B-Raf proto-oncogene, serine/threonine kinase

mammalian protein found in Homo sapiens

Protein protein Q21109218

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B-Raf proto-oncogene, serine/threonine kinase

Summary

B-Raf proto-oncogene, serine/threonine kinase is a protein^[1].

Key Facts

B-Raf proto-oncogene, serine/threonine kinase's instance of is recorded as protein^[2].
B-Raf proto-oncogene, serine/threonine kinase's physically interacts with is recorded as dabrafenib^[3].
B-Raf proto-oncogene, serine/threonine kinase's physically interacts with is recorded as regorafenib^[4].
B-Raf proto-oncogene, serine/threonine kinase's physically interacts with is recorded as sorafenib^[5].
B-Raf proto-oncogene, serine/threonine kinase's physically interacts with is recorded as vemurafenib^[6].
B-Raf proto-oncogene, serine/threonine kinase is part of Ubiquitin-like domain superfamily^[7].
B-Raf proto-oncogene, serine/threonine kinase is part of Protein kinase-like domain superfamily^[8].
B-Raf proto-oncogene, serine/threonine kinase is part of Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[9].
B-Raf proto-oncogene, serine/threonine kinase is part of Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family^[10].
B-Raf proto-oncogene, serine/threonine kinase is part of Diacylglycerol/phorbol-ester binding domain, protein family^[11].
B-Raf proto-oncogene, serine/threonine kinase is part of Raf-like Ras-binding domain, protein family^[12].
B-Raf proto-oncogene, serine/threonine kinase is part of Protein kinase domain, protein family^[13].
B-Raf proto-oncogene, serine/threonine kinase is part of Protein kinase, ATP binding site, protein family^[14].
B-Raf proto-oncogene, serine/threonine kinase is part of Serine/threonine-protein kinase, active site, protein family^[15].
B-Raf proto-oncogene, serine/threonine kinase comprises Raf-like Ras-binding^[16].
B-Raf proto-oncogene, serine/threonine kinase comprises protein kinase, ATP binding site^[17].
B-Raf proto-oncogene, serine/threonine kinase comprises protein kinase domain^[18].
B-Raf proto-oncogene, serine/threonine kinase comprises protein kinase C-like, phorbol ester/diacylglycerol-binding domain^[19].
B-Raf proto-oncogene, serine/threonine kinase comprises serine/threonine-protein kinase, active site^[20].
B-Raf proto-oncogene, serine/threonine kinase comprises serine-threonine/tyrosine-protein kinase, catalytic domain^[21].
B-Raf proto-oncogene, serine/threonine kinase comprises diacylglycerol/phorbol-ester binding^[22].

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Quick Facts

Instance of protein

Part of Ubiquitin-like domain superfamily, Protein kinase-like domain superfamily, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family, Diacylglycerol/phorbol-ester binding domain, protein family, Raf-like Ras-binding domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Serine/threonine-protein kinase, active site, protein family

Properties

Biological process cellular response to calcium ion, intracellular signal transduction, phosphorylation, establishment of protein localization to membrane, negative regulation of apoptotic process, positive regulation of peptidyl-serine phosphorylation, protein phosphorylation, animal organ morphogenesis, signal transduction, negative regulation of signal transduction, positive regulation of glucose transmembrane transport, trehalose metabolism in response to stress, MAPK cascade, positive regulation of gene expression, cell differentiation, positive regulation of ERK1 and ERK2 cascade, MAPK cascade, myeloid progenitor cell differentiation, visual learning, positive regulation of gene expression, negative regulation of fibroblast migration, cell differentiation, thyroid gland development, somatic stem cell population maintenance, regulation of cell population proliferation, CD4-positive, alpha-beta T cell differentiation, positive T cell selection, CD4-positive or CD8-positive, alpha-beta T cell lineage commitment, response to peptide hormone, negative regulation of neuron apoptotic process, regulation of T cell differentiation, alpha-beta T cell differentiation, thymus development, regulation of axon regeneration, positive regulation of axon regeneration, positive regulation of axonogenesis, T cell receptor signaling pathway, protein heterooligomerization, positive regulation of stress fiber assembly, response to cAMP, long-term potentiation, head morphogenesis, face development, positive regulation of ERK1 and ERK2 cascade, positive regulation of substrate adhesion-dependent cell spreading, cellular response to nerve growth factor stimulus, negative regulation of synaptic vesicle exocytosis, negative regulation of endothelial cell apoptotic process, MAPK cascade

Cell component intracellular membrane-bounded organelle, membrane, nucleus, intracellular anatomical structure, cytoplasm, cytosol, plasma membrane, mitochondrion, cytosol, neuron projection, cell body, mitochondrion

Ec enzyme number 2.7.11.1

Encoded by BRAF

Found in taxon Homo sapiens

Has part(s) Raf-like Ras-binding, protein kinase, ATP binding site, protein kinase domain, protein kinase C-like, phorbol ester/diacylglycerol-binding domain, serine/threonine-protein kinase, active site, serine-threonine/tyrosine-protein kinase, catalytic domain, diacylglycerol/phorbol-ester binding

Molecular function protein kinase activity, calcium ion binding, nucleotide binding, transferase activity, metal ion binding, kinase activity, protein serine/threonine kinase activity, small GTPase binding, protein binding, identical protein binding, ATP binding, MAP kinase kinase kinase activity, mitogen-activated protein kinase kinase binding, protein serine/threonine kinase activity, MAP kinase kinase kinase activity, mitogen-activated protein kinase kinase binding, protein heterodimerization activity

Physically interacts with dabrafenib, regorafenib, sorafenib, vemurafenib

External References (7)

Ensembl protein id ENSP00000288602, ENSP00000418033, ENSP00000419060, ENSP00000420119, ENSP00000495858, ENSP00000496776, ENSP00000494784, ENSP00000493543, ENSP00000493678, ENSP00000495132, ENSP00000493783

Mesh descriptor id D048493

Mesh tree code D08.811.913.696.620.682.700.559.842.374, D12.776.476.563.554.842.437, D12.776.624.664.700.204.200

Pdb structure id 1UWH, 1UWJ, 2FB8, 2L05, 3C4C, 3D4Q, 3IDP, 3II5, 3NY5, 3OG7, 3PPJ, 3PPK, 3PRF, 3PRI, 3PSB, 3PSD, 3Q4C, 3Q96, 3SKC, 3TV4, 3TV6, 4DBN, 4E26, 4E4X, 4EHE, 4EHG, 4FC0, 4FK3, 4G9C, 4G9R, 4H58, 4JVG, 4KSP, 4KSQ, 4MBJ, 4MNE, 4MNF, 4PP7, 4WO5, 5C9C, 5CT7, 4XV2, 4XV1, 4XV9, 4XV3, 4R5Y, 5CSW, 5CSX, 4YHT, 5J2R, 5FD2, 5HIE, 5HID, 5HI2, 4CQE, 5J18

Refseq protein id NP_004324, XP_016868048, NP_001341538, NP_001361173, NP_001361187, NP_001365396, NP_001365397, NP_001365398, NP_001365399, NP_001365400, NP_001365401, NP_001365402, NP_001365403, NP_001365404

Umls cui C0104940

Uniprot protein id P15056

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ B-Raf proto-oncogene, serine/threonine kinase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ B-Raf proto-oncogene, serine/threonine kinase — physically interacts with (P129): dabrafenib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ B-Raf proto-oncogene, serine/threonine kinase — physically interacts with (P129): regorafenib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ B-Raf proto-oncogene, serine/threonine kinase — physically interacts with (P129): sorafenib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[6] ↑ B-Raf proto-oncogene, serine/threonine kinase — physically interacts with (P129): vemurafenib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[7] ↑ B-Raf proto-oncogene, serine/threonine kinase — part of (P361): Ubiquitin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ B-Raf proto-oncogene, serine/threonine kinase — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ B-Raf proto-oncogene, serine/threonine kinase — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[10] ↑ B-Raf proto-oncogene, serine/threonine kinase — part of (P361): Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family. wikidata.org.
[11] ↑ B-Raf proto-oncogene, serine/threonine kinase — part of (P361): Diacylglycerol/phorbol-ester binding domain, protein family. wikidata.org.
[12] ↑ B-Raf proto-oncogene, serine/threonine kinase — part of (P361): Raf-like Ras-binding domain, protein family. wikidata.org.
[13] ↑ B-Raf proto-oncogene, serine/threonine kinase — part of (P361): Protein kinase domain, protein family. wikidata.org.
[14] ↑ B-Raf proto-oncogene, serine/threonine kinase — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[15] ↑ B-Raf proto-oncogene, serine/threonine kinase — part of (P361): Serine/threonine-protein kinase, active site, protein family. wikidata.org.
[16] ↑ B-Raf proto-oncogene, serine/threonine kinase — has part(s) (P527): Raf-like Ras-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ B-Raf proto-oncogene, serine/threonine kinase — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ B-Raf proto-oncogene, serine/threonine kinase — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ B-Raf proto-oncogene, serine/threonine kinase — has part(s) (P527): protein kinase C-like, phorbol ester/diacylglycerol-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ B-Raf proto-oncogene, serine/threonine kinase — has part(s) (P527): serine/threonine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ B-Raf proto-oncogene, serine/threonine kinase — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ B-Raf proto-oncogene, serine/threonine kinase — has part(s) (P527): diacylglycerol/phorbol-ester binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ B-Raf proto-oncogene, serine/threonine kinase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). B-Raf proto-oncogene, serine/threonine kinase. Retrieved May 3, 2026, from https://4ort.xyz/entity/b-raf-proto-oncogene-serine-threonine-kinase

MLA

“B-Raf proto-oncogene, serine/threonine kinase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/b-raf-proto-oncogene-serine-threonine-kinase.

BibTeX

@misc{4ortxyz_b-raf-proto-oncogene-serine-threonine-kinase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{B-Raf proto-oncogene, serine/threonine kinase}}, year = {2026}, url = {https://4ort.xyz/entity/b-raf-proto-oncogene-serine-threonine-kinase}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): B-Raf proto-oncogene, serine/threonine kinase — https://4ort.xyz/entity/b-raf-proto-oncogene-serine-threonine-kinase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/b-raf-proto-oncogene-serine-threonine-kinase · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Found in taxon → Homo sapiens

Physically interacts with → dabrafenib, regorafenib, sorafenib +1

Wikidata description → mammalian protein found in Homo sapiens

Mesh tree code → D08.811.913.696.620.682.700.559.842.374, D12.776.476.563.554.842.437, D12.776.624.664.700.204.200

+ 16 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.11.1, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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