CCAAT enhancer binding protein alpha

mammalian protein found in Homo sapiens

Protein protein Q21116819

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CCAAT enhancer binding protein alpha

Summary

CCAAT enhancer binding protein alpha is a protein^[1].

Key Facts

CCAAT enhancer binding protein alpha's instance of is recorded as protein^[2].
CCAAT enhancer binding protein alpha's UniProt protein ID is recorded as P49715^[3].
CCAAT enhancer binding protein alpha's part of is recorded as CCAAT/enhancer-binding protein, chordates^[4].
CCAAT enhancer binding protein alpha's part of is recorded as Basic-leucine zipper domain, protein family^[5].
CCAAT enhancer binding protein alpha's MeSH descriptor ID is recorded as D022763^[6].
CCAAT enhancer binding protein alpha's has part is recorded as Basic-leucine zipper domain^[7].
CCAAT enhancer binding protein alpha's RefSeq protein ID is recorded as NP_001272758^[8].
CCAAT enhancer binding protein alpha's RefSeq protein ID is recorded as NP_001274353^[9].
CCAAT enhancer binding protein alpha's RefSeq protein ID is recorded as NP_001274364^[10].
CCAAT enhancer binding protein alpha's RefSeq protein ID is recorded as NP_004355^[11].
CCAAT enhancer binding protein alpha's MeSH tree code is recorded as D12.776.260.108.124.500^[12].
CCAAT enhancer binding protein alpha's MeSH tree code is recorded as D12.776.660.167.500^[13].
CCAAT enhancer binding protein alpha's MeSH tree code is recorded as D12.776.930.127.124.500^[14].
CCAAT enhancer binding protein alpha's molecular function is recorded as DNA binding^[15].
CCAAT enhancer binding protein alpha's molecular function is recorded as sequence-specific DNA binding^[16].
CCAAT enhancer binding protein alpha's molecular function is recorded as protein homodimerization activity^[17].
CCAAT enhancer binding protein alpha's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[18].
CCAAT enhancer binding protein alpha's molecular function is recorded as DNA-binding transcription factor activity^[19].
CCAAT enhancer binding protein alpha's molecular function is recorded as transcription coactivator activity^[20].
CCAAT enhancer binding protein alpha's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[21].
CCAAT enhancer binding protein alpha's molecular function is recorded as transcription factor binding^[22].
CCAAT enhancer binding protein alpha's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[23].
CCAAT enhancer binding protein alpha's molecular function is recorded as kinase binding^[24].
CCAAT enhancer binding protein alpha's molecular function is recorded as protein binding^[25].
CCAAT enhancer binding protein alpha's molecular function is recorded as transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding^[26].

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Quick Facts

Instance of protein

Part of CCAAT/enhancer-binding protein, chordates, Basic-leucine zipper domain, protein family

Properties

Biological process Notch signaling pathway, transcription by RNA polymerase I, myeloid cell differentiation, regulation of transcription, DNA-templated, cellular response to lithium ion, glucose homeostasis, negative regulation of cyclin-dependent protein serine/threonine kinase activity, lung development, cytokine-mediated signaling pathway, urea cycle, regulation of transcription by RNA polymerase II, cellular response to organic cyclic compound, mitochondrion organization, embryonic placenta development, cholesterol metabolic process, negative regulation of cell cycle, negative regulation of transcription by RNA polymerase II, cell maturation, generation of precursor metabolites and energy, transcription, DNA-templated, macrophage differentiation, multicellular organism development, positive regulation of transcription, DNA-templated, positive regulation of osteoblast differentiation, granulocyte differentiation, regulation of cell population proliferation, brown fat cell differentiation, lipid homeostasis, white fat cell differentiation, inner ear development, liver development, viral process, negative regulation of transcription, DNA-templated, positive regulation of fat cell differentiation, positive regulation of transcription by RNA polymerase III, fat cell differentiation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, negative regulation of cell population proliferation, transcription by RNA polymerase II, cellular response to tumor necrosis factor, positive regulation of DNA-templated transcription, initiation, transcription, DNA-templated, positive regulation of macrophage activation, positive regulation of inflammatory response, positive regulation of transcription by RNA polymerase II, interleukin-6-mediated signaling pathway

Cell component transcription regulator complex, RNA polymerase II transcription regulator complex, nucleolus, nucleus, nucleoplasm, intracellular membrane-bounded organelle, nucleolus, transcription regulator complex

Encoded by CEBPA

Found in taxon Homo sapiens

Has part(s) Basic-leucine zipper domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, sequence-specific DNA binding, protein homodimerization activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, transcription coactivator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, kinase binding, protein binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (6)

Ensembl protein id ENSP00000427514

Mesh descriptor id D022763

Mesh tree code D12.776.260.108.124.500, D12.776.660.167.500, D12.776.930.127.124.500

Refseq protein id NP_001272758, NP_001274353, NP_001274364, NP_004355

Umls cui C0378310

Uniprot protein id P49715

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ CCAAT enhancer binding protein alpha — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ CCAAT enhancer binding protein alpha — UniProt protein ID (P352): P49715. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ CCAAT enhancer binding protein alpha — part of (P361): CCAAT/enhancer-binding protein, chordates. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ CCAAT enhancer binding protein alpha — part of (P361): Basic-leucine zipper domain, protein family. wikidata.org.
[6] ↑ CCAAT enhancer binding protein alpha — MeSH descriptor ID (P486): D022763. wikidata.org.
[7] ↑ CCAAT enhancer binding protein alpha — has part(s) (P527): Basic-leucine zipper domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ CCAAT enhancer binding protein alpha — RefSeq protein ID (P637): NP_001272758. Q20641742. Retrieved 2020-05-30. wikidata.org.
[9] ↑ CCAAT enhancer binding protein alpha — RefSeq protein ID (P637): NP_001274353. Q20641742. Retrieved 2020-05-30. wikidata.org.
[10] ↑ CCAAT enhancer binding protein alpha — RefSeq protein ID (P637): NP_001274364. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ CCAAT enhancer binding protein alpha — RefSeq protein ID (P637): NP_004355. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ CCAAT enhancer binding protein alpha — MeSH tree code (P672): D12.776.260.108.124.500. wikidata.org.
[13] ↑ CCAAT enhancer binding protein alpha — MeSH tree code (P672): D12.776.660.167.500. wikidata.org.
[14] ↑ CCAAT enhancer binding protein alpha — MeSH tree code (P672): D12.776.930.127.124.500. wikidata.org.
[15] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): DNA binding. The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): protein homodimerization activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): DNA-binding transcription factor activity. Transcription factor C/EBPalpha: novel sites of expression and cloning of the human gene. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): transcription coactivator activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): transcription factor binding. Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): kinase binding. Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): protein binding. Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ CCAAT enhancer binding protein alpha — molecular function (P680): transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha). Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ CCAAT enhancer binding protein alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_ccaat-enhancer-binding-protein-alpha-q21116819_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{CCAAT enhancer binding protein alpha}}, year = {2026}, url = {https://4ort.xyz/entity/ccaat-enhancer-binding-protein-alpha-q21116819}, note = {Accessed: 2026-05-03}}

LLM prompt

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