CD3 antigen, epsilon polypeptide

mammalian protein found in Mus musculus
Protein Protein Q21981008

Facts

8 properties
Instance of
protein
Part of
CD3 protein, epsilon/gamma/delta subunit, Immunoglobulin-like fold, Immunoglobulin-like domain superfamily, membrane protein, Immunoglobulin subtype 2, protein family, immunoglobulin-like domain, protein family, Phosphorylated immunoreceptor signalling ITAM, protein family[2][3][4][5][6][7][8]
Biological process
lymphocyte activation, T cell costimulation, T cell differentiation in thymus, positive regulation of calcium-mediated signaling, positive regulation of alpha-beta T cell proliferation, positive regulation of interferon-gamma production, positive regulation of interleukin-4 production, positive regulation of T cell anergy, cell surface receptor signaling pathway, positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of smoothened signaling pathway, apoptotic signaling pathway, positive regulation of T cell activation, T cell receptor signaling pathway, immune system process, negative thymic T cell selection, negative regulation of gene expression, positive regulation of gene expression, positive regulation of T cell proliferation, response to nutrient, protein homooligomerization, positive regulation of cell-matrix adhesion, adaptive immune response, cell surface receptor signaling pathway, response to nutrient, dendrite development, cerebellum development, T cell differentiation, positive regulation of cell-cell adhesion mediated by integrin, positive thymic T cell selection, response to nutrient
Cell component
integral component of membrane, cell-cell junction, membrane, alpha-beta T cell receptor complex, immunological synapse, plasma membrane, T cell receptor complex, external side of plasma membrane, plasma membrane, external side of plasma membrane, alpha-beta T cell receptor complex, dendritic spine, cell body
Encoded by
Cd3e
Found in taxon
house mouse
Has part(s)
Phosphorylated immunoreceptor signalling ITAM, immunoglobulin subtype 2, immunoglobulin-like domain[9][10][11]
Molecular function
signal transducer activity, transmembrane signaling receptor activity, protein binding, SH3 domain binding, protein heterodimerization activity, protein homodimerization activity, transmembrane signaling receptor activity[12][13][14][15][16][17][18]
🏷️ Also known as
en CD3 antigen, epsilon polypeptide en Cd3e en T-cell surface antigen T3/Leu-4 epsilon chain en T-cell surface glycoprotein CD3 epsilon chain
🔖 Identifiers · 4
Ensembl protein ID
ENSMUSP00000099896
PDB structure ID
1JBJ, 1XMW, 2K4F, 3R08
RefSeq protein ID
NP_031674, XP_006510029
UniProt protein ID
P22646

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Summary

CD3 antigen, epsilon polypeptide is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . wikidata.org.
  7. [8] ↑ . wikidata.org.
  8. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . Essential role for ZAP-70 in both positive and negative selection of thymocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). CD3 antigen, epsilon polypeptide. Retrieved May 3, 2026, from https://4ort.xyz/entity/cd3-antigen-epsilon-polypeptide
MLA “CD3 antigen, epsilon polypeptide.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/cd3-antigen-epsilon-polypeptide.
BibTeX @misc{4ortxyz_cd3-antigen-epsilon-polypeptide_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{CD3 antigen, epsilon polypeptide}}, year = {2026}, url = {https://4ort.xyz/entity/cd3-antigen-epsilon-polypeptide}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): CD3 antigen, epsilon polypeptide — https://4ort.xyz/entity/cd3-antigen-epsilon-polypeptide (retrieved 2026-05-03)

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