Catechol-O-methyltransferase

mammalian protein found in Homo sapiens

Protein protein Q418781

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Catechol-O-methyltransferase

Summary

Catechol-O-methyltransferase is a protein^[1].

Key Facts

Catechol-O-methyltransferase's instance of is recorded as protein^[2].
Catechol-O-methyltransferase's physically interacts with is recorded as entacapone^[3].
Catechol-O-methyltransferase's physically interacts with is recorded as tolcapone^[4].
Catechol-O-methyltransferase's physically interacts with is recorded as Viroporin 3a^[5].
Catechol-O-methyltransferase's UniProt protein ID is recorded as P21964^[6].
Catechol-O-methyltransferase's part of is recorded as catechol O-methyltransferase, eukaryotic^[7].
Catechol-O-methyltransferase's part of is recorded as S-adenosyl-L-methionine-dependent methyltransferase^[8].
Catechol-O-methyltransferase's Commons category is recorded as Catechol O-methyltransferase, COMT^[9].
Catechol-O-methyltransferase's RefSeq protein ID is recorded as NP_000745^[10].
Catechol-O-methyltransferase's RefSeq protein ID is recorded as NP_001128633^[11].
Catechol-O-methyltransferase's RefSeq protein ID is recorded as NP_001128634^[12].
Catechol-O-methyltransferase's RefSeq protein ID is recorded as NP_009294^[13].
Catechol-O-methyltransferase's RefSeq protein ID is recorded as NP_001349757^[14].
Catechol-O-methyltransferase's PDB structure ID is recorded as 4XUE^[15].
Catechol-O-methyltransferase's PDB structure ID is recorded as 3A7E^[16].
Catechol-O-methyltransferase's PDB structure ID is recorded as 3BWM^[17].
Catechol-O-methyltransferase's PDB structure ID is recorded as 3BWY^[18].
Catechol-O-methyltransferase's PDB structure ID is recorded as 4PYI^[19].
Catechol-O-methyltransferase's PDB structure ID is recorded as 4PYJ^[20].
Catechol-O-methyltransferase's PDB structure ID is recorded as 4PYK^[21].
Catechol-O-methyltransferase's PDB structure ID is recorded as 4XUC^[22].
Catechol-O-methyltransferase's PDB structure ID is recorded as 4XUD^[23].
Catechol-O-methyltransferase's Freebase ID is recorded as /m/02xg59^[24].
Catechol-O-methyltransferase's molecular function is recorded as transferase activity^[25].
Catechol-O-methyltransferase's molecular function is recorded as O-methyltransferase activity^[26].

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Quick Facts

Instance of protein

Part of catechol O-methyltransferase, eukaryotic, S-adenosyl-L-methionine-dependent methyltransferase

Properties

Biological process multicellular organismal reproductive process, negative regulation of smooth muscle cell proliferation, response to organic cyclic compound, regulation of sensory perception of pain, estrogen metabolic process, cellular response to phosphate starvation, catechol-containing compound metabolic process, female pregnancy, negative regulation of dopamine metabolic process, developmental process, learning, catecholamine metabolic process, neurotransmitter catabolic process, response to lipopolysaccharide, methylation, dopamine metabolic process, response to pain, short-term memory, negative regulation of renal sodium excretion, dopamine catabolic process, positive regulation of homocysteine metabolic process, developmental process, dopamine metabolic process, catecholamine catabolic process, response to estrogen

Cell component cytoplasm, integral component of membrane, cell body, cytosol, postsynaptic membrane, membrane, plasma membrane, dendritic spine, axon, dendrite, mitochondrion, extracellular exosome, membrane, axon, dendrite, intracellular membrane-bounded organelle, extracellular exosome

Encoded by COMT

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Imported from wholeness_audit_2026-05-02

Molecular function transferase activity, O-methyltransferase activity, metal ion binding, protein binding, magnesium ion binding, catechol O-methyltransferase activity, methyltransferase activity, L-dopa O-methyltransferase activity, orcinol O-methyltransferase activity, catechol O-methyltransferase activity

Physically interacts with entacapone, tolcapone, Viroporin 3a

External References (6)

Ensembl protein id ENSP00000416778, ENSP00000354511, ENSP00000384654, ENSP00000385150, ENSP00000385917, ENSP00000207636, ENSP00000383966, ENSP00000387695, ENSP00000403958

Freebase id /m/02xg59

Microsoft academic id (discontinued) 185361966, 2910414029

Pdb structure id 4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD

Refseq protein id NP_000745, NP_001128633, NP_001128634, NP_009294, NP_001349757

Uniprot protein id P21964

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Catechol-O-methyltransferase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Catechol-O-methyltransferase — physically interacts with (P129): entacapone. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Catechol-O-methyltransferase — physically interacts with (P129): tolcapone. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ Catechol-O-methyltransferase — physically interacts with (P129): Viroporin 3a. BioGRID. Retrieved 2020-04-19. thebiogrid.org. Provenance: wikidata.org.
[6] ↑ Catechol-O-methyltransferase — UniProt protein ID (P352): P21964. Q905695. Retrieved 2019-11-13. wikidata.org.
[7] ↑ Catechol-O-methyltransferase — part of (P361): catechol O-methyltransferase, eukaryotic. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Catechol-O-methyltransferase — part of (P361): S-adenosyl-L-methionine-dependent methyltransferase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Catechol-O-methyltransferase — Commons category (P373): Catechol O-methyltransferase, COMT. wikidata.org.
[10] ↑ Catechol-O-methyltransferase — RefSeq protein ID (P637): NP_000745. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ Catechol-O-methyltransferase — RefSeq protein ID (P637): NP_001128633. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ Catechol-O-methyltransferase — RefSeq protein ID (P637): NP_001128634. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ Catechol-O-methyltransferase — RefSeq protein ID (P637): NP_009294. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Catechol-O-methyltransferase — RefSeq protein ID (P637): NP_001349757. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ Catechol-O-methyltransferase — PDB structure ID (P638): 4XUE. Q905695. Retrieved 2016-08-09. wikidata.org.
[16] ↑ Catechol-O-methyltransferase — PDB structure ID (P638): 3A7E. Q905695. Retrieved 2016-08-09. wikidata.org.
[17] ↑ Catechol-O-methyltransferase — PDB structure ID (P638): 3BWM. Q905695. Retrieved 2016-08-09. wikidata.org.
[18] ↑ Catechol-O-methyltransferase — PDB structure ID (P638): 3BWY. Q905695. Retrieved 2016-08-09. wikidata.org.
[19] ↑ Catechol-O-methyltransferase — PDB structure ID (P638): 4PYI. Q905695. Retrieved 2016-08-09. wikidata.org.
[20] ↑ Catechol-O-methyltransferase — PDB structure ID (P638): 4PYJ. Q905695. Retrieved 2016-08-09. wikidata.org.
[21] ↑ Catechol-O-methyltransferase — PDB structure ID (P638): 4PYK. Q905695. Retrieved 2016-08-09. wikidata.org.
[22] ↑ Catechol-O-methyltransferase — PDB structure ID (P638): 4XUC. Q905695. Retrieved 2016-08-09. wikidata.org.
[23] ↑ Catechol-O-methyltransferase — PDB structure ID (P638): 4XUD. Q905695. Retrieved 2016-08-09. wikidata.org.
[24] ↑ Catechol-O-methyltransferase — Freebase ID (P646): /m/02xg59. Freebase Data Dumps. wikidata.org.
[25] ↑ Catechol-O-methyltransferase — molecular function (P680): transferase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Catechol-O-methyltransferase — molecular function (P680): O-methyltransferase activity. Cloning and Characterization of Human Placental Catechol--Methyltransferase cDNA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Catechol-O-methyltransferase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Catechol-O-methyltransferase. Retrieved May 3, 2026, from https://4ort.xyz/entity/catechol-o-methyltransferase-q418781

MLA

“Catechol-O-methyltransferase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/catechol-o-methyltransferase-q418781.

BibTeX

@misc{4ortxyz_catechol-o-methyltransferase-q418781_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Catechol-O-methyltransferase}}, year = {2026}, url = {https://4ort.xyz/entity/catechol-o-methyltransferase-q418781}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Catechol-O-methyltransferase — https://4ort.xyz/entity/catechol-o-methyltransferase-q418781 (retrieved 2026-05-03)

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