cellular communication network factor 2

mammalian protein found in Homo sapiens

Protein protein Q5014566

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cellular communication network factor 2

Summary

cellular communication network factor 2 is a protein^[1].

Key Facts

cellular communication network factor 2's instance of is recorded as protein^[2].
cellular communication network factor 2's UniProt protein ID is recorded as P29279^[3].
cellular communication network factor 2's part of is recorded as IGFBP-related, CNN^[4].
cellular communication network factor 2's part of is recorded as Thrombospondin type-1 (TSP1) repeat superfamily^[5].
cellular communication network factor 2's part of is recorded as Growth factor receptor cysteine-rich domain superfamily^[6].
cellular communication network factor 2's part of is recorded as Glycoprotein hormone subunit beta, protein family^[7].
cellular communication network factor 2's part of is recorded as VWFC domain, protein family^[8].
cellular communication network factor 2's part of is recorded as Cystine knot, C-terminal domain, protein family^[9].
cellular communication network factor 2's part of is recorded as Insulin-like growth factor-binding protein, IGFBP family^[10].
cellular communication network factor 2's part of is recorded as Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site, protein family^[11].
cellular communication network factor 2's part of is recorded as Thrombospondin type-1 (TSP1) repeat, protein family^[12].
cellular communication network factor 2's MeSH descriptor ID is recorded as D055513^[13].
cellular communication network factor 2's has part is recorded as Thrombospondin type-1 (TSP1) repeat^[14].
cellular communication network factor 2's has part is recorded as Glycoprotein hormone subunit beta^[15].
cellular communication network factor 2's has part is recorded as Insulin-like growth factor-binding protein, IGFBP^[16].
cellular communication network factor 2's has part is recorded as Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site^[17].
cellular communication network factor 2's has part is recorded as Cystine knot, C-terminal^[18].
cellular communication network factor 2's has part is recorded as VWFC domain^[19].
cellular communication network factor 2's RefSeq protein ID is recorded as NP_001892^[20].
cellular communication network factor 2's MeSH tree code is recorded as D12.644.276.200.100^[21].
cellular communication network factor 2's MeSH tree code is recorded as D12.776.467.200.100^[22].
cellular communication network factor 2's MeSH tree code is recorded as D12.776.860.300.200.100^[23].
cellular communication network factor 2's MeSH tree code is recorded as D23.529.237.100^[24].
cellular communication network factor 2's molecular function is recorded as fibronectin binding^[25].
cellular communication network factor 2's molecular function is recorded as insulin-like growth factor binding^[26].

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Quick Facts

Instance of protein

Part of IGFBP-related, CNN, Thrombospondin type-1 (TSP1) repeat superfamily, Growth factor receptor cysteine-rich domain superfamily, Glycoprotein hormone subunit beta, protein family, VWFC domain, protein family, Cystine knot, C-terminal domain, protein family, Insulin-like growth factor-binding protein, IGFBP family, Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site, protein family, Thrombospondin type-1 (TSP1) repeat, protein family

Properties

Biological process positive regulation of collagen biosynthetic process, positive regulation of cell activation, cell differentiation, regulation of chondrocyte differentiation, response to amino acid, response to estradiol, response to anoxia, intracellular signal transduction, response to mineralocorticoid, response to fatty acid, DNA biosynthetic process, positive regulation of cell death, ossification, response to organic cyclic compound, extracellular matrix constituent secretion, lung development, response to peptide hormone, positive regulation of G0 to G1 transition, positive regulation of JNK cascade, response to glucose, negative regulation of gene expression, reactive oxygen species metabolic process, fibroblast growth factor receptor signaling pathway, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of gene expression, connective tissue development, response to wounding, regulation of cell growth, angiogenesis, tissue homeostasis, positive regulation of cell population proliferation, chondrocyte proliferation, positive regulation of cell differentiation, epidermis development, positive regulation of cardiac muscle contraction, positive regulation of ERK1 and ERK2 cascade, positive regulation of protein phosphorylation, integrin-mediated signaling pathway, transcription initiation from RNA polymerase II promoter, cell-matrix adhesion, cell migration, cartilage condensation, positive regulation of stress fiber assembly, ageing, cell adhesion, cell-cell signaling, negative regulation of cell death, regulation of signaling receptor activity

Cell component cytosol, cis-Golgi network, plasma membrane, extracellular region, cell cortex, perinuclear region of cytoplasm, extracellular space, extracellular matrix, extracellular matrix, extracellular matrix, collagen-containing extracellular matrix

Encoded by CCN2

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Has part(s) Thrombospondin type-1 (TSP1) repeat, Glycoprotein hormone subunit beta, Insulin-like growth factor-binding protein, IGFBP, Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site, Cystine knot, C-terminal, VWFC domain

Imported from wholeness_audit_2026-05-02

Molecular function fibronectin binding, insulin-like growth factor binding, protein C-terminus binding, protein binding, growth factor activity, integrin binding, heparin binding

External References (6)

Ensembl protein id ENSP00000356954

Mesh descriptor id D055513

Mesh tree code D12.644.276.200.100, D12.776.467.200.100, D12.776.860.300.200.100, D23.529.237.100

Refseq protein id NP_001892

Umls cui C0110610

Uniprot protein id P29279

🏷️ Also known as

en CCN2 en CCN family member 2 en cellular communication network factor 2 en connective tissue growth factor en CTGF en hypertrophic chondrocyte-specific protein 24 en IBP-8 en IGF-binding protein 8 en IGFBP-8 en insulin-like growth factor-binding protein 8

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ cellular communication network factor 2 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ cellular communication network factor 2 — UniProt protein ID (P352): P29279. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ cellular communication network factor 2 — part of (P361): IGFBP-related, CNN. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ cellular communication network factor 2 — part of (P361): Thrombospondin type-1 (TSP1) repeat superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ cellular communication network factor 2 — part of (P361): Growth factor receptor cysteine-rich domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ cellular communication network factor 2 — part of (P361): Glycoprotein hormone subunit beta, protein family. wikidata.org.
[8] ↑ cellular communication network factor 2 — part of (P361): VWFC domain, protein family. wikidata.org.
[9] ↑ cellular communication network factor 2 — part of (P361): Cystine knot, C-terminal domain, protein family. wikidata.org.
[10] ↑ cellular communication network factor 2 — part of (P361): Insulin-like growth factor-binding protein, IGFBP family. wikidata.org.
[11] ↑ cellular communication network factor 2 — part of (P361): Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site, protein family. wikidata.org.
[12] ↑ cellular communication network factor 2 — part of (P361): Thrombospondin type-1 (TSP1) repeat, protein family. wikidata.org.
[13] ↑ cellular communication network factor 2 — MeSH descriptor ID (P486): D055513. wikidata.org.
[14] ↑ cellular communication network factor 2 — has part(s) (P527): Thrombospondin type-1 (TSP1) repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ cellular communication network factor 2 — has part(s) (P527): Glycoprotein hormone subunit beta. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ cellular communication network factor 2 — has part(s) (P527): Insulin-like growth factor-binding protein, IGFBP. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ cellular communication network factor 2 — has part(s) (P527): Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ cellular communication network factor 2 — has part(s) (P527): Cystine knot, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ cellular communication network factor 2 — has part(s) (P527): VWFC domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ cellular communication network factor 2 — RefSeq protein ID (P637): NP_001892. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ cellular communication network factor 2 — MeSH tree code (P672): D12.644.276.200.100. wikidata.org.
[22] ↑ cellular communication network factor 2 — MeSH tree code (P672): D12.776.467.200.100. wikidata.org.
[23] ↑ cellular communication network factor 2 — MeSH tree code (P672): D12.776.860.300.200.100. wikidata.org.
[24] ↑ cellular communication network factor 2 — MeSH tree code (P672): D23.529.237.100. wikidata.org.
[25] ↑ cellular communication network factor 2 — molecular function (P680): fibronectin binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ cellular communication network factor 2 — molecular function (P680): insulin-like growth factor binding. Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ cellular communication network factor 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). cellular communication network factor 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/cellular-communication-network-factor-2

MLA

“cellular communication network factor 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/cellular-communication-network-factor-2.

BibTeX

@misc{4ortxyz_cellular-communication-network-factor-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{cellular communication network factor 2}}, year = {2026}, url = {https://4ort.xyz/entity/cellular-communication-network-factor-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): cellular communication network factor 2 — https://4ort.xyz/entity/cellular-communication-network-factor-2 (retrieved 2026-05-03)

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