Complement C1r

mammalian protein found in Homo sapiens
Protein protein Q21111742

Facts

10 properties
Instance of
protein
Part of
Spermadhesin, CUB domain superfamily, Complement C1r subcomponent, Peptidase S1, PA clan, Sushi/SCR/CCP superfamily, CUB domain, protein family, Sushi/SCR/CCP domain, protein family, Serine proteases, trypsin domain, protein family, EGF-like calcium-binding domain, protein family, EGF-like domain, protein family, EGF-like, conserved site, protein family, Serine proteases, trypsin family, serine active site, protein family, EGF-like calcium-binding, conserved site, protein family[2][3][4][5][6][7][8][9][10][11][12][13]
Biological process
immune response, proteolysis, complement activation, classical pathway, immune system process, innate immune response, complement activation, regulation of complement activation, zymogen activation, zymogen activation[34][35][36][37][38][39][40][41]
EC enzyme number
3.4.21.41[23]
Encoded by
C1R[42]
Found in taxon
Homo sapiens[43]
Has part(s)
EGF-type aspartate/asparagine hydroxylation site, EGF-like calcium-binding, conserved site, CUB domain, EGF-like, conserved site, serine proteases, trypsin domain, sushi/SCR/CCP domain, EGF-like calcium-binding domain, EGF-like domain, Serine proteases, trypsin family, serine active site[14][15][16][17][18][19][20][21][22]
Molecular function
peptidase activity, serine-type peptidase activity, serine-type endopeptidase activity, protein binding, hydrolase activity, calcium ion binding, serine-type endopeptidase activity[24][25][26][27][28][29]
Physically interacts with
nafamostat[1]
🏷️ Also known as
en C1R en Complement C1r en complement C1r subcomponent en complement component 1, r subcomponent en Complement component 1 subcomponent r

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References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [1] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  2. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [6] ↑ . wikidata.org.
  7. [7] ↑ . wikidata.org.
  8. [8] ↑ . wikidata.org.
  9. [9] ↑ . wikidata.org.
  10. [10] ↑ . wikidata.org.
  11. [11] ↑ . wikidata.org.
  12. [12] ↑ . wikidata.org.
  13. [13] ↑ . wikidata.org.
  14. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [15] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  16. [16] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  17. [17] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  18. [18] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  19. [19] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  20. [20] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  21. [21] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  22. [22] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  23. [23] ↑ . UniProt. Retrieved . wikidata.org.
  24. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [25] ↑ . Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [27] ↑ . X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [31] ↑ . Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [32] ↑ . In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [33] ↑ . Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [34] ↑ . Familial deficiency of two subunits of the first component of complement. C1r and C1s associated with a lupus erythematosus-like disease. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [37] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [40] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [41] ↑ . Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  42. [42] ↑ . UniProt. Retrieved . wikidata.org.
  43. [43] ↑ . UniProt. Retrieved . wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Complement C1r. Retrieved October 30, 2026, from https://4ort.xyz/entity/complement-c1r
MLA “Complement C1r.” 4ort.xyz Knowledge Graph, 4ort.xyz, 30 Oct. 2026, https://4ort.xyz/entity/complement-c1r.
BibTeX @misc{4ortxyz_complement-c1r_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Complement C1r}}, year = {2026}, url = {https://4ort.xyz/entity/complement-c1r}, note = {Accessed: 2026-10-30}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 15w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Found in taxon → Homo sapiens
    Physically interacts with → nafamostat
    Wikidata description → mammalian protein found in Homo sapiens
    MeSH tree code → D08.811.277.300.280, D12.776.124.486.274.045.280, D12.776.124.486.274.050.280
    + 15 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ EC enzyme number: 3.4.21.41, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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