Q: What is C8 Silica Gel used for?

A: C8 Silica Gel is primarily used as a stationary phase in reversed-phase liquid chromatography (e.g., HPLC) to separate hydrophobic and moderately polar compounds. It is less retentive than C18 silica, making it ideal for analytes that require intermediate polarity interactions, such as small organic molecules, peptides, and pharmaceuticals.

Q: How does C8 Silica Gel differ from C18 Silica Gel?

A: C8 Silica Gel has an octyl (8-carbon) functional group bonded to its surface, while C18 Silica Gel has an octadecyl (18-carbon) chain. This difference makes C8 less hydrophobic and less retentive, suitable for separating compounds that are too strongly retained on C18 phases. C8 is often preferred for moderately polar analytes or when shorter analysis times are desired.

Q: What types of compounds can be separated using C8 Silica Gel?

A: C8 Silica Gel effectively separates hydrophobic and semi-polar compounds, including: - Small organic molecules (e.g., drugs, pesticides). - Peptides and small proteins. - Lipids and fatty acids. - Environmental contaminants (e.g., polycyclic aromatic hydrocarbons). Its selectivity is tailored for analytes that interact weakly with highly non-polar phases like C18.

Q: Is C8 Silica Gel hazardous?

A: While C8 Silica Gel itself is chemically inert and non-volatile (vapor pressure 0 mm Hg), it shares the inhalation hazards of its parent material, silica gel. Fine particles can pose respiratory risks, and NIOSH sets a Time-Weighted Average (TWA) exposure limit of 6 mg/m³ and an Immediately Dangerous to Life or Health (IDLH) limit of 3,000 mg/m³.

Q: How is C8 Silica Gel prepared?

A: The source material does not detail the synthesis, but modified silica gels like C8 are typically prepared by reacting silica gel with organosilanes (e.g., octyltrichlorosilane) under controlled conditions. This bonds the octyl chains to the silica surface via siloxane linkages, creating a hydrophobic stationary phase.

Q: Can C8 Silica Gel be used with aqueous mobile phases?

A: Yes, C8 Silica Gel is designed for reversed-phase chromatography, which commonly uses polar mobile phases like water-methanol or water-acetonitrile mixtures. Its hydrophobic surface interacts with non-polar analytes, enabling their separation from the polar solvent.

Q: What are the advantages of C8 Silica Gel over other stationary phases?

A: Advantages include: - **Intermediate selectivity:** Less retentive than C18 but more selective for moderately polar compounds. - **Faster separations:** Reduced retention times compared to C18 for certain analytes. - **Versatility:** Compatible with a wide range of mobile phases and sample types. - **Stability:** Chemically bonded phase resists hydrolysis and degradation under typical HPLC conditions.

Q: How does C8 Silica Gel compare to other modified silica gels (e.g., Cyano, Amino)?

A: C8 Silica Gel is **non-polar**, making it suitable for reversed-phase chromatography, while **Cyano** and **Amino** silica gels are polar or ion-exchange phases. Cyano phases are moderately polar and can be used in both normal and reversed-phase modes, while Amino phases are strongly polar or anionic, often used for carbohydrate or nucleic acid separations. C8’s octyl chain provides a balance of hydrophobicity not found in these alternatives.

C8 Silica Gel

modified silica gel used in chromatography

class chemical_substance Q115221229

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C8 Silica Gel

Summary

C8 Silica Gel is a chemical substance^[1]. It is known by 5 alternative names across languages and contexts.^[2]

Key Facts

C8 Silica Gel's instance of is recorded as chemical substance^[3].
C8 Silica Gel's subclass of is recorded as column packing material^[4].
C8 Silica Gel's subclass of is recorded as silica gel^[5].

Why It Matters

C8 Silica Gel is known by 5 alternative names across languages and contexts.^[2]

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Instance of chemical substance

Subclass of column packing material, silica gel

🏷️ Also known as

en C8-bonded Silica Gel en C8-modified Silica Gel en Octyl-functionalized silica gel en Octyl silica en Si-C8

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Instance of 1

chemical substance

Subclass of 1

silica gel

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[1] ↑ C8 Silica Gel is an instance of chemical substance (Q79529) [P31, primary]. Wikidata. wikidata.org.

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[2] ↑ C8 Silica Gel is known by 5 alternative names across languages and contexts.. Wikidata aliases. wikidata.org.

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C8 Silica Gel

C8 Silica Gel

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