cyclin dependent kinase 5

mammalian protein found in Homo sapiens

Protein protein Q21116933

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Summary

cyclin dependent kinase 5 is a protein^[1]. It is known by 12 alternative names across languages and contexts.^[2]

Key Facts

cyclin dependent kinase 5's instance of is recorded as protein^[3].
cyclin dependent kinase 5's physically interacts with is recorded as dinaciclib^[4].
cyclin dependent kinase 5's physically interacts with is recorded as dinaciclib^[5].
cyclin dependent kinase 5's physically interacts with is recorded as at-7519^[6].
cyclin dependent kinase 5's physically interacts with is recorded as AZD5438^[7].
cyclin dependent kinase 5's physically interacts with is recorded as rgb-286638 free base^[8].
cyclin dependent kinase 5 is part of Protein kinase-like domain superfamily^[9].
cyclin dependent kinase 5 is part of Protein kinase domain, protein family^[10].
cyclin dependent kinase 5 is part of Protein kinase, ATP binding site, protein family^[11].
cyclin dependent kinase 5 is part of Serine/threonine-protein kinase, active site, protein family^[12].
cyclin dependent kinase 5 comprises serine/threonine-protein kinase, active site^[13].
cyclin dependent kinase 5 comprises protein kinase, ATP binding site^[14].
cyclin dependent kinase 5 comprises protein kinase domain^[15].
cyclin dependent kinase 5's molecular function is recorded as acetylcholine receptor activator activity^[16].
cyclin dependent kinase 5's molecular function is recorded as kinase activity^[17].
cyclin dependent kinase 5's molecular function is recorded as cytoskeletal protein binding^[18].
cyclin dependent kinase 5's molecular function is recorded as ATP binding^[19].
cyclin dependent kinase 5's molecular function is recorded as protein kinase activity^[20].
cyclin dependent kinase 5's molecular function is recorded as protein serine/threonine kinase activity^[21].
cyclin dependent kinase 5's molecular function is recorded as ErbB-3 class receptor binding^[22].
cyclin dependent kinase 5's molecular function is recorded as transferase activity^[23].
cyclin dependent kinase 5's molecular function is recorded as ephrin receptor binding^[24].
cyclin dependent kinase 5's molecular function is recorded as tau-protein kinase activity^[25].
cyclin dependent kinase 5's molecular function is recorded as protein binding^[26].
cyclin dependent kinase 5's molecular function is recorded as protein kinase binding^[27].

Why It Matters

cyclin dependent kinase 5 is known by 12 alternative names across languages and contexts.^[2]

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Quick Facts

Instance of protein

Part of Protein kinase-like domain superfamily, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process synaptic transmission, glutamatergic, rhythmic process, negative regulation of cell cycle, oligodendrocyte differentiation, synaptic transmission, dopaminergic, protein phosphorylation, positive regulation of neuron apoptotic process, central nervous system neuron development, regulation of synaptic vesicle recycling, cell cycle, regulated exocytosis, corpus callosum development, cell population proliferation, intracellular protein transport, neuron projection development, regulation of dendritic spine morphogenesis, negative regulation of synaptic plasticity, cerebellar cortex formation, exocytosis, response to cocaine, apoptotic process, regulation of apoptotic process, negative regulation of proteolysis, behavioral response to cocaine, synaptic vesicle exocytosis, receptor clustering, positive regulation of calcium ion-dependent exocytosis, telencephalon development, synaptic vesicle endocytosis, response to wounding, regulation of postsynaptic membrane potential, excitatory postsynaptic potential, synapse assembly, protein autophosphorylation, positive regulation of actin cytoskeleton reorganization, negative regulation of neuron death, chemical synaptic transmission, neuron apoptotic process, neuron projection morphogenesis, associative learning, dendrite morphogenesis, phosphorylation, calcium ion import, Schwann cell development, neuron migration, cerebellum development, nervous system development, regulation of synaptic plasticity, neuron differentiation, cerebral cortex development, axon extension, sensory perception of pain, positive regulation of protein binding, cell-matrix adhesion, peptidyl-threonine phosphorylation, negative regulation of transcription, DNA-templated, negative regulation of axon extension, cortical actin cytoskeleton organization, protein localization to synapse, positive regulation of protein targeting to membrane, positive regulation of protein kinase activity, visual learning, regulation of cell migration, axonogenesis, positive regulation of neuron death, receptor catabolic process, cell division, negative regulation of protein ubiquitination, positive regulation of signaling receptor activity, negative regulation of protein export from nucleus, layer formation in cerebral cortex, peptidyl-serine phosphorylation, nucleocytoplasmic transport, cerebellar cortex development, forebrain development, motor neuron axon guidance, cell migration, skeletal muscle tissue development, hippocampus development, regulation of macroautophagy, regulation of signal transduction by p53 class mediator, serine phosphorylation of STAT protein, microtubule cytoskeleton organization, positive regulation of protein phosphorylation, protein phosphorylation, mitochondrion organization, axonogenesis, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, neuron projection development, positive regulation of glial cell apoptotic process, synaptic vesicle transport, neuron apoptotic process, regulation of synaptic transmission, glutamatergic, synapse pruning, positive regulation of presynaptic cytosolic calcium concentration, induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration, regulation of protein localization to plasma membrane, cellular response to amyloid-beta

Cell component postsynaptic membrane, membrane, synapse, cytoskeleton, cell projection, lamellipodium, perikaryon, filopodium, growth cone, neuromuscular junction, plasma membrane, axon, soma, postsynaptic density, cell junction, dendrite, protein kinase 5 complex, presynapse, nucleoplasm, nucleus, cytoplasm, cytosol, cytoplasm, microtubule, neuron projection, Schaffer collateral - CA1 synapse, postsynapse, glutamatergic synapse

Ec enzyme number 2.7.11.1

Encoded by CDK5

Found in taxon Homo sapiens

Has part(s) serine/threonine-protein kinase, active site, protein kinase, ATP binding site, protein kinase domain

Molecular function acetylcholine receptor activator activity, kinase activity, cytoskeletal protein binding, ATP binding, protein kinase activity, protein serine/threonine kinase activity, ErbB-3 class receptor binding, transferase activity, ephrin receptor binding, tau-protein kinase activity, protein binding, protein kinase binding, nucleotide binding, p53 binding, ErbB-2 class receptor binding, cyclin-dependent protein serine/threonine kinase activity, protein serine/threonine kinase activity, microtubule binding, tau protein binding, tau-protein kinase activity, Hsp90 protein binding, voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels

Physically interacts with dinaciclib, dinaciclib, at-7519, AZD5438, rgb-286638 free base

External References (8)

Ensembl protein id ENSP00000297518, ENSP00000419782

Mesh descriptor id D051360

Mesh tree code D08.811.913.696.620.682.700.646.500.500.500, D12.776.167.200.067.875, D12.776.476.563.646.500.500.500

Pdb structure id 1H4L, 1UNG, 1UNH, 1UNL, 3O0G, 4AU8

Refseq protein id NP_001157882, NP_004926

Transporter classification database id 1.I.1.1.3

Umls cui C0249586

Uniprot protein id Q00535

🏷️ Also known as

en TPKII catalytic subunit en CDK5 en cell division protein kinase 5 en cyclin dependent kinase 5 en Cyclin-Dependent Kinase 5 en cyclin-dependent-like kinase 5 en epididymis secretory sperm binding protein en protein kinase CDK5 splicing en serine/threonine-protein kinase PSSALRE en tau protein kinase II catalytic subunit de Cyclinabhängige Kinase 5 hu ciklindependens kináz 5

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). cyclin dependent kinase 5. Retrieved May 3, 2026, from https://4ort.xyz/entity/cyclin-dependent-kinase-5-q21116933

MLA

“cyclin dependent kinase 5.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/cyclin-dependent-kinase-5-q21116933.

BibTeX

@misc{4ortxyz_cyclin-dependent-kinase-5-q21116933_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{cyclin dependent kinase 5}}, year = {2026}, url = {https://4ort.xyz/entity/cyclin-dependent-kinase-5-q21116933}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): cyclin dependent kinase 5 — https://4ort.xyz/entity/cyclin-dependent-kinase-5-q21116933 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/cyclin-dependent-kinase-5-q21116933 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

12w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Found in taxon → Homo sapiens

Physically interacts with → dinaciclib, dinaciclib, at-7519 +2

Wikidata description → mammalian protein found in Homo sapiens

Mesh tree code → D08.811.913.696.620.682.700.646.500.500.500, D12.776.167.200.067.875, D12.776.476.563.646.500.500.500

+ 16 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ Ec enzyme number: 2.7.11.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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