Beta-2-microglobulin

mammalian protein found in Homo sapiens

Protein protein Q287896

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Summary

Beta-2-microglobulin is a protein^[1]. Beta-2-microglobulin ranks in the top 9% of protein entities by monthly Wikipedia readership (154 views/month).^[2]

Key Facts

Beta-2-microglobulin's instance of is recorded as protein^[3].
Beta-2-microglobulin is part of Immunoglobulin-like fold^[4].
Beta-2-microglobulin is part of Immunoglobulin-like domain superfamily^[5].
Beta-2-microglobulin is part of beta-2-microglobulin^[6].
Beta-2-microglobulin is part of Immunoglobulin C1-set, protein family^[7].
Beta-2-microglobulin is part of immunoglobulin-like domain, protein family^[8].
Beta-2-microglobulin is part of Immunoglobulin/major histocompatibility complex, conserved site, protein family^[9].
Beta-2-microglobulin comprises immunoglobulin C1-set^[10].
Beta-2-microglobulin comprises immunoglobulin-like domain^[11].
Beta-2-microglobulin comprises Immunoglobulin/major histocompatibility complex, conserved site^[12].

Why It Matters

Beta-2-microglobulin ranks in the top 9% of protein entities by monthly Wikipedia readership (154 views/month).^[2] Beta-2-microglobulin has Wikipedia articles in 13 language editions, a strong signal of global cultural recognition.^[13] Beta-2-microglobulin is known by 23 alternative names across languages and contexts.^[14]

⭐ Popularity Graph

21/100 established

🌐 Wiki Languages

18 / 427 langs

📈 Wikipedia Views · last 243h

723/mo 2.8K/yr

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MHC class I

Quick Facts

Instance of protein

Part of Immunoglobulin-like fold, Immunoglobulin-like domain superfamily, beta-2-microglobulin, Immunoglobulin C1-set, protein family, immunoglobulin-like domain, protein family, Immunoglobulin/major histocompatibility complex, conserved site, protein family

Properties

Biological process positive regulation of receptor-mediated endocytosis, cellular response to iron ion, response to cadmium ion, negative regulation of receptor binding, negative regulation of neuron projection development, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, T cell differentiation in thymus, immune system process, interferon-gamma-mediated signaling pathway, antigen processing and presentation of peptide antigen via MHC class I, iron ion homeostasis, positive regulation of T cell mediated cytotoxicity, mitigation of host defenses by virus, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent, regulation of membrane depolarization, antigen processing and presentation of endogenous peptide antigen via MHC class I, positive regulation of ferrous iron binding, positive regulation of transferrin receptor binding, retina homeostasis, positive regulation of T cell cytokine production, protein refolding, immune response, regulation of immune response, positive regulation of receptor binding, positive regulation of protein binding, innate immune response, cellular response to lipopolysaccharide, response to molecule of bacterial origin, antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent, iron ion transport, neutrophil degranulation, regulation of erythrocyte differentiation, cellular response to iron(III) ion, antimicrobial humoral immune response mediated by antimicrobial peptide, positive regulation of iron ion import across plasma membrane, retina homeostasis, regulation of iron ion transport, innate immune response

Cell component HFE-transferrin receptor complex, Golgi apparatus, phagocytic vesicle membrane, early endosome membrane, endoplasmic reticulum lumen, membrane, focal adhesion, Golgi membrane, plasma membrane, extracellular region, MHC class I protein complex, ER to Golgi transport vesicle membrane, early endosome lumen, extracellular exosome, external side of plasma membrane, extracellular space, cytosol, cell surface, specific granule lumen, recycling endosome membrane, tertiary granule lumen, extracellular space, focal adhesion, membrane, extracellular exosome, MHC class I peptide loading complex

Encoded by B2M

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Has part(s) immunoglobulin C1-set, immunoglobulin-like domain, Immunoglobulin/major histocompatibility complex, conserved site

Molecular function protein binding, identical protein binding

External References (10)

Cas registry number 138662-97-2

Ensembl protein id ENSP00000453191, ENSP00000453350, ENSP00000481426, ENSP00000488321, ENSP00000488548, ENSP00000452861, ENSP00000437604, ENSP00000340858, ENSP00000483449, ENSP00000453186, ENSP00000488360, ENSP00000488177, ENSP00000488042, ENSP00000497910

Freebase id /m/0980nd

Microsoft academic id (discontinued) 21957315

Openalex id C21957315

Pdb structure id 1A1M, 1A1N, 1A1O, 1A6Z, 1A9B, 1A9E, 1AGB, 1AGC, 1AGD, 1AGE, 1AGF, 1AKJ, 1AO7, 1B0G, 1B0R, 1BD2, 1C16, 1CE6, 1DE4, 1DUY, 1DUZ, 1E27, 1E28, 1EEY, 1EEZ, 1EFX, 1EXU, 1GZP, 1GZQ, 1HHG, 1HHH, 1HHI, 1HHJ, 1HHK, 1HLA, 1HSA, 1HSB, 1I1F, 1I1Y, 1I4F, 1I7R, 1I7T, 1I7U, 1IM3, 1IM9, 1JF1, 1JGD, 1JGE, 1JHT, 1JNJ, 1K5N, 1KPR, 1KTL, 1LDS, 1LP9, 1M05, 1M6O, 1MHE, 1MI5, 1OF2, 1OGA, 1OGT, 1ONQ, 1PY4, 1Q94, 1QEW, 1QLF, 1QQD, 1QR1, 1QRN, 1QSE, 1QSF, 1QVO, 1R3H, 1S9W, 1S9X, 1S9Y, 1SYS, 1SYV, 1TMC, 1TVB, 1TVH, 1UQS, 1UXS, 1UXW, 1VGK, 1W0V, 1W0W, 1W72, 1X7Q, 1XH3, 1XR8, 1XR9, 1XZ0, 1YDP, 1YPZ, 1ZHK, 1ZHL, 1ZS8, 1ZSD, 1ZT4, 1ZVS, 2A83, 2AK4, 2AV7, 2AXF, 2AXG, 2BCK, 2BNQ, 2BNR, 2BSR, 2BSS, 2BST, 2BVO, 2BVP, 2BVQ, 2C7U, 2CII, 2CIK, 2CLR, 2D31, 2D4D, 2D4F, 2DYP, 2E8D, 2ESV, 2F53, 2F54, 2F74, 2F8O, 2GIT, 2GJ6, 2GT9, 2GTW, 2GTZ, 2GUO, 2H26, 2H6P, 2HJL, 2HLA, 2HN7, 2J8U, 2JCC, 2NW3, 2NX5, 2P5E, 2P5W, 2PO6, 2PYE, 2RFX, 2UWE, 2V2W, 2V2X, 2VB5, 2VLJ, 2VLK, 2VLL, 2VLR, 2X4N, 2X4O, 2X4P, 2X4Q, 2X4R, 2X4S, 2X4T, 2X4U, 2X70, 2X89, 2XKS, 2XKU, 2XPG, 2YPK, 2YPL, 2YXF, 2Z9T, 3AM8, 3B3I, 3B6S, 3BGM, 3BH8, 3BH9, 3BHB, 3BO8, 3BP4, 3BP7, 3BVN, 3BW9, 3BWA, 3BXN, 3BZE, 3BZF, 3C9N, 3CDG, 3CII, 3CIQ, 3CZF, 3D18, 3D25, 3D2U, 3D39, 3D3V, 3DBX, 3DHJ, 3DHM, 3DTX, 3DXA, 3EKC, 3FFC, 3FQN, 3FQR, 3FQT, 3FQU, 3FQW, 3FQX, 3FT2, 3FT3, 3FT4, 3GIV, 3GJF, 3GSN, 3GSO, 3GSQ, 3GSR, 3GSU, 3GSV, 3GSW, 3GSX, 3H7B, 3H9H, 3H9S, 3HAE, 3HCV, 3HG1, 3HLA, 3HPJ, 3HUJ, 3I6G, 3I6K, 3I6L, 3IB4, 3IXA, 3JTS, 3KLA, 3KPO, 3KPR, 3KPS, 3KWW, 3KXF, 3KYN, 3KYO, 3L3D, 3L3G, 3L3I, 3L3J, 3L3K, 3LKN, 3LKO, 3LKP, 3LKQ, 3LKR, 3LKS, 3LN4, 3LN5, 3LOW, 3LV3, 3M17, 3M1B, 3MGO, 3MGT, 3MR9, 3MRB, 3MRC, 3MRD, 3MRE, 3MRF, 3MRG, 3MRH, 3MRI, 3MRJ, 3MRK, 3MRL, 3MRM, 3MRN, 3MRO, 3MRP, 3MRQ, 3MRR, 3MV7, 3MV8, 3MV9, 3MYJ, 3MYZ, 3MZT, 3NA4, 3NFN, 3O3A, 3O3B, 3O3D, 3O3E, 3O4L, 3OX8, 3OXR, 3OXS, 3PWJ, 3PWL, 3PWN, 3PWP, 3QDA, 3QDG, 3QDJ, 3QDM, 3QEQ, 3QFD, 3QFJ, 3QZW, 3RL1, 3RWJ, 3S6C, 3SDX, 3SJV, 3SKM, 3SKO, 3SPV, 3T8X, 3TID, 3TIE, 3TLR, 3TM6, 3TO2, 3TZV, 3U0P, 3UPR, 3UTQ, 3UTS, 3UTT, 3V5D, 3V5H, 3V5K, 3VCL, 3VFR, 3VFS, 3VFT, 3VFU, 3VFV, 3VFW, 3VH8, 3VRI, 3VRJ, 3VWJ, 3VWK, 3W39, 4E0K, 4E0L, 4E5X, 4EN3, 4EUP, 4F7M, 4F7P, 4F7T, 4FTV, 4FXL, 4G8G, 4G8I, 4G9D, 4G9F, 4GKS, 4GUP, 4HKJ, 4I4W, 4JFD, 4JFE, 4JFF, 4JFO, 4JFP, 4JFQ, 4JQX, 4JRX, 4JRY, 4K7F, 4KDT, 4L4T, 4L4V, 1CG9, 1N2R, 1P7Q, 1S8D, 1T1W, 1T1X, 1T1Y, 1T1Z, 1T20, 1T21, 1T22, 2AV1, 2FYY, 2FZ3, 2HJK, 3DX6, 3DX7, 3DX8, 3KPL, 3KPM, 3KPN, 3KPP, 3KPQ, 3LOZ, 3OV6, 3REW, 3RL2, 3VXM, 3VXN, 3VXO, 3VXP, 3VXR, 3VXS, 3VXU, 3W0W, 3WL9, 3WLB, 3WUW, 3X11, 3X12, 3X13, 3X14, 4GKN, 4HWZ, 4HX1, 4I48, 4K71, 4L29, 4L3C, 4L3E, 4LCW, 4LCY, 4LHU, 4LNR, 4M8V, 4MJ5, 4MJ6, 4MJI, 4MNQ, 4N0F, 4N0U, 4N8V, 4NNX, 4NNY, 4NO0, 4NO2, 4NO3, 4NO5, 4NQC, 4NQD, 4NQE, 4NQV, 4NQX, 4NT6, 4O2C, 4O2E, 4O2F, 4ONO, 4PJ5, 4PJ7, 4PJ8, 4PJ9, 4PJA, 4PJB, 4PJC, 4PJD, 4PJE, 4PJF, 4PJG, 4PJH, 4PJI, 4PJX, 4PR5, 4PRA, 4PRB, 4PRD, 4PRE, 4PRH, 4PRI, 4PRN, 4PRP, 4QOK, 4QRP, 4QRQ, 4QRR, 4QRS, 4QRT, 4QRU, 4U1H, 4U1I, 4U1J, 4U1K, 4U1L, 4U1M, 4U1N, 4U1S, 4U6X, 4U6Y, 4UQ2, 4UQ3, 4WJ5, 4WO4, 4WU5, 4WU7, 4X6C, 4X6D, 4X6E, 4X6F, 4XXC, 4WDI, 4Z76, 4Z77, 4Z78, 4R9H, 4RA3, 4RAH, 5D2L, 5D2N, 4WW2, 5DEG, 4RMT, 5DEF, 4RMW, 4RMV, 4RMR, 5D7J, 4RMQ, 4RMS, 4WWK, 5BXF, 5D5M, 5D7L, 4RMU, 4WUU, 5D7I, 5EU5, 5EO0, 5EO1, 5EU4, 5BRZ, 5EU6, 5BS0, 5EU3, 5C9J, 5D9S, 5HGA, 5C0D, 5C0B, 5C0I, 5C0A, 5B38, 5E9D, 5B39, 5C0H, 5HHN, 5HGD, 5C08, 5CFH, 5CKG, 4ZEZ, 5C0C, 5HGH, 5C0J, 5HHQ, 5DDH, 5HHM, 5HGB, 5C09, 5HYJ, 5CKA, 5C07, 5HHP, 5C0G, 5C0F, 5HHO, 5C0E

Reaxys registry number 1416971

Refseq protein id NP_004039, XP_005254606

Transporter classification database id 9.A.75.1.2

Uniprot protein id P61769

🌐 Available in 13 languages

enBeta-2 microglobulin csBeta-2 mikroglobulin deΒ2-Mikroglobulin esBeta-2 microglobulina faبتا دو میکروگلوبولین frBêta-2 microglobuline idBeta-2 mikroglobulin itBeta 2 microglobulina jaΒ2-ミクログロブリン ruМикроглобулин бета-2 svBeta-2-mikroglobulin ukБета-2-мікроглобулін zhΒ2-微球蛋白

🏷️ Also known as

en B2M en beta-2-microglobin en β2 microglobulin en beta chain of MHC class I molecules en Beta-2-microglobulin en beta-2-microglobulin ar الجلوبلين المكروي بيتا-2 ar بيتا 2-المكروغلوبولين cs Beta-2 mikroglobulin de Beta-2-Mikroglobulin de B2m de β2-Mikroglobulin es Beta-2 Microglobulina fa بتا دو میکروگلوبولین fr Bêta-2 microglobuline it Beta 2 microglobulina it Beta-2 microglobulina ja Β2-ミクログロブリン pl beta-2-mikroglobulina ru Б2М

🔗 Connections

Cell component 9

plasma membrane, Golgi apparatus, cytosol, extracellular exosome, extracellular exosome, extracellular space, extracellular space, focal adhesion +1 more

Biological process 3

innate immune response, innate immune response, immune response

Found in taxon 1

Homo sapiens

Instance of 1

protein

Molecular function 1

protein binding

Part of 1

Immunoglobulin-like domain superfamily

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Beta-2-microglobulin. Retrieved October 16, 2026, from https://4ort.xyz/entity/beta-2-microglobulin

MLA

“Beta-2-microglobulin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 16 Oct. 2026, https://4ort.xyz/entity/beta-2-microglobulin.

BibTeX

@misc{4ortxyz_beta-2-microglobulin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Beta-2-microglobulin}}, year = {2026}, url = {https://4ort.xyz/entity/beta-2-microglobulin}, note = {Accessed: 2026-10-16}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Beta-2-microglobulin — https://4ort.xyz/entity/beta-2-microglobulin (retrieved 2026-10-16)

Canonical URL: https://4ort.xyz/entity/beta-2-microglobulin · Last refreshed: October 16, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

12d ago · Kersti Nebelsiek · 2026-10-04 view diff on Wikidata ↗

Sitelink count → 18

Biological process → positive regulation of receptor-mediated endocytosis, cellular response to iron ion, response to cadmium ion +35

Molecular function → protein binding, identical protein binding

Cell component → HFE-transferrin receptor complex, Golgi apparatus, phagocytic vesicle membrane +23

+ 11 other properties edited (see Wikidata diff for full list)

"/* wbsetclaim-create:2||1 */ Image: HLAA in complex with KRAS G12R peptide (VVVGARGVGK) - Beta-2-microglobulin 8K4V.png"

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