catechol-O-methyltransferase

mammalian protein found in Mus musculus

Protein protein Q14863661

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catechol-O-methyltransferase

Summary

catechol-O-methyltransferase is a protein^[1].

Key Facts

catechol-O-methyltransferase's instance of is recorded as protein^[2].
catechol-O-methyltransferase's subclass of is recorded as protein^[3].
catechol-O-methyltransferase's UniProt protein ID is recorded as O88587^[4].
catechol-O-methyltransferase's part of is recorded as catechol O-methyltransferase, eukaryotic^[5].
catechol-O-methyltransferase's part of is recorded as S-adenosyl-L-methionine-dependent methyltransferase^[6].
catechol-O-methyltransferase's part of is recorded as membrane protein^[7].
catechol-O-methyltransferase's RefSeq protein ID is recorded as NP_001104532^[8].
catechol-O-methyltransferase's RefSeq protein ID is recorded as NP_001104533^[9].
catechol-O-methyltransferase's RefSeq protein ID is recorded as NP_031770^[10].
catechol-O-methyltransferase's RefSeq protein ID is recorded as XP_036015657^[11].
catechol-O-methyltransferase's PDB structure ID is recorded as 4P58^[12].
catechol-O-methyltransferase's PDB structure ID is recorded as 4P7F^[13].
catechol-O-methyltransferase's molecular function is recorded as methyltransferase activity^[14].
catechol-O-methyltransferase's molecular function is recorded as transferase activity^[15].
catechol-O-methyltransferase's molecular function is recorded as O-methyltransferase activity^[16].
catechol-O-methyltransferase's molecular function is recorded as metal ion binding^[17].
catechol-O-methyltransferase's molecular function is recorded as magnesium ion binding^[18].
catechol-O-methyltransferase's molecular function is recorded as L-dopa O-methyltransferase activity^[19].
catechol-O-methyltransferase's molecular function is recorded as orcinol O-methyltransferase activity^[20].
catechol-O-methyltransferase's molecular function is recorded as catechol O-methyltransferase activity^[21].
catechol-O-methyltransferase's molecular function is recorded as catechol O-methyltransferase activity^[22].
catechol-O-methyltransferase's cell component is recorded as cytoplasm^[23].
catechol-O-methyltransferase's cell component is recorded as integral component of membrane^[24].
catechol-O-methyltransferase's cell component is recorded as mitochondrion^[25].
catechol-O-methyltransferase's cell component is recorded as axon^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Subclass of protein

Part of catechol O-methyltransferase, eukaryotic, S-adenosyl-L-methionine-dependent methyltransferase, membrane protein

Properties

Biological process response to organic cyclic compound, cellular response to phosphate starvation, catechol-containing compound metabolic process, catecholamine metabolic process, neurotransmitter catabolic process, response to lipopolysaccharide, methylation, dopamine metabolic process, dopamine catabolic process, female pregnancy, short-term memory, regulation of sensory perception of pain, negative regulation of renal sodium excretion, learning, negative regulation of dopamine metabolic process, multicellular organismal reproductive process, response to pain, negative regulation of smooth muscle cell proliferation, positive regulation of homocysteine metabolic process, estrogen metabolic process, developmental process, response to estrogen, catecholamine catabolic process, female pregnancy, learning, short-term memory, estrogen metabolic process, developmental process, negative regulation of renal sodium excretion, dopamine metabolic process, catecholamine catabolic process, negative regulation of dopamine metabolic process, response to pain, multicellular organismal reproductive process, negative regulation of smooth muscle cell proliferation, positive regulation of homocysteine metabolic process, regulation of sensory perception of pain

Cell component cytoplasm, integral component of membrane, mitochondrion, axon, plasma membrane, dendrite, dendritic spine, postsynaptic membrane, cell body, cytosol, membrane, intracellular membrane-bounded organelle, mitochondrion, cytosol, membrane, axon, dendrite, dendritic spine, cell body, postsynaptic membrane

Encoded by Comt

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon house mouse

Imported from wholeness_audit_2026-05-02

Molecular function methyltransferase activity, transferase activity, O-methyltransferase activity, metal ion binding, magnesium ion binding, L-dopa O-methyltransferase activity, orcinol O-methyltransferase activity, catechol O-methyltransferase activity, catechol O-methyltransferase activity

External References (4)

Ensembl protein id ENSMUSP00000000335, ENSMUSP00000111272, ENSMUSP00000130077, ENSMUSP00000121810

Pdb structure id 4P58, 4P7F

Refseq protein id NP_001104532, NP_001104533, NP_031770, XP_036015657

Uniprot protein id O88587

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ catechol-O-methyltransferase — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ catechol-O-methyltransferase — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ catechol-O-methyltransferase — UniProt protein ID (P352): O88587. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ catechol-O-methyltransferase — part of (P361): catechol O-methyltransferase, eukaryotic. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ catechol-O-methyltransferase — part of (P361): S-adenosyl-L-methionine-dependent methyltransferase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ catechol-O-methyltransferase — part of (P361): membrane protein. wikidata.org.
[8] ↑ catechol-O-methyltransferase — RefSeq protein ID (P637): NP_001104532. Q20641742. Retrieved 2022-03-20. wikidata.org.
[9] ↑ catechol-O-methyltransferase — RefSeq protein ID (P637): NP_001104533. Q20641742. Retrieved 2022-03-20. wikidata.org.
[10] ↑ catechol-O-methyltransferase — RefSeq protein ID (P637): NP_031770. Q20641742. Retrieved 2022-03-20. wikidata.org.
[11] ↑ catechol-O-methyltransferase — RefSeq protein ID (P637): XP_036015657. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ catechol-O-methyltransferase — PDB structure ID (P638): 4P58. Q905695. Retrieved 2016-08-09. wikidata.org.
[13] ↑ catechol-O-methyltransferase — PDB structure ID (P638): 4P7F. Q905695. Retrieved 2016-08-09. wikidata.org.
[14] ↑ catechol-O-methyltransferase — molecular function (P680): methyltransferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ catechol-O-methyltransferase — molecular function (P680): transferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ catechol-O-methyltransferase — molecular function (P680): O-methyltransferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ catechol-O-methyltransferase — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ catechol-O-methyltransferase — molecular function (P680): magnesium ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ catechol-O-methyltransferase — molecular function (P680): L-dopa O-methyltransferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ catechol-O-methyltransferase — molecular function (P680): orcinol O-methyltransferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ catechol-O-methyltransferase — molecular function (P680): catechol O-methyltransferase activity. GOA. Retrieved 2018-01-31. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ catechol-O-methyltransferase — molecular function (P680): catechol O-methyltransferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ catechol-O-methyltransferase — cell component (P681): cytoplasm. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ catechol-O-methyltransferase — cell component (P681): integral component of membrane. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ catechol-O-methyltransferase — cell component (P681): mitochondrion. A mitochondrial protein compendium elucidates complex I disease biology. Retrieved 2018-01-31. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ catechol-O-methyltransferase — cell component (P681): axon. GOA. Retrieved 2018-01-31. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ catechol-O-methyltransferase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). catechol-O-methyltransferase. Retrieved May 3, 2026, from https://4ort.xyz/entity/catechol-o-methyltransferase-q14863661

MLA

“catechol-O-methyltransferase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/catechol-o-methyltransferase-q14863661.

BibTeX

@misc{4ortxyz_catechol-o-methyltransferase-q14863661_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{catechol-O-methyltransferase}}, year = {2026}, url = {https://4ort.xyz/entity/catechol-o-methyltransferase-q14863661}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): catechol-O-methyltransferase — https://4ort.xyz/entity/catechol-o-methyltransferase-q14863661 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/catechol-o-methyltransferase-q14863661 · Last refreshed: May 3, 2026