Cyclin-dependent kinase 5
mammalian protein found in Mus musculus
Facts
8 properties- Instance of
- protein
- Part of
- Protein kinase-like domain superfamily, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family[2][3][4][5]
- Biological process
- negative regulation of cell cycle, response to cocaine, negative regulation of axon extension, axonogenesis, cerebellar cortex formation, intracellular protein transport, layer formation in cerebral cortex, regulation of cell migration, Schwann cell development, associative learning, receptor catabolic process, calcium ion import, phosphorylation, positive regulation of protein binding, central nervous system neuron development, cerebral cortex development, neuron migration, cell-matrix adhesion, positive regulation of protein targeting to membrane, corpus callosum development, nervous system development, peptidyl-threonine phosphorylation, hippocampus development, protein phosphorylation, excitatory postsynaptic potential, synaptic transmission, dopaminergic, synaptic transmission, glutamatergic, forebrain development, cell cycle, receptor clustering, negative regulation of protein ubiquitination, apoptotic process, negative regulation of transcription, DNA-templated, cell division, positive regulation of calcium ion-dependent exocytosis, negative regulation of protein export from nucleus, negative regulation of synaptic plasticity, rhythmic process, regulation of postsynaptic membrane potential, telencephalon development, negative regulation of proteolysis, motor neuron axon guidance, cerebellar cortex development, protein localization to synapse, positive regulation of protein kinase activity, sensory perception of pain, skeletal muscle tissue development, dendrite morphogenesis, synapse assembly, negative regulation of neuron death, peptidyl-serine phosphorylation, cell migration, regulation of dendritic spine morphogenesis, cerebellum development, oligodendrocyte differentiation, visual learning, behavioral response to cocaine, neuron projection development, protein autophosphorylation, positive regulation of signaling receptor activity, neuron apoptotic process, cortical actin cytoskeleton organization, nucleocytoplasmic transport, regulation of synaptic plasticity, response to wounding, positive regulation of neuron death, neuron differentiation, positive regulation of neuron apoptotic process, synaptic vesicle endocytosis, regulated exocytosis, neuron projection morphogenesis, exocytosis, synaptic vesicle transport, serine phosphorylation of STAT protein, cellular response to amyloid-beta, positive regulation of protein phosphorylation, protein phosphorylation, exocytosis, nucleocytoplasmic transport, mitochondrion organization, axonogenesis, response to wounding, peptidyl-threonine phosphorylation, neuron differentiation, cortical actin cytoskeleton organization, neuron projection development, positive regulation of glial cell apoptotic process, positive regulation of neuron apoptotic process, regulated exocytosis, protein autophosphorylation, regulation of synaptic plasticity, synaptic vesicle endocytosis, neuron projection morphogenesis, neuron apoptotic process, regulation of synaptic transmission, glutamatergic, synapse pruning, positive regulation of presynaptic cytosolic calcium concentration, induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration, positive regulation of neuron death, regulation of protein localization to plasma membrane, cellular response to amyloid-beta, regulation of neurotransmitter receptor activity
- Cell component
- nucleus, synapse, perikaryon, plasma membrane, lamellipodium, cell projection, postsynaptic membrane, nucleolus, cell junction, filopodium, axon, cytoskeleton, growth cone, postsynaptic density, soma, membrane, dendrite, neuromuscular junction, protein kinase 5 complex, nucleoplasm, cytoplasm, cytosol, nucleus, cytoplasm, cytosol, cytoskeleton, microtubule, postsynaptic density, membrane, protein kinase 5 complex, axon, dendrite, growth cone, neuromuscular junction, neuron projection, soma, Schaffer collateral - CA1 synapse, presynapse, postsynapse, glutamatergic synapse
- Encoded by
- Cdk5
- Found in taxon
- house mouse
- Has part(s)
- protein kinase domain, protein kinase, ATP binding site, serine/threonine-protein kinase, active site[6][7][8]
- Molecular function
- p53 binding, ErbB-3 class receptor binding, transferase activity, protein kinase activity, nucleotide binding, acetylcholine receptor activator activity, ATP binding, protein binding, ErbB-2 class receptor binding, tau-protein kinase activity, kinase activity, ephrin receptor binding, protein kinase binding, cytoskeletal protein binding, protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase activity, cytoskeletal protein binding, kinase activity, protein kinase binding, ephrin receptor binding, tau-protein kinase activity, Hsp90 protein binding, voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels[9][10][11][12][13][14][15][16][17][18][19][20][21][22]
🏷️ Also known as
en TPKII catalytic subunit
en Cdk5
en cell division protein kinase 5
en CR6 protein kinase
en CRK6
en Cyclin-dependent kinase 5
en cyclin-dependent-like kinase 5
en serine/threonine-protein kinase PSSALRE
en tau protein kinase II catalytic subunit
de Cyclinabhängige Kinase 5
hu ciklindependens kináz 5
🔖 Identifiers · 3
- Ensembl protein ID
- ENSMUSP00000030814, ENSMUSP00000142413
- RefSeq protein ID
- NP_031694, XP_006535689
- UniProt protein ID
- P49615
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Summary
Cyclin-dependent kinase 5 is a protein[1].