Checkpoint kinase 1

mammalian protein found in Homo sapiens

Protein protein Q21109168

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Checkpoint kinase 1

Summary

Checkpoint kinase 1 is a protein^[1]. It is known by 8 alternative names across languages and contexts.^[2]

Key Facts

Checkpoint kinase 1's instance of is recorded as protein^[3].
Checkpoint kinase 1 is part of Protein kinase-like domain superfamily^[4].
Checkpoint kinase 1 is part of Checkpoint kinase 1, catalytic domain, protein family^[5].
Checkpoint kinase 1 is part of Protein kinase domain, protein family^[6].
Checkpoint kinase 1 is part of Protein kinase, ATP binding site, protein family^[7].
Checkpoint kinase 1 is part of Serine/threonine-protein kinase, active site, protein family^[8].
Checkpoint kinase 1 comprises protein kinase domain^[9].
Checkpoint kinase 1 comprises protein kinase, ATP binding site^[10].
Checkpoint kinase 1 comprises serine/threonine-protein kinase, active site^[11].
Checkpoint kinase 1 comprises Checkpoint kinase 1, catalytic domain^[12].

Why It Matters

Checkpoint kinase 1 is known by 8 alternative names across languages and contexts.^[2]

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of Protein kinase-like domain superfamily, Checkpoint kinase 1, catalytic domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process regulation of mitotic centrosome separation, regulation of double-strand break repair via homologous recombination, phosphorylation, replicative senescence, cellular response to DNA damage stimulus, DNA replication, protein phosphorylation, cellular response to mechanical stimulus, negative regulation of mitotic nuclear division, DNA damage induced protein phosphorylation, cell cycle, peptidyl-threonine phosphorylation, regulation of signal transduction by p53 class mediator, DNA repair, intracellular signal transduction, regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage, regulation of histone H3-K9 acetylation, DNA damage checkpoint signaling, positive regulation of cell cycle, apoptotic process, negative regulation of G0 to G1 transition, protein phosphorylation, mitotic G2 DNA damage checkpoint signaling

Cell component cytosol, centrosome, intracellular membrane-bounded organelle, nucleoplasm, microtubule organizing center, condensed nuclear chromosome, telomere, cytoskeleton, nucleus, extracellular space, chromatin, cytoplasm, extracellular space, nucleus, cytoplasm, protein-containing complex

Ec enzyme number 2.7.11.1

Encoded by CHEK1

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) protein kinase domain, protein kinase, ATP binding site, serine/threonine-protein kinase, active site, Checkpoint kinase 1, catalytic domain

Molecular function transferase activity, protein kinase activity, nucleotide binding, protein binding, ATP binding, kinase activity, protein serine/threonine kinase activity, histone kinase activity (H3-T11 specific), protein domain specific binding, protein serine/threonine kinase activity

External References (7)

Ensembl protein id ENSP00000388648, ENSP00000412504, ENSP00000432890, ENSP00000435371, ENSP00000442317, ENSP00000481616, ENSP00000278916, ENSP00000391090, ENSP00000431525, ENSP00000431815, ENSP00000432470, ENSP00000434141, ENSP00000434646, ENSP00000477588

Mesh descriptor id D000071877

Mesh tree code D08.811.913.696.620.682.700.143, D12.776.476.563.143

Pdb structure id 1IA8, 1NVQ, 1NVR, 1NVS, 1ZLT, 1ZYS, 2AYP, 2BR1, 2BRB, 2BRG, 2BRH, 2BRM, 2BRN, 2BRO, 2C3J, 2C3K, 2C3L, 2CGU, 2CGV, 2CGW, 2CGX, 2E9N, 2E9O, 2E9P, 2E9U, 2E9V, 2GDO, 2GHG, 2HOG, 2HXL, 2HXQ, 2HY0, 2QHM, 2QHN, 2R0U, 2WMQ, 2WMR, 2WMS, 2WMT, 2WMU, 2WMV, 2WMW, 2WMX, 2X8D, 2X8E, 2X8I, 2XEY, 2XEZ, 2XF0, 2YDI, 2YDJ, 2YDK, 2YER, 2YEX, 2YM3, 2YM4, 2YM5, 2YM6, 2YM7, 2YM8, 2YWP, 3F9N, 3JVR, 3JVS, 3NLB, 3OT3, 3OT8, 3PA3, 3PA4, 3PA5, 3TKH, 3TKI, 3U9N, 4FSM, 4FSN, 4FSQ, 4FSR, 4FST, 4FSU, 4FSW, 4FSY, 4FSZ, 4FT0, 4FT3, 4FT5, 4FT7, 4FT9, 4FTA, 4FTC, 4FTI, 4FTJ, 4FTK, 4FTL, 4FTM, 4FTN, 4FTO, 4FTQ, 4FTR, 4FTT, 4FTU, 4GH2, 4HYH, 4HYI, 4JIK, 4QYE, 4QYF, 4QYG, 4QYH, 4RVK, 4RVL, 4RVM, 5DLS, 5F4N

Refseq protein id NP_001107593, NP_001107594, NP_001231775, NP_001265, NP_001317356, NP_001317357, XP_011540862, XP_016872635, XP_024304105

Umls cui C0216510

Uniprot protein id O14757

🏷️ Also known as

en cell cycle checkpoint kinase en Checkpoint kinase 1 en Checkpoint kinase-1 en Checkpoint, S. pombe, homolog of, 1 en CHEK1 en CHK1 checkpoint homolog en Chk1-S en serine/threonine-protein kinase Chk1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Checkpoint kinase 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/checkpoint-kinase-1

MLA “Checkpoint kinase 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/checkpoint-kinase-1.

BibTeX

@misc{4ortxyz_checkpoint-kinase-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Checkpoint kinase 1}}, year = {2026}, url = {https://4ort.xyz/entity/checkpoint-kinase-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Checkpoint kinase 1 — https://4ort.xyz/entity/checkpoint-kinase-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/checkpoint-kinase-1 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

7w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Found in taxon → Homo sapiens

Mesh tree code → D08.811.913.696.620.682.700.143, D12.776.476.563.143

Wikidata description → mammalian protein found in Homo sapiens

Pdb structure id → 1IA8, 1NVQ, 1NVR +110

+ 15 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.11.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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Checkpoint kinase 1

Checkpoint kinase 1

Summary

Key Facts

Why It Matters

References

Direct Wikidata claims

Class ancestry

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