catenin beta 1
mammalian protein found in Homo sapiens
Facts
8 properties- Instance of
- protein
- Part of
- beta-catenin, Armadillo-like helical, Armadillo-type fold, armadillo domain proteins, Armadillo domain, protein family[1][2][3][4][5]
- Biological process
- embryonic brain development, negative regulation of cell population proliferation, renal vesicle formation, positive regulation of MAPK cascade, proximal/distal pattern formation, positive regulation of neuroblast proliferation, chemical synaptic transmission, central nervous system vasculogenesis, renal inner medulla development, transcription, DNA-templated, positive regulation of neuron apoptotic process, canonical Wnt signaling pathway, embryonic foregut morphogenesis, endoderm formation, endodermal cell fate commitment, synapse organization, trachea formation, cellular process or phenomenon, positive regulation of telomere maintenance via telomerase, neural plate development, negative regulation of protein sumoylation, lung cell differentiation, vasculogenesis, lung induction, hemopoiesis, kidney development, positive regulation of gene expression, adherens junction organization, renal outer medulla development, thymus development, regulation of myelination, positive regulation of cell population proliferation, epithelial tube branching involved in lung morphogenesis, bone resorption, epithelial cell differentiation involved in prostate gland development, regulation of euchromatin binding, hair follicle morphogenesis, hair follicle placode formation, neuron migration, negative regulation of chondrocyte differentiation, fungiform papilla formation, positive regulation of type I interferon production, negative regulation of mitotic cell cycle, embryonic, ectoderm development, trachea morphogenesis, T cell differentiation in thymus, pancreas development, cranial ganglion development, regulation of apoptotic process, lung development, positive regulation of skeletal muscle tissue development, synaptic vesicle transport, positive regulation of telomerase activity, morphogenesis of embryonic epithelium, renal system development, oocyte development, hair cycle process, embryonic axis specification, embryonic forelimb morphogenesis, anterior/posterior axis specification, positive regulation of endothelial cell differentiation, regulation of transcription by RNA polymerase II, animal organ development, negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, dorsal/ventral axis specification, positive regulation of muscle cell differentiation, positive regulation of apoptotic process, regulation of protein localization to cell surface, androgen receptor signaling pathway, nervous system development, forebrain development, hair cell differentiation, negative regulation of transcription by RNA polymerase II, regulation of epithelial cell differentiation, positive regulation of histone H3-K4 methylation, embryonic digit morphogenesis, endothelial tube morphogenesis, osteoclast differentiation, regulation of transcription, DNA-templated, regulation of osteoclast differentiation, neuron differentiation, epithelial to mesenchymal transition, cell fate specification, odontogenesis of dentin-containing tooth, midbrain development, positive regulation of mesenchymal cell proliferation, positive regulation of heparan sulfate proteoglycan biosynthetic process, smooth muscle cell differentiation, glial cell fate determination, cell fate determination, positive regulation of determination of dorsal identity, regulation of T cell proliferation, gastrulation with mouth forming second, negative regulation of apoptotic signaling pathway, oviduct development, cellular response to growth factor stimulus, male genitalia development, negative regulation of gene expression, nephron tubule formation, regulation of osteoblast differentiation, regulation of angiogenesis, cell morphogenesis involved in differentiation, cell-matrix adhesion, dorsal root ganglion development, regulation of cell population proliferation, embryonic skeletal limb joint morphogenesis, development of the heart, T cell differentiation, dorsal/ventral pattern formation, layer formation in cerebral cortex, canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation, canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition, positive regulation of osteoblast differentiation, negative regulation of osteoclast differentiation, regulation of core promoter binding, genitalia morphogenesis, negative regulation of neuron death, cell maturation, cell population proliferation, branching involved in ureteric bud morphogenesis, cell differentiation, protein localization to cell surface, embryonic hindlimb morphogenesis, negative regulation of oligodendrocyte differentiation, metanephros morphogenesis, regulation of centriole-centriole cohesion, limb development, positive regulation of epithelial cell proliferation involved in prostate gland development, regulation of secondary heart field cardioblast proliferation, regulation of fibroblast proliferation, regulation of smooth muscle cell proliferation, skin development, skeletal system development, hindbrain development, regulation of calcium ion import, mesenchymal cell proliferation involved in lung development, regulation of nephron tubule epithelial cell differentiation, cellular response to indole-3-methanol, canonical Wnt signaling pathway involved in negative regulation of apoptotic process, regulation of gene expression, regulation of cell differentiation, stem cell population maintenance, regulation of neurogenesis, in utero embryonic development, lung-associated mesenchyme development, negative regulation of cell differentiation, positive regulation of I-kappaB kinase/NF-kappaB signaling, vasculature development, sympathetic ganglion development, positive regulation of epithelial cell differentiation, positive regulation of branching involved in lung morphogenesis, lens morphogenesis in camera-type eye, positive regulation of epithelial to mesenchymal transition, positive regulation of fibroblast growth factor receptor signaling pathway, embryonic heart tube development, regulation of centromeric sister chromatid cohesion, positive regulation of DNA-templated transcription, initiation, positive regulation of transcription, DNA-templated, branching involved in blood vessel morphogenesis, positive regulation of DNA-binding transcription factor activity, cell adhesion, negative regulation of transcription, DNA-templated, adherens junction assembly, positive regulation of transcription by RNA polymerase II, Wnt signaling pathway, calcium modulating pathway, beta-catenin-TCF complex assembly, beta-catenin destruction complex disassembly, cranial skeletal system development, proteasome-mediated ubiquitin-dependent protein catabolic process, Wnt signaling pathway, canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation, response to estradiol, midbrain dopaminergic neuron differentiation, entry of bacterium into host cell, negative regulation of oxidative stress-induced neuron death, positive regulation of core promoter binding, viral process, Wnt signaling pathway, negative regulation of angiogenesis, negative regulation of epithelial cell differentiation, adherens junction assembly, negative regulation of apoptotic process, positive regulation of molecular function, canonical Wnt signaling pathway involved in negative regulation of apoptotic process, positive regulation of transcription by RNA polymerase II, positive regulation of epithelial cell proliferation, negative regulation of neurogenesis, regulation of timing of anagen, canonical Wnt signaling pathway, regulation of canonical Wnt signaling pathway, synaptic vesicle clustering, cell-cell adhesion, neuron projection extension, positive regulation of neural precursor cell proliferation, protein polyubiquitination, tissue homeostasis, proteasome-mediated ubiquitin-dependent protein catabolic process
- Cell component
- adherens junction, beta-catenin destruction complex, protein-DNA complex, lamellipodium, beta-catenin-TCF complex, beta-catenin-TCF7L2 complex, centrosome, Z discdkac, bicellular tight junction, transcription regulator complex, lateral plasma membrane, cytoplasm, cell cortex, apical part of cell, spindle pole, Scrib-APC-beta-catenin complex, catenin-TCF7L2 complex, flotillin complex, intercalated disc, nucleus, cell-cell junction, membrane, Wnt signalosome, basolateral plasma membrane, plasma membrane, cytoskeleton, extracellular exosome, nucleoplasm, microtubule organizing center, cell periphery, apical junction complex, cell projection membrane, focal adhesion, microvillus membrane, fascia adherens, cytosol, cell junction, perinuclear region of cytoplasm, catenin complex, synapse, intracellular anatomical structure, focal adhesion, catenin complex, protein-containing complex, presynaptic membrane, cell projection, synapse, postsynaptic membrane, extracellular exosome, Schaffer collateral - CA1 synapse, presynaptic active zone cytoplasmic component, postsynaptic density, intracellular component, beta-catenin-TCF complex[21][22][23][24][25][26][27][28][29][30][31]
- Encoded by
- CTNNB1
- Found in taxon
- Homo sapiens
- Molecular function
- DNA-binding transcription factor activity, DNA binding, protein binding, SMAD binding, chromatin binding, signal transducer activity, double-stranded DNA binding, protein C-terminus binding, protein kinase binding, kinase binding, androgen receptor binding, transmembrane transporter binding, estrogen receptor binding, I-SMAD binding, protein phosphatase binding, transcription factor binding, transcription coactivator activity, alpha-catenin binding, enzyme binding, RNA polymerase II core promoter sequence-specific DNA binding, protein heterodimerization activity, cadherin binding, chromatin binding, transcription coactivator activity, protein phosphatase binding, alpha-catenin binding, cadherin binding, disordered domain specific binding[7][8][9][10][11][12][13][14][15][16][17][18][19][20]
🏷️ Also known as
en Beta-catenin
en CTNNB1 protein, human
en catenin (cadherin-associated protein), beta 1, 88kDa
en CTNNB1
en catenin beta 1
en catenin beta-1
ar بيتا-كاتينين
de Beta-Catenin
de β-Catenin
es catenina beta
fa بتا-کاتنین
fr Β-caténine
fr B-caténine
he חלבון בטא-קטנין
hu β1-katenin
it Beta catenina
it Beta-catenina
it Β-Catenina
ja Β-カテニン
ja ベータカテニン
🔖 Identifiers · 11
- OpenAlex ID
- C2779324961
- Image (Wikimedia Commons)
- 2bct murinebcat.jpg ↗
- Ensembl protein ID
- ENSP00000344456, ENSP00000379486, ENSP00000379488, ENSP00000385604, ENSP00000387455, ENSP00000400508, ENSP00000401599, ENSP00000409302, ENSP00000411226, ENSP00000412219, ENSP00000495286, ENSP00000494467, ENSP00000494914, ENSP00000495450, ENSP00000496021, ENSP00000496180, ENSP00000496649, ENSP00000493610, ENSP00000494053, ENSP00000494780, ENSP00000494422, ENSP00000496295, ENSP00000494677, ENSP00000495244, ENSP00000495161, ENSP00000495794, ENSP00000493583, ENSP00000495076, ENSP00000495426, ENSP00000495719, ENSP00000494845, ENSP00000496020, ENSP00000496511, ENSP00000493533, ENSP00000495360, ENSP00000494849, ENSP00000496584, ENSP00000494263, ENSP00000495992, ENSP00000495552, ENSP00000496385, ENSP00000495287, ENSP00000496067, ENSP00000494411, ENSP00000494654
- Exact match
- identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov
- Freebase ID
- /m/0dvr7x
- MeSH descriptor ID
- C495270
- Microsoft Academic ID (discontinued)
- 2779324961
- PDB structure ID
- 1G3J, 1JDH, 1JPW, 1LUJ, 1P22, 1QZ7, 1T08, 1TH1, 2GL7, 2Z6H, 3DIW, 3SL9, 3SLA, 3TX7, 4DJS, 3FQN, 3FQR
- RefSeq protein ID
- NP_001091679, NP_001091680, NP_001317658, NP_001895, XP_006713046, XP_006713048, XP_016861227, XP_024309124, XP_024309125, XP_024309126, XP_024309127, XP_024309128
- UMLS CUI
- C1531189
- UniProt protein ID
- P35222
🔗 Connections
Cell component 20
Biological process 14
Found in taxon 1
Has part(s) 1
Instance of 1
Molecular function 1
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