3 X-linked is a protein^[1].

Key Facts

DEAD-box helicase 3 X-linked's instance of is recorded as protein^[2].
DEAD-box helicase 3 X-linked is part of P-loop containing nucleoside triphosphate hydrolase^[3].
DEAD-box helicase 3 X-linked is part of animal nuclear pore complex^[4].
DEAD-box helicase 3 X-linked is part of Helicase superfamily 1/2, ATP-binding domain, protein family^[5].
DEAD-box helicase 3 X-linked is part of Helicase, C-terminal domain, protein family^[6].
DEAD-box helicase 3 X-linked is part of DEAD/DEAH box helicase^[7].
DEAD-box helicase 3 X-linked is part of RNA helicase, DEAD-box type, Q motif, protein family^[8].
DEAD-box helicase 3 X-linked is part of ATP-dependent RNA helicase DEAD-box, conserved site, protein family^[9].
DEAD-box helicase 3 X-linked comprises RNA helicase, DEAD-box type, Q motif^[10].
DEAD-box helicase 3 X-linked comprises ATP-dependent RNA helicase DEAD-box, conserved site^[11].
DEAD-box helicase 3 X-linked comprises DEAD/DEAH box helicase domain^[12].
DEAD-box helicase 3 X-linked comprises Helicase superfamily 1/2, ATP-binding domain^[13].
DEAD-box helicase 3 X-linked comprises Helicase, C-terminal^[14].
DEAD-box helicase 3 X-linked's molecular function is recorded as DNA binding^[15].
DEAD-box helicase 3 X-linked's molecular function is recorded as nucleotide binding^[16].
DEAD-box helicase 3 X-linked's molecular function is recorded as nucleoside-triphosphatase activity^[17].
DEAD-box helicase 3 X-linked's molecular function is recorded as CTPase activity^[18].
DEAD-box helicase 3 X-linked's molecular function is recorded as helicase activity^[19].
DEAD-box helicase 3 X-linked's molecular function is recorded as poly(A) binding^[20].
DEAD-box helicase 3 X-linked's molecular function is recorded as ribosomal small subunit binding^[21].
DEAD-box helicase 3 X-linked's molecular function is recorded as RNA stem-loop binding^[22].
DEAD-box helicase 3 X-linked's molecular function is recorded as DNA helicase activity^[23].
DEAD-box helicase 3 X-linked's molecular function is recorded as transcription factor binding^[24].
DEAD-box helicase 3 X-linked's molecular function is recorded as ATPase activity^[25].
DEAD-box helicase 3 X-linked's molecular function is recorded as protein binding^[26].

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Quick Facts

Instance of protein

Part of P-loop containing nucleoside triphosphate hydrolase, animal nuclear pore complex, Helicase superfamily 1/2, ATP-binding domain, protein family, Helicase, C-terminal domain, protein family, DEAD/DEAH box helicase, RNA helicase, DEAD-box type, Q motif, protein family, ATP-dependent RNA helicase DEAD-box, conserved site, protein family

Properties

Biological process stress granule assembly, apoptotic process, negative regulation of translation, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, intracellular signal transduction, regulation of transcription, DNA-templated, ribosome biogenesis, negative regulation of intrinsic apoptotic signaling pathway, immune system process, chromosome segregation, negative regulation of protein-containing complex assembly, response to virus, negative regulation of apoptotic process, Wnt signaling pathway, positive regulation of translation, protein localization to cytoplasmic stress granule, transcription, DNA-templated, cellular response to osmotic stress, positive regulation of G1/S transition of mitotic cell cycle, intrinsic apoptotic signaling pathway, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of cell growth, positive regulation of gene expression, mature ribosome assembly, cellular response to arsenic-containing substance, negative regulation of cell growth, positive regulation of chemokine (C-C motif) ligand 5 production, RNA secondary structure unwinding, positive regulation of apoptotic process, positive regulation of viral genome replication, viral process, innate immune response, positive regulation of translational initiation, regulation of translation, extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of transcription by RNA polymerase II, positive regulation of interferon-beta production, DNA duplex unwinding, neutrophil degranulation, positive regulation of protein serine/threonine kinase activity, positive regulation of canonical Wnt signaling pathway, translational initiation

Cell component cytoplasm, eukaryotic translation initiation factor 3 complex, nuclear speck, membrane, mitochondrial outer membrane, cytosolic small ribosomal subunit, mitochondrion, cytoplasmic stress granule, extracellular exosome, nucleus, extracellular region, cytosol, secretory granule lumen, ficolin-1-rich granule lumen, nucleolus, extracellular exosome

Ec enzyme number 3.6.4.13

Encoded by DDX3X

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) RNA helicase, DEAD-box type, Q motif, ATP-dependent RNA helicase DEAD-box, conserved site, DEAD/DEAH box helicase domain, Helicase superfamily 1/2, ATP-binding domain, Helicase, C-terminal

Molecular function DNA binding, nucleotide binding, nucleoside-triphosphatase activity, CTPase activity, helicase activity, poly(A) binding, ribosomal small subunit binding, RNA stem-loop binding, DNA helicase activity, transcription factor binding, ATPase activity, protein binding, GTPase activity, eukaryotic initiation factor 4E binding, RNA binding, nucleic acid binding, mRNA 5'-UTR binding, translation initiation factor binding, hydrolase activity, ATP binding, RNA strand annealing activity, cadherin binding, protein serine/threonine kinase activator activity, RNA binding, cadherin binding

External References (5)

Ensembl protein id ENSP00000382840, ENSP00000392494, ENSP00000478443, ENSP00000486516, ENSP00000486720, ENSP00000487224, ENSP00000414281, ENSP00000479790, ENSP00000480647, ENSP00000486306, ENSP00000486443, ENSP00000486514, ENSP00000487062, ENSP00000487626, ENSP00000494767, ENSP00000496356, ENSP00000493819, ENSP00000496076, ENSP00000495264, ENSP00000496524, ENSP00000496222, ENSP00000494518, ENSP00000496043, ENSP00000494588, ENSP00000496663, ENSP00000495377, ENSP00000494952, ENSP00000493997, ENSP00000494905, ENSP00000496052, ENSP00000493976, ENSP00000493795, ENSP00000494887, ENSP00000493687, ENSP00000494040, ENSP00000493475, ENSP00000496257

Pdb structure id 2I4I, 2JGN, 3JRV, 4O2C, 4O2E, 4O2F, 4PX9, 4PXA, 5E7J, 5E7M, 5E7I

Refseq protein id NP_001180345, NP_001180346, NP_001347, XP_011542194, XP_016884802, NP_001350748

Transporter classification database id 1.I.1.1.3

Uniprot protein id O00571

🏷️ Also known as

en ATP-dependent RNA helicase DDX3X en DDX3X en DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked en DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked en DEAD-box helicase 3 X-linked en DEAD box protein 3, X-chromosomal en DEAD box, X isoform en DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 en DEAD/H box-3 en helicase-like protein 2 en HLP2

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ DEAD-box helicase 3 X-linked — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ DEAD-box helicase 3 X-linked — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ DEAD-box helicase 3 X-linked — part of (P361): animal nuclear pore complex. Retrieved 2019-10-02. wikidata.org.
[5] ↑ DEAD-box helicase 3 X-linked — part of (P361): Helicase superfamily 1/2, ATP-binding domain, protein family. wikidata.org.
[6] ↑ DEAD-box helicase 3 X-linked — part of (P361): Helicase, C-terminal domain, protein family. wikidata.org.
[7] ↑ DEAD-box helicase 3 X-linked — part of (P361): DEAD/DEAH box helicase. wikidata.org.
[8] ↑ DEAD-box helicase 3 X-linked — part of (P361): RNA helicase, DEAD-box type, Q motif, protein family. wikidata.org.
[9] ↑ DEAD-box helicase 3 X-linked — part of (P361): ATP-dependent RNA helicase DEAD-box, conserved site, protein family. wikidata.org.
[10] ↑ DEAD-box helicase 3 X-linked — has part(s) (P527): RNA helicase, DEAD-box type, Q motif. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ DEAD-box helicase 3 X-linked — has part(s) (P527): ATP-dependent RNA helicase DEAD-box, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ DEAD-box helicase 3 X-linked — has part(s) (P527): DEAD/DEAH box helicase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ DEAD-box helicase 3 X-linked — has part(s) (P527): Helicase superfamily 1/2, ATP-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ DEAD-box helicase 3 X-linked — has part(s) (P527): Helicase, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): nucleoside-triphosphatase activity. Hepatitis C virus core protein interacts with cellular putative RNA helicase. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): CTPase activity. Hepatitis C virus core protein interacts with cellular putative RNA helicase. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): helicase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): poly(A) binding. The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): ribosomal small subunit binding. The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): RNA stem-loop binding. DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): DNA helicase activity. A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): transcription factor binding. DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): ATPase activity. A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ DEAD-box helicase 3 X-linked — molecular function (P680): protein binding. RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ DEAD-box helicase 3 X-linked is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). DEAD-box helicase 3 X-linked. Retrieved May 3, 2026, from https://4ort.xyz/entity/dead-box-helicase-3-x-linked

MLA

“DEAD-box helicase 3 X-linked.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/dead-box-helicase-3-x-linked.

BibTeX

@misc{4ortxyz_dead-box-helicase-3-x-linked_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{DEAD-box helicase 3 X-linked}}, year = {2026}, url = {https://4ort.xyz/entity/dead-box-helicase-3-x-linked}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): DEAD-box helicase 3 X-linked — https://4ort.xyz/entity/dead-box-helicase-3-x-linked (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/dead-box-helicase-3-x-linked · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

5w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → DDX3X

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → DNA binding, nucleotide binding, nucleoside-triphosphatase activity +22

+ 13 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 3.6.4.13, [[:toollabs:quickstatements/#/batch/261489|batch #261489]]"

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