CD74 molecule
mammalian protein found in Homo sapiens
Facts
9 properties- Instance of
- protein
- Part of
- Thyroglobulin type-1 superfamily, MHC class II-associated invariant chain, trimerisation domain superfamily, MHC class II-associated invariant chain, MHC class II-associated invariant chain, trimerisation, protein family, Thyroglobulin type-1, protein family, MHC class II-associated invariant chain/CLIP, MHC II-interacting, protein family[2][3][4][5][6][7]
- Biological process
- immune response, positive regulation of T cell differentiation, negative regulation of apoptotic process, signal transduction, positive thymic T cell selection, chaperone cofactor-dependent protein refolding, T cell selection, positive regulation of type 2 immune response, positive regulation of dendritic cell antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, adaptive immune response, antigen processing and presentation, positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of mature B cell apoptotic process, regulation of macrophage activation, negative regulation of DNA damage response, signal transduction by p53 class mediator, immunoglobulin mediated immune response, leukocyte migration, positive regulation of neutrophil chemotaxis, positive regulation of chemokine (C-X-C motif) ligand 2 production, macrophage migration inhibitory factor signaling pathway, prostaglandin biosynthetic process, cell population proliferation, antigen processing and presentation of endogenous antigen, immune system process, defense response, negative regulation of peptide secretion, negative regulation of T cell differentiation, positive regulation of macrophage cytokine production, positive regulation of B cell proliferation, negative thymic T cell selection, positive regulation of fibroblast proliferation, intracellular protein transport, positive regulation of ERK1 and ERK2 cascade, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of cytokine-mediated signaling pathway, positive regulation of protein phosphorylation, positive regulation of kinase activity, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of MAPK cascade, positive regulation of monocyte differentiation, positive regulation of transcription, DNA-templated, positive regulation of viral entry into host cell, protein heterotetramerization, protein trimerization, protein-containing complex assembly
- Cell component
- lysosomal lumen, extracellular exosome, MHC class II protein complex, lysosomal membrane, late endosome, endocytic vesicle membrane, transport vesicle membrane, integral component of membrane, ER to Golgi transport vesicle membrane, multivesicular body, Golgi apparatus, Golgi membrane, trans-Golgi network membrane, macrophage migration inhibitory factor receptor complex, membrane, cell surface, intracellular anatomical structure, integral component of lumenal side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, plasma membrane, lysosome, vacuole, endosome, clathrin-coated endocytic vesicle membrane, NOS2-CD74 complex, external side of plasma membrane, membrane, extracellular exosome
- Encoded by
- CD74
- Found in taxon
- Homo sapiens
- Has part(s)
- MHC class II-associated invariant chain, trimerisation, MHC class II-associated invariant chain/CLIP, MHC II-interacting, Thyroglobulin type-1[8][9][10]
- Has parts
- MHC class II-associated invariant chain, trimerisation, MHC class II-associated invariant chain/CLIP, MHC II-interacting, Thyroglobulin type-1
- Molecular function
- nitric-oxide synthase binding, identical protein binding, MHC class II protein binding, via antigen binding groove, cytokine receptor activity, macrophage migration inhibitory factor binding, protein folding chaperone activity, MHC class II protein complex binding, amyloid-beta binding, protein binding, MHC class II protein binding, cytokine binding, CD4 receptor binding
🏷️ Also known as
en CD74
en CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
en CD74 molecule
en CD74 molecule, major histocompatibility complex, class II invariant chain
en gamma chain of class II antigens
en HLA class II histocompatibility antigen gamma chain
en HLA-DR antigens-associated invariant chain
en HLA-DR-gamma
en Ia antigen-associated invariant chain
en Ia-associated invariant chain
en Ii
en MHC HLA-DR gamma chain
en p33
zh CD74基因
zh 恒定链
🔖 Identifiers · 9
- OpenAlex ID
- C119997001
- Ensembl protein ID
- ENSP00000009530, ENSP00000230685, ENSP00000367026, ENSP00000429024, ENSP00000429478, ENSP00000429641, ENSP00000430614, ENSP00000430654
- Exact match
- identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov
- Freebase ID
- /m/03cv_n2
- Microsoft Academic ID (discontinued)
- 119997001
- RefSeq protein ID
- NP_001020329, NP_001020330, NP_004346, XP_016865578, XP_016865579, NP_001351012, NP_001351013
- Transporter Classification Database ID
- 9.A.75.1.1
- UniProt protein ID
- P04233
🔗 Connections
Cell component 9
Biological process 3
Found in taxon 1
Instance of 1
Molecular function 1
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Summary
CD74 molecule is a protein[1].