Caspase 3

mammalian protein found in Homo sapiens

Protein protein Q5049057

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Caspase 3

Summary

Caspase 3 is a protein^[1].

Key Facts

Caspase 3's instance of is recorded as protein^[2].
Caspase 3's physically interacts with is recorded as emricasan^[3].

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Quick Facts

Instance of protein

Properties

Biological process cellular response to organic substance, neuron apoptotic process, cell fate commitment, response to estradiol, intracellular signal transduction, response to hypoxia, response to amino acid, apoptotic DNA fragmentation, response to organic cyclic compound, negative regulation of cyclin-dependent protein serine/threonine kinase activity, response to antibiotic, platelet formation, protein processing, response to nicotine, response to metal ion, negative regulation of cell cycle, wound healing, response to glucocorticoid, cellular response to organic cyclic compound, B cell homeostasis, negative regulation of apoptotic process, hearing, response to glucose, response to organic substance, hippo signaling, glial cell apoptotic process, keratinocyte differentiation, proteolysis, cellular response to DNA damage stimulus, T cell homeostasis, response to tumor necrosis factor, negative regulation of activated T cell proliferation, development of the heart, response to lipopolysaccharide, positive regulation of neuron apoptotic process, response to wounding, neuron differentiation, extrinsic apoptotic signaling pathway in absence of ligand, learning or memory, positive regulation of apoptotic process, erythrocyte differentiation, apoptotic signaling pathway, negative regulation of B cell proliferation, response to cobalt ion, hippocampus development, response to UV, response to X-ray, response to hydrogen peroxide, regulation of macroautophagy, neurotrophin TRK receptor signaling pathway, execution phase of apoptosis, intrinsic apoptotic signaling pathway in response to osmotic stress, cellular response to staurosporine, apoptotic process, cytokine-mediated signaling pathway, activation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of catalytic activity, luteolysis, apoptotic process, axonal fasciculation, erythrocyte differentiation, striated muscle cell differentiation, leukocyte apoptotic process, regulation of protein stability, positive regulation of amyloid-beta formation, anterior neural tube closure

Cell component cytoplasm, cytosol, nucleoplasm, death-inducing signaling complex, membrane raft, nucleus, cytoplasm, soma

Ec enzyme number 3.4.22.56

Encoded by CASP3

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Molecular function cysteine-type peptidase activity, peptidase activity, protein binding, phospholipase A2 activator activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type endopeptidase activity, hydrolase activity, cysteine-type endopeptidase activator activity involved in apoptotic process, aspartic-type endopeptidase activity, protease binding, death receptor binding, protein-containing complex binding, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, cysteine-type endopeptidase activity involved in apoptotic process, aspartic-type endopeptidase activity

Physically interacts with emricasan

External References (6)

Ensembl protein id ENSP00000428372, ENSP00000407142, ENSP00000311032, ENSP00000377210, ENSP00000377213, ENSP00000428929

Mesh descriptor id D053148

Mesh tree code D08.811.277.656.262.500.126.350.300, D08.811.277.656.300.200.126.350.300, D12.776.476.075.405.350.300

Pdb structure id 1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M, 2C2O, 2CDR, 2CJX, 2CJY, 2CNK, 2CNL, 2CNN, 2CNO, 2DKO, 2H5I, 2H5J, 2H65, 2J30, 2J31, 2J32, 2J33, 2XYG, 2XYH, 2XYP, 2XZD, 2XZT, 2Y0B, 3DEH, 3DEI, 3DEJ, 3DEK, 3EDQ, 3GJQ, 3GJR, 3GJS, 3GJT, 3H0E, 3ITN, 3KJF, 3PCX, 3PD0, 3PD1, 4DCJ, 4DCO, 4DCP, 4EHA, 4EHD, 4EHF, 4EHH, 4EHK, 4EHL, 4EHN, 4JJE, 4JQY, 4JQZ, 4JR0, 4PRY, 4PS0, 4QTX, 4QTY, 4QU0, 4QU5, 4QU8, 4QU9, 4QUA, 4QUB, 4QUD, 4QUE, 4QUG, 4QUH, 4QUI, 4QUJ, 4QUL, 5IC4

Refseq protein id NP_004337, NP_116786, NP_001341706, NP_001341708, NP_001341709, NP_001341710, NP_001341711, NP_001341712, NP_001341713

Uniprot protein id P42574

🏷️ Also known as

en apopain en CASP-3 en CASP3 en caspase-3 en Caspase 3 en caspase 3, apoptosis-related cysteine peptidase en caspase 3, apoptosis-related cysteine protease en CPP-32 en cysteine protease CPP32 en PARP cleavage protease en protein Yama en SCA-1 en SREBP cleavage activity 1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Caspase 3 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Caspase 3 — physically interacts with (P129): emricasan. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.

Class ancestry

[1] ↑ Caspase 3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Caspase 3. Retrieved May 3, 2026, from https://4ort.xyz/entity/caspase-3

MLA “Caspase 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/caspase-3.

BibTeX

@misc{4ortxyz_caspase-3_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Caspase 3}}, year = {2026}, url = {https://4ort.xyz/entity/caspase-3}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Caspase 3 — https://4ort.xyz/entity/caspase-3 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/caspase-3 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

5w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Physically interacts with → emricasan

Uniprot protein id → P42574

Ec enzyme number → 3.4.22.56

Refseq protein id → NP_004337, NP_116786, NP_001341706 +6

+ 13 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 3.4.22.56, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"

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