C-abl oncogene 1, non-receptor tyrosine kinase

mammalian protein found in Mus musculus

Protein protein Q14874000

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C-abl oncogene 1, non-receptor tyrosine kinase

Summary

C-abl oncogene 1, non-receptor tyrosine kinase is a protein^[1].

Key Facts

C-abl oncogene 1, non-receptor tyrosine kinase's instance of is recorded as protein^[2].
C-abl oncogene 1, non-receptor tyrosine kinase's subclass of is recorded as protein^[3].
C-abl oncogene 1, non-receptor tyrosine kinase's UniProt protein ID is recorded as P00520^[4].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as Tyrosine-protein kinase ABL1/transforming protein Abl^[5].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as Protein kinase-like domain superfamily^[6].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as SH3-like domain superfamily^[7].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as SH2 domain superfamily^[8].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as F-actin binding domain, protein family^[9].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[10].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as SH2 domain, protein family^[11].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as Tyrosine-protein kinase ABL, SH2 domain, protein family^[12].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as SH3 domain, protein family^[13].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as Protein kinase domain, protein family^[14].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as Protein kinase, ATP binding site, protein family^[15].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as Tyrosine-protein kinase, catalytic domain, protein family^[16].
C-abl oncogene 1, non-receptor tyrosine kinase's part of is recorded as Tyrosine-protein kinase, active site, protein family^[17].
C-abl oncogene 1, non-receptor tyrosine kinase's has part is recorded as SH2 domain^[18].
C-abl oncogene 1, non-receptor tyrosine kinase's has part is recorded as tyrosine-protein kinase, catalytic domain^[19].
C-abl oncogene 1, non-receptor tyrosine kinase's has part is recorded as tyrosine-protein kinase, active site^[20].
C-abl oncogene 1, non-receptor tyrosine kinase's has part is recorded as F-actin binding^[21].
C-abl oncogene 1, non-receptor tyrosine kinase's has part is recorded as serine-threonine/tyrosine-protein kinase, catalytic domain^[22].
C-abl oncogene 1, non-receptor tyrosine kinase's has part is recorded as SH3 domain^[23].
C-abl oncogene 1, non-receptor tyrosine kinase's has part is recorded as protein kinase, ATP binding site^[24].
C-abl oncogene 1, non-receptor tyrosine kinase's has part is recorded as protein kinase domain^[25].
C-abl oncogene 1, non-receptor tyrosine kinase's has part is recorded as Tyrosine-protein kinase ABL, SH2 domain^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Tyrosine-protein kinase ABL1/transforming protein Abl, Protein kinase-like domain superfamily, SH3-like domain superfamily, SH2 domain superfamily, F-actin binding domain, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, SH2 domain, protein family, Tyrosine-protein kinase ABL, SH2 domain, protein family, SH3 domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process positive regulation of protein phosphorylation, B-1 B cell homeostasis, regulation of axon extension, neuromuscular process controlling balance, cellular response to DNA damage stimulus, protein phosphorylation, regulation of microtubule polymerization, DNA damage induced protein phosphorylation, positive regulation of ERK1 and ERK2 cascade, substrate adhesion-dependent cell spreading, platelet-derived growth factor receptor-beta signaling pathway, apoptotic process, B cell receptor signaling pathway, positive regulation of actin filament binding, negative regulation of endothelial cell apoptotic process, cerebellum morphogenesis, epidermal growth factor receptor signaling pathway, establishment of protein localization, thymus development, negative regulation of phospholipase C activity, positive regulation of mitotic cell cycle, actin filament branching, spleen development, response to oxidative stress, phagocytosis, positive regulation of peptidyl-tyrosine phosphorylation, regulation of response to DNA damage stimulus, platelet-derived growth factor receptor signaling pathway, positive regulation of Wnt signaling pathway, planar cell polarity pathway, innate immune response, DNA repair, regulation of actin cytoskeleton organization, phosphorylation, positive regulation of oxidoreductase activity, positive regulation of release of sequestered calcium ion into cytosol, negative regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of microtubule binding, cell adhesion, peptidyl-tyrosine autophosphorylation, alpha-beta T cell differentiation, regulation of cellular senescence, negative regulation of protein serine/threonine kinase activity, negative regulation of cellular senescence, positive regulation of osteoblast proliferation, endocytosis, activated T cell proliferation, negative regulation of cell-cell adhesion, B cell proliferation involved in immune response, positive regulation of cytosolic calcium ion concentration, regulation of cell cycle, negative regulation of BMP signaling pathway, autophagy, B cell proliferation, negative regulation of ubiquitin-protein transferase activity, microspike assembly, positive regulation of apoptotic process, regulation of extracellular matrix organization, positive regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of ERK1 and ERK2 cascade, transitional one stage B cell differentiation, Bergmann glial cell differentiation, peptidyl-tyrosine phosphorylation, collateral sprouting, cellular response to lipopolysaccharide, negative regulation of mitotic cell cycle, protein autophosphorylation, blood coagulation, activation of protein kinase C activity, cellular response to hydrogen peroxide, positive regulation of muscle cell differentiation, neural tube closure, post-embryonic development, actin cytoskeleton organization, neuron differentiation, regulation of cell population proliferation, signal transduction in response to DNA damage, neuroepithelial cell differentiation, positive regulation of neuron death, protein phosphorylation, integrin-mediated signaling pathway, positive regulation of endothelial cell migration, cell differentiation, regulation of Cdc42 protein signal transduction, neuropilin signaling pathway, regulation of cell population proliferation, endothelial cell migration, regulation of T cell differentiation, T cell receptor signaling pathway, positive regulation of stress fiber assembly, positive regulation of focal adhesion assembly, DNA conformation change, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of substrate adhesion-dependent cell spreading, negative regulation of long-term synaptic potentiation, regulation of modification of synaptic structure, positive regulation of blood vessel branching, positive regulation of actin cytoskeleton reorganization, DNA conformation change, actin cytoskeleton organization

Cell component cytosol, extrinsic component of cytoplasmic side of plasma membrane, actin cytoskeleton, perinuclear region of cytoplasm, cytoskeleton, nucleus, nucleolus, nucleoplasm, cell leading edge, mitochondrion, neuron projection, nuclear body, cytoplasm, ruffle, mitochondrion, endoplasmic reticulum, dendrite, growth cone, protein-containing complex, soma, synapse

Encoded by Abl1

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon house mouse

Has part(s) SH2 domain, tyrosine-protein kinase, catalytic domain, tyrosine-protein kinase, active site, F-actin binding, serine-threonine/tyrosine-protein kinase, catalytic domain, SH3 domain, protein kinase, ATP binding site, protein kinase domain, Tyrosine-protein kinase ABL, SH2 domain

Imported from wholeness_audit_2026-05-02

Molecular function protein domain specific binding, SH3 domain binding, kinase activity, protein C-terminus binding, signaling receptor binding, ATP binding, protein kinase activity, non-membrane spanning protein tyrosine kinase activity, metal ion binding, proline-rich region binding, magnesium ion binding, transferase activity, actin filament binding, protein binding, protein tyrosine kinase activity, syntaxin binding, nucleotide binding, DNA binding, manganese ion binding, mitogen-activated protein kinase binding, protein kinase C binding, phosphotyrosine residue binding, SH2 domain binding, four-way junction DNA binding, bubble DNA binding, protein kinase activity, kinase activity, protein kinase binding, neuropilin binding, ephrin receptor binding, delta-catenin binding, sequence-specific double-stranded DNA binding, four-way junction DNA binding, bubble DNA binding, sequence-specific double-stranded DNA binding

External References (4)

Ensembl protein id ENSMUSP00000028190, ENSMUSP00000075167, ENSMUSP00000117748, ENSMUSP00000141320, ENSMUSP00000142123, ENSMUSP00000142297

Pdb structure id 1ABO, 1ABQ, 1FPU, 1IEP, 1M52, 1OPJ, 1OPK, 2HZN, 2QOH, 2Z60, 3DK3, 3DK6, 3DK7, 3K5V, 3MS9, 3MSS, 3IK3, 3KF4, 3KFA, 3OXZ, 3OY3, 5IH2

Refseq protein id NP_001106174, NP_001269974, NP_001269975, NP_001269976, NP_033724, XP_006497684

Uniprot protein id P00520

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — UniProt protein ID (P352): P00520. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): Tyrosine-protein kinase ABL1/transforming protein Abl. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): SH3-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): F-actin binding domain, protein family. wikidata.org.
[10] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[11] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): SH2 domain, protein family. wikidata.org.
[12] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): Tyrosine-protein kinase ABL, SH2 domain, protein family. wikidata.org.
[13] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): SH3 domain, protein family. wikidata.org.
[14] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): Protein kinase domain, protein family. wikidata.org.
[15] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[16] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[17] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[18] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — has part(s) (P527): F-actin binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — has part(s) (P527): SH3 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ C-abl oncogene 1, non-receptor tyrosine kinase — has part(s) (P527): Tyrosine-protein kinase ABL, SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ C-abl oncogene 1, non-receptor tyrosine kinase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“C-abl oncogene 1, non-receptor tyrosine kinase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/c-abl-oncogene-1-non-receptor-tyrosine-kinase.

BibTeX

@misc{4ortxyz_c-abl-oncogene-1-non-receptor-tyrosine-kinase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{C-abl oncogene 1, non-receptor tyrosine kinase}}, year = {2026}, url = {https://4ort.xyz/entity/c-abl-oncogene-1-non-receptor-tyrosine-kinase}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): C-abl oncogene 1, non-receptor tyrosine kinase — https://4ort.xyz/entity/c-abl-oncogene-1-non-receptor-tyrosine-kinase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/c-abl-oncogene-1-non-receptor-tyrosine-kinase · Last refreshed: May 3, 2026