Quick Facts
Part of
BRCT domain superfamily, Breast cancer type 1 susceptibility protein (BRCA1), Zinc finger, RING/FYVE/PHD-type, BRCA1, serine-rich domain, protein family, Zinc finger, RING-type, protein family, Zinc finger, C3HC4 RING-type, protein family, BRCT domain, protein family, Zinc finger, RING-type, conserved site, protein family
Properties
Biological process
response to ionizing radiation, centrosome cycle, chromosome segregation, protein K6-linked ubiquitination, intrinsic apoptotic signaling pathway in response to DNA damage, cell cycle, double-strand break repair via nonhomologous end joining, apoptotic process, regulation of apoptotic process, regulation of gene expression by genetic imprinting, regulation of transcription, DNA-templated, negative regulation of fatty acid biosynthetic process, transcription, DNA-templated, regulation of transcription by RNA polymerase III, fatty acid biosynthetic process, regulation of DNA methylation, negative regulation of intracellular estrogen receptor signaling pathway, protein autoubiquitination, positive regulation of histone H3-K9 methylation, DNA recombination, positive regulation of angiogenesis, response to estrogen, cellular response to indole-3-methanol, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of transcription, DNA-templated, positive regulation of protein ubiquitination, androgen receptor signaling pathway, negative regulation of centriole replication, postreplication repair, lipid metabolism, cellular response to tumor necrosis factor, positive regulation of DNA repair, fatty acid metabolic process, positive regulation of gene expression, negative regulation of histone H3-K4 methylation, regulation of cell population proliferation, negative regulation of reactive oxygen species metabolic process, positive regulation of vascular endothelial growth factor production, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, positive regulation of transcription by RNA polymerase II, positive regulation of histone H4-K20 methylation, DNA double-strand break processing, double-strand break repair via homologous recombination, negative regulation of histone acetylation, protein ubiquitination, positive regulation of histone H3-K4 methylation, DNA repair, double-strand break repair, positive regulation of histone acetylation, dosage compensation by inactivation of X chromosome, negative regulation of histone H3-K9 methylation, positive regulation of histone H3-K9 acetylation, positive regulation of transcription, DNA-templated, chordate embryonic development, positive regulation of histone H4-K16 acetylation, cellular response to DNA damage stimulus, protein deubiquitination, DNA replication, mitotic G2/M transition checkpoint, regulation of transcription by RNA polymerase II, negative regulation of G0 to G1 transition, transcription by RNA polymerase II, mitotic G2 DNA damage checkpoint signaling, double-strand break repair via homologous recombination, positive regulation of histone acetylation, negative regulation of fatty acid biosynthetic process, positive regulation of transcription by RNA polymerase II, regulation of signal transduction by p53 class mediator
Cell component
BRCA1-BARD1 complex, condensed nuclear chromosome, BRCA1-A complex, ubiquitin ligase complex, plasma membrane, nucleoplasm, condensed chromosome, cytoplasm, chromosome, nucleus, lateral element, protein-containing complex, ribonucleoprotein complex, plasma membrane, BRCA1-BARD1 complex, BRCA1-A complex
Molecular function
tubulin binding, metal ion binding, enzyme binding, zinc ion binding, damaged DNA binding, protein binding, transcription coactivator activity, androgen receptor binding, RNA binding, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, DNA binding, transferase activity, transcription coactivator activity, RNA polymerase binding, transcription coactivator activity, identical protein binding, ubiquitin-protein transferase activity
Part of
BRCT domain superfamily, Breast cancer type 1 susceptibility protein (BRCA1), Zinc finger, RING/FYVE/PHD-type, BRCA1, serine-rich domain, protein family, Zinc finger, RING-type, protein family, Zinc finger, C3HC4 RING-type, protein family, BRCT domain, protein family, Zinc finger, RING-type, conserved site, protein family
External References (9)
Ensembl protein id
ENSP00000312236, ENSP00000350283, ENSP00000417148, ENSP00000417988, ENSP00000418548, ENSP00000418775, ENSP00000418960, ENSP00000420705, ENSP00000326002, ENSP00000397145, ENSP00000417241, ENSP00000417554, ENSP00000418212, ENSP00000418819, ENSP00000418986, ENSP00000419103, ENSP00000419274, ENSP00000419481, ENSP00000419988, ENSP00000420201, ENSP00000420253, ENSP00000420412, ENSP00000420781, ENSP00000465347, ENSP00000465818, ENSP00000467329, ENSP00000478114, ENSP00000489431, ENSP00000494614, ENSP00000495897, ENSP00000496570, ENSP00000498906
Freebase id
/m/0256r1
Mesh descriptor id
D019313
Mesh tree code
D12.776.313.125, D12.776.624.776.100, D12.776.660.100, D12.776.744.100, D12.776.930.137
Omim id
113705
Pdb structure id
1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD, 3PXE, 4IFI, 4IGK, 4JLU, 4OFB, 4U4A, 4Y18, 4Y2G
Refseq protein id
NP_009225, NP_009228, NP_009229, NP_009230, NP_009231
Umls cui
C0259275
Uniprot protein id
P38398