COMM domain containing 1

mammalian protein found in Mus musculus
Protein Protein Q21496290

Facts

8 properties
Instance of
protein
Part of
COMM domain-containing protein 1, membrane protein, COMMD1 N-terminal domain, protein family, COMM domain, protein family[2][3][4][5]
Biological process
regulation of transcription, DNA-templated, transcription, DNA-templated, protein destabilization, negative regulation of hypoxia-inducible factor-1alpha signaling pathway, plasma membrane to endosome transport, protein transport, negative regulation of NF-kappaB transcription factor activity, Golgi to plasma membrane transport, regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of sodium ion transmembrane transport, positive regulation of protein ubiquitination, negative regulation of protein localization to cell surface, low-density lipoprotein particle clearance, cholesterol homeostasis, regulation of plasma lipoprotein particle levels, positive regulation of cholesterol import, positive regulation of endosome to plasma membrane protein transport, positive regulation of protein localization to cell surface, cellular copper ion homeostasis, copper ion homeostasis
Cell component
cytoplasm, recycling endosome, membrane, Cul2-RING ubiquitin ligase complex, nucleoplasm, early endosome, endosome membrane, cytoplasmic vesicle, nucleus, cytosol, endosome, endosome[20]
Encoded by
Commd1
Found in taxon
house mouse
Has part(s)
COMM domain, COMMD1 N-terminal domain[6][7]
Molecular function
protein homodimerization activity, metal ion binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidic acid binding, sodium channel inhibitor activity, protein binding, identical protein binding, phosphatidylinositol-4,5-bisphosphate binding, copper ion binding, phosphatidylinositol-3,4,5-trisphosphate binding, low-density lipoprotein particle receptor binding[8][9][10][11][12][13][14][15][16][17][18][19]
🏷️ Also known as
en Commd1 en COMM domain containing 1 en COMM domain-containing protein 1 en copper metabolism domain containing 1 en protein Murr1 en U2af1-rs1 region 1
🔖 Identifiers · 3
UniProt protein ID
Q8K4M5

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Summary

COMM domain containing 1 is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . wikidata.org.
  3. [4] ↑ . wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). COMM domain containing 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/comm-domain-containing-1
MLA “COMM domain containing 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/comm-domain-containing-1.
BibTeX @misc{4ortxyz_comm-domain-containing-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{COMM domain containing 1}}, year = {2026}, url = {https://4ort.xyz/entity/comm-domain-containing-1}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): COMM domain containing 1 — https://4ort.xyz/entity/comm-domain-containing-1 (retrieved 2026-05-03)

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