Cyclin dependent kinase inhibitor 1B

mammalian protein found in Homo sapiens

Protein protein Q5009962

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Cyclin dependent kinase inhibitor 1B

Summary

Cyclin dependent kinase inhibitor 1B is a protein^[1].

Key Facts

Cyclin dependent kinase inhibitor 1B's instance of is recorded as protein^[2].
Cyclin dependent kinase inhibitor 1B's UniProt protein ID is recorded as P46527^[3].
Cyclin dependent kinase inhibitor 1B's part of is recorded as cyclin-dependent kinase inhibitor 1B^[4].
Cyclin dependent kinase inhibitor 1B's RefSeq protein ID is recorded as NP_004055^[5].
Cyclin dependent kinase inhibitor 1B's PDB structure ID is recorded as 2AST^[6].
Cyclin dependent kinase inhibitor 1B's PDB structure ID is recorded as 1H27^[7].
Cyclin dependent kinase inhibitor 1B's PDB structure ID is recorded as 1JSU^[8].
Cyclin dependent kinase inhibitor 1B's Freebase ID is recorded as /m/03c9fzz^[9].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as protein binding^[10].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as protein phosphatase binding^[11].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as cyclin-dependent protein serine/threonine kinase activity^[12].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as protein kinase inhibitor activity^[13].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as protein kinase binding^[14].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as cyclin binding^[15].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as cyclin-dependent protein serine/threonine kinase inhibitor activity^[16].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as Hsp70 protein binding^[17].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as protein-containing complex binding^[18].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as chaperone binding^[19].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as cyclin-dependent protein serine/threonine kinase inhibitor activity^[20].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as protein kinase binding^[21].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as protein phosphatase binding^[22].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as Hsp70 protein binding^[23].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as protein-containing complex binding^[24].
Cyclin dependent kinase inhibitor 1B's molecular function is recorded as chaperone binding^[25].
Cyclin dependent kinase inhibitor 1B's cell component is recorded as cytoplasm^[26].

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Quick Facts

Instance of protein

Part of cyclin-dependent kinase inhibitor 1B

Properties

Biological process Notch signaling pathway, regulation of cyclin-dependent protein serine/threonine kinase activity, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, response to estradiol, positive regulation of cell death, response to hypoxia, response to amino acid, response to cadmium ion, positive regulation of protein catabolic process, response to organic cyclic compound, cellular response to lithium ion, cellular response to organic cyclic compound, response to peptide hormone, cell death, negative regulation of apoptotic process, hearing, response to glucose, potassium ion transport, regulation of cell population proliferation, negative regulation of cell growth, negative regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of cell population proliferation, positive regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of epithelial cell proliferation, positive regulation of microtubule polymerization, inner ear development, cellular response to antibiotic, cell cycle, negative regulation of phosphorylation, negative regulation of transcription, DNA-templated, autophagic cell death, negative regulation of cell population proliferation, negative regulation of mitotic cell cycle, negative regulation of kinase activity, positive regulation of cell cycle, negative regulation of vascular associated smooth muscle cell proliferation, placenta development, regulation of exit from mitosis, regulation of lens fiber cell differentiation, negative regulation of cyclin-dependent protein kinase activity, negative regulation of cell cycle, negative regulation of cyclin-dependent protein serine/threonine kinase activity, G1/S transition of mitotic cell cycle, G1/S transition of mitotic cell cycle, response to hypoxia, potassium ion transport, regulation of exit from mitosis, Notch signaling pathway, hearing, positive regulation of cell population proliferation, negative regulation of cell population proliferation, response to glucose, negative regulation of cell growth, positive regulation of microtubule polymerization, response to estradiol, negative regulation of phosphorylation, response to amino acid, response to peptide hormone, positive regulation of protein catabolic process, negative regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of transcription, DNA-templated, response to cadmium ion, autophagic cell death, cellular response to organic cyclic compound, regulation of lens fiber cell differentiation

Cell component cytoplasm, cytosol, endosome, nucleoplasm, Cul4A-RING E3 ubiquitin ligase complex, nucleus, intracellular membrane-bounded organelle, protein-containing complex, nucleus, cytoplasm, cytosol, Cul4A-RING E3 ubiquitin ligase complex, protein-containing complex

Encoded by CDKN1B

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Imported from wholeness_audit_2026-05-02

Molecular function protein binding, protein phosphatase binding, cyclin-dependent protein serine/threonine kinase activity, protein kinase inhibitor activity, protein kinase binding, cyclin binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, Hsp70 protein binding, protein-containing complex binding, chaperone binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein kinase binding, protein phosphatase binding, Hsp70 protein binding, protein-containing complex binding, chaperone binding

External References (5)

Ensembl protein id ENSP00000228872, ENSP00000379629, ENSP00000407597

Freebase id /m/03c9fzz

Pdb structure id 2AST, 1H27, 1JSU

Refseq protein id NP_004055

Uniprot protein id P46527

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Cyclin dependent kinase inhibitor 1B — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Cyclin dependent kinase inhibitor 1B — UniProt protein ID (P352): P46527. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Cyclin dependent kinase inhibitor 1B — part of (P361): cyclin-dependent kinase inhibitor 1B. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Cyclin dependent kinase inhibitor 1B — RefSeq protein ID (P637): NP_004055. Q20641742. Retrieved 2020-05-30. wikidata.org.
[6] ↑ Cyclin dependent kinase inhibitor 1B — PDB structure ID (P638): 2AST. Q905695. Retrieved 2016-08-09. wikidata.org.
[7] ↑ Cyclin dependent kinase inhibitor 1B — PDB structure ID (P638): 1H27. Q905695. Retrieved 2016-08-09. wikidata.org.
[8] ↑ Cyclin dependent kinase inhibitor 1B — PDB structure ID (P638): 1JSU. Q905695. Retrieved 2016-08-09. wikidata.org.
[9] ↑ Cyclin dependent kinase inhibitor 1B — Freebase ID (P646): /m/03c9fzz. Freebase Data Dumps. wikidata.org.
[10] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): protein binding. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): protein phosphatase binding. Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): cyclin-dependent protein serine/threonine kinase activity. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): protein kinase inhibitor activity. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): protein kinase binding. p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): cyclin binding. p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): cyclin-dependent protein serine/threonine kinase inhibitor activity. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): Hsp70 protein binding. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): protein-containing complex binding. p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): chaperone binding. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): cyclin-dependent protein serine/threonine kinase inhibitor activity. GOA. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): protein kinase binding. p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): protein phosphatase binding. Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): Hsp70 protein binding. GOA. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): protein-containing complex binding. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Cyclin dependent kinase inhibitor 1B — molecular function (P680): chaperone binding. GOA. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Cyclin dependent kinase inhibitor 1B — cell component (P681): cytoplasm. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Cyclin dependent kinase inhibitor 1B is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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