Checkpoint kinase 1

mammalian protein found in Rattus norvegicus

Protein protein Q28556782

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Summary

Checkpoint kinase 1 is a protein^[1].

Key Facts

Checkpoint kinase 1's instance of is recorded as protein^[2].
Checkpoint kinase 1's subclass of is recorded as protein^[3].
Checkpoint kinase 1's UniProt protein ID is recorded as Q91ZN7^[4].
Checkpoint kinase 1's part of is recorded as Protein kinase-like domain superfamily^[5].
Checkpoint kinase 1's part of is recorded as Checkpoint kinase 1, catalytic domain, protein family^[6].
Checkpoint kinase 1's part of is recorded as Protein kinase domain, protein family^[7].
Checkpoint kinase 1's part of is recorded as Protein kinase, ATP binding site, protein family^[8].
Checkpoint kinase 1's part of is recorded as Serine/threonine-protein kinase, active site, protein family^[9].
Checkpoint kinase 1's has part is recorded as protein kinase domain^[10].
Checkpoint kinase 1's has part is recorded as serine/threonine-protein kinase, active site^[11].
Checkpoint kinase 1's has part is recorded as Checkpoint kinase 1, catalytic domain^[12].
Checkpoint kinase 1's has part is recorded as protein kinase, ATP binding site^[13].
Checkpoint kinase 1's RefSeq protein ID is recorded as NP_536325^[14].
Checkpoint kinase 1's RefSeq protein ID is recorded as XP_008764264^[15].
Checkpoint kinase 1's RefSeq protein ID is recorded as XP_008764265^[16].
Checkpoint kinase 1's RefSeq protein ID is recorded as XP_038936651^[17].
Checkpoint kinase 1's RefSeq protein ID is recorded as XP_038936652^[18].
Checkpoint kinase 1's RefSeq protein ID is recorded as XP_038936653^[19].
Checkpoint kinase 1's RefSeq protein ID is recorded as XP_038936654^[20].
Checkpoint kinase 1's molecular function is recorded as nucleotide binding^[21].
Checkpoint kinase 1's molecular function is recorded as protein kinase activity^[22].
Checkpoint kinase 1's molecular function is recorded as protein serine/threonine kinase activity^[23].
Checkpoint kinase 1's molecular function is recorded as protein binding^[24].
Checkpoint kinase 1's molecular function is recorded as ATP binding^[25].
Checkpoint kinase 1's molecular function is recorded as kinase activity^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Subclass of protein

Part of Protein kinase-like domain superfamily, Checkpoint kinase 1, catalytic domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process DNA damage checkpoint signaling, DNA repair, protein phosphorylation, cellular response to DNA damage stimulus, DNA damage induced protein phosphorylation, cell cycle, regulation of double-strand break repair via homologous recombination, regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage, negative regulation of G2/M transition of mitotic cell cycle, phosphorylation, peptidyl-threonine phosphorylation, intracellular signal transduction, negative regulation of mitotic nuclear division, regulation of mitotic centrosome separation, cellular response to organic substance, cellular response to caffeine, negative regulation of DNA biosynthetic process, regulation of histone H3-K9 acetylation

Cell component chromatin, condensed nuclear chromosome, cellular component, nucleus, cytoplasm, centrosome, microtubule organizing center, cytoskeleton

Encoded by Chek1

Found in taxon brown rat

Has part(s) protein kinase domain, serine/threonine-protein kinase, active site, Checkpoint kinase 1, catalytic domain, protein kinase, ATP binding site

Imported from wholeness_audit_2026-05-02

Molecular function nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, protein binding, ATP binding, kinase activity, transferase activity, histone kinase activity (H3-T11 specific)

External References (3)

Ensembl protein id ENSRNOP00000083121, ENSRNOP00000070708, ENSRNOP00000011226

Refseq protein id NP_536325, XP_008764264, XP_008764265, XP_038936651, XP_038936652, XP_038936653, XP_038936654

Uniprot protein id Q91ZN7

🏷️ Also known as

en Checkpoint kinase 1 en checkpoint kinase 1 homolog en Chek1 en CHK1 checkpoint homolog en serine/threonine-protein kinase Chk1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Checkpoint kinase 1 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Checkpoint kinase 1 — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Checkpoint kinase 1 — UniProt protein ID (P352): Q91ZN7. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Checkpoint kinase 1 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Checkpoint kinase 1 — part of (P361): Checkpoint kinase 1, catalytic domain, protein family. wikidata.org.
[7] ↑ Checkpoint kinase 1 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[8] ↑ Checkpoint kinase 1 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[9] ↑ Checkpoint kinase 1 — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[10] ↑ Checkpoint kinase 1 — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Checkpoint kinase 1 — has part(s) (P527): serine/threonine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Checkpoint kinase 1 — has part(s) (P527): Checkpoint kinase 1, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Checkpoint kinase 1 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Checkpoint kinase 1 — RefSeq protein ID (P637): NP_536325. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Checkpoint kinase 1 — RefSeq protein ID (P637): XP_008764264. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Checkpoint kinase 1 — RefSeq protein ID (P637): XP_008764265. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Checkpoint kinase 1 — RefSeq protein ID (P637): XP_038936651. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Checkpoint kinase 1 — RefSeq protein ID (P637): XP_038936652. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Checkpoint kinase 1 — RefSeq protein ID (P637): XP_038936653. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Checkpoint kinase 1 — RefSeq protein ID (P637): XP_038936654. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Checkpoint kinase 1 — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Checkpoint kinase 1 — molecular function (P680): protein kinase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Checkpoint kinase 1 — molecular function (P680): protein serine/threonine kinase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Checkpoint kinase 1 — molecular function (P680): protein binding. Cloning and Characterization of Liver-specific Isoform of Chk1 Gene from Rat. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Checkpoint kinase 1 — molecular function (P680): ATP binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Checkpoint kinase 1 — molecular function (P680): kinase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Checkpoint kinase 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Checkpoint kinase 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/checkpoint-kinase-1-q28556782

MLA

“Checkpoint kinase 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/checkpoint-kinase-1-q28556782.

BibTeX

@misc{4ortxyz_checkpoint-kinase-1-q28556782_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Checkpoint kinase 1}}, year = {2026}, url = {https://4ort.xyz/entity/checkpoint-kinase-1-q28556782}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Checkpoint kinase 1 — https://4ort.xyz/entity/checkpoint-kinase-1-q28556782 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/checkpoint-kinase-1-q28556782 · Last refreshed: May 3, 2026