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Complement C2

mammalian protein found in Homo sapiens
Protein Protein Q21102425

Facts

10 properties
Instance of
protein
Part of
von Willebrand factor A-like domain superfamily, Peptidase S1, PA clan, complement C2, Sushi/SCR/CCP superfamily, Sushi/SCR/CCP domain, protein family, von Willebrand factor, type A, protein family, Serine proteases, trypsin domain, protein family, Serine proteases, trypsin family, histidine active site, protein family, Serine proteases, trypsin family, serine active site, protein family[1][2][3][4][5][6][7][8][9]
Biological process
complement activation, positive regulation of apoptotic cell clearance, regulation of complement activation, response to nutrient, proteolysis, complement activation, classical pathway, immune system process, innate immune response[25][26][27][28][29][30][31][32]
Cell component
extracellular region, extracellular exosome, extracellular space, extracellular space, extracellular exosome[22][23][24]
Different from
C2
EC enzyme number
3.4.21.43[15]
Encoded by
C2[33]
Found in taxon
Homo sapiens[34]
Has part(s)
serine proteases, trypsin domain, sushi/SCR/CCP domain, serine proteases, trypsin family, histidine active site, Serine proteases, trypsin family, serine active site, von Willebrand factor, type A[10][11][12][13][14]
Molecular function
peptidase activity, serine-type peptidase activity, hydrolase activity, metal ion binding, serine-type endopeptidase activity, protein binding, serine-type endopeptidase activity[16][17][18][19][20][21]
🏷️ Also known as
en C2 en C3/C5 convertase en Complement C2 en complement component 2 en complement component C2
🔖 Identifiers · 4
Ensembl protein ID
ENSP00000299367, ENSP00000364660, ENSP00000372853, ENSP00000392322, ENSP00000392835, ENSP00000395683, ENSP00000402278, ENSP00000405800, ENSP00000407961, ENSP00000446639, ENSP00000446728, ENSP00000447632, ENSP00000449286, ENSP00000449715, ENSP00000450387, ENSP00000480739, ENSP00000481651, ENSP00000482616, ENSP00000483231, ENSP00000387374, ENSP00000482188, ENSP00000406190, ENSP00000449345, ENSP00000400097, ENSP00000482072, ENSP00000391508, ENSP00000413482, ENSP00000448602, ENSP00000400362, ENSP00000390302, ENSP00000391354, ENSP00000418332, ENSP00000449940, ENSP00000413295, ENSP00000405701, ENSP00000372850, ENSP00000405749, ENSP00000390659, ENSP00000411376, ENSP00000404452, ENSP00000403325, ENSP00000418923, ENSP00000450180, ENSP00000395426, ENSP00000391314, ENSP00000417790, ENSP00000449823, ENSP00000406121, ENSP00000449366, ENSP00000416938, ENSP00000478351, ENSP00000388286, ENSP00000391400, ENSP00000396369, ENSP00000447134, ENSP00000410904, ENSP00000409041, ENSP00000408250, ENSP00000393055, ENSP00000388727, ENSP00000392182, ENSP00000389650, ENSP00000413995, ENSP00000389865, ENSP00000483004, ENSP00000416484, ENSP00000417482, ENSP00000420305, ENSP00000447458, ENSP00000398098, ENSP00000392445, ENSP00000403658, ENSP00000372664, ENSP00000411298, ENSP00000401708, ENSP00000412289, ENSP00000372858, ENSP00000419048, ENSP00000404144
PDB structure ID
2I6S, 3ERB
RefSeq protein ID
NP_000054, NP_001139375, NP_001171534, NP_001269386, NP_001269387, NP_001269388
UniProt protein ID
P06681

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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [5] ↑ . wikidata.org.
  6. [6] ↑ . wikidata.org.
  7. [7] ↑ . wikidata.org.
  8. [8] ↑ . wikidata.org.
  9. [9] ↑ . wikidata.org.
  10. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [13] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . UniProt. Retrieved . wikidata.org.
  16. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . Widespread macromolecular interaction perturbations in human genetic disorders. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [24] ↑ . Type II human complement C2 deficiency. Allele-specific amino acid substitutions (Ser189 --> Phe; Gly444 --> Arg) cause impaired C2 secretion. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [30] ↑ . Type II human complement C2 deficiency. Allele-specific amino acid substitutions (Ser189 --> Phe; Gly444 --> Arg) cause impaired C2 secretion. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [32] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [33] ↑ . UniProt. Retrieved . wikidata.org.
  34. [34] ↑ . UniProt. Retrieved . wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Complement C2. Retrieved October 30, 2026, from https://4ort.xyz/entity/complement-c2-q21102425
MLA “Complement C2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 30 Oct. 2026, https://4ort.xyz/entity/complement-c2-q21102425.
BibTeX @misc{4ortxyz_complement-c2-q21102425_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Complement C2}}, year = {2026}, url = {https://4ort.xyz/entity/complement-c2-q21102425}, note = {Accessed: 2026-10-30}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 15w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon → Homo sapiens
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → peptidase activity, serine-type peptidase activity, hydrolase activity +1
    Encoded by → C2
    + 11 other properties edited (see Wikidata diff for full list)
    "Created claim: EC enzyme number: 3.4.21.43, batch #261488"
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