ATPase copper transporting alpha

mammalian protein found in Homo sapiens

Protein protein Q4654858

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ATPase copper transporting alpha

Summary

ATPase copper transporting alpha is a protein^[1].

Key Facts

ATPase copper transporting alpha's instance of is recorded as protein^[2].
ATPase copper transporting alpha is part of P-type ATPase, A domain superfamily^[3].
ATPase copper transporting alpha is part of P-type ATPase, subfamily IB^[4].
ATPase copper transporting alpha is part of Heavy metal-associated domain superfamily^[5].
ATPase copper transporting alpha is part of P-type ATPase, cytoplasmic domain N^[6].
ATPase copper transporting alpha is part of P-type ATPase, transmembrane domain superfamily^[7].
ATPase copper transporting alpha is part of HAD-like superfamily^[8].
ATPase copper transporting alpha is part of P-type ATPase^[9].
ATPase copper transporting alpha is part of Heavy metal-associated domain, HMA, protein family^[10].
ATPase copper transporting alpha is part of Heavy metal-associated domain, copper ion-binding domain, protein family^[11].
ATPase copper transporting alpha is part of Heavy-metal-associated, conserved site, protein family^[12].
ATPase copper transporting alpha comprises Heavy metal-associated domain, HMA^[13].
ATPase copper transporting alpha comprises Heavy-metal-associated, conserved site^[14].
ATPase copper transporting alpha comprises Heavy metal-associated domain, copper ion-binding^[15].
ATPase copper transporting alpha comprises P-type ATPase, phosphorylation site^[16].
ATPase copper transporting alpha's molecular function is recorded as nucleotide binding^[17].
ATPase copper transporting alpha's molecular function is recorded as copper ion binding^[18].
ATPase copper transporting alpha's molecular function is recorded as metal ion binding^[19].
ATPase copper transporting alpha's molecular function is recorded as hydrolase activity^[20].
ATPase copper transporting alpha's molecular function is recorded as ATPase-coupled cation transmembrane transporter activity^[21].
ATPase copper transporting alpha's molecular function is recorded as copper ion transmembrane transporter activity^[22].
ATPase copper transporting alpha's molecular function is recorded as ATP binding^[23].
ATPase copper transporting alpha's molecular function is recorded as superoxide dismutase copper chaperone activity^[24].
ATPase copper transporting alpha's molecular function is recorded as copper-dependent protein binding^[25].
ATPase copper transporting alpha's molecular function is recorded as protein binding^[26].

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Quick Facts

Instance of protein

Part of P-type ATPase, A domain superfamily, P-type ATPase, subfamily IB, Heavy metal-associated domain superfamily, P-type ATPase, cytoplasmic domain N, P-type ATPase, transmembrane domain superfamily, HAD-like superfamily, P-type ATPase, Heavy metal-associated domain, HMA, protein family, Heavy metal-associated domain, copper ion-binding domain, protein family, Heavy-metal-associated, conserved site, protein family

Properties

Biological process norepinephrine metabolic process, response to iron(III) ion, removal of superoxide radicals, detoxification of copper ion, copper ion import, neuron projection morphogenesis, pyramidal neuron development, extracellular matrix organization, collagen fibril organization, dopamine metabolic process, T-helper cell differentiation, skin development, tryptophan metabolic process, response to zinc ion, regulation of oxidative phosphorylation, locomotory behavior, cartilage development, response to copper ion, positive regulation of oxidoreductase activity, pigmentation, serotonin metabolic process, ion transport, blood vessel development, mitochondrion organization, cerebellar Purkinje cell differentiation, elastic fiber assembly, central nervous system neuron development, cation transport, in utero embryonic development, ion transmembrane transport, lung alveolus development, blood vessel remodeling, peptidyl-lysine modification, catecholamine metabolic process, metal ion transport, hair follicle morphogenesis, plasma membrane copper ion transport, lactation, positive regulation of catalytic activity, epinephrine metabolic process, elastin biosynthetic process, cellular copper ion homeostasis, copper ion transport, negative regulation of catalytic activity, liver development, response to manganese ion, response to lead ion, regulation of gene expression, positive regulation of lamellipodium assembly, antimicrobial humoral response, negative regulation of iron ion transmembrane transport, cellular response to platelet-derived growth factor stimulus, positive regulation of cell size, positive regulation of epithelial cell proliferation, cellular response to amino acid stimulus, cellular response to antibiotic, cellular response to cadmium ion, cellular response to cobalt ion, cellular response to copper ion, cellular response to iron ion, cellular response to lead ion, cellular response to hypoxia, positive regulation of response to wounding, positive regulation of vascular associated smooth muscle cell migration, regulation of cytochrome-c oxidase activity, copper ion export, transport, cellular copper ion homeostasis, copper ion export

Cell component trans-Golgi network transport vesicle, cytoplasm, integral component of membrane, trans-Golgi network, Golgi apparatus, cytosol, neuron projection, membrane, soma, endoplasmic reticulum, perinuclear region of cytoplasm, brush border membrane, basolateral plasma membrane, secretory granule, plasma membrane, nucleus, late endosome, microvillus, apical plasma membrane, phagocytic vesicle membrane, cell leading edge, perikaryon, membrane raft, endoplasmic reticulum, trans-Golgi network, membrane, perinuclear region of cytoplasm

Ec enzyme number 7.2.2.8

Encoded by ATP7A

Found in taxon Homo sapiens

Has part(s) Heavy metal-associated domain, HMA, Heavy-metal-associated, conserved site, Heavy metal-associated domain, copper ion-binding, P-type ATPase, phosphorylation site

Molecular function nucleotide binding, copper ion binding, metal ion binding, hydrolase activity, ATPase-coupled cation transmembrane transporter activity, copper ion transmembrane transporter activity, ATP binding, superoxide dismutase copper chaperone activity, copper-dependent protein binding, protein binding, chaperone binding, P-type divalent copper transporter activity, cuprous ion binding, P-type divalent copper transporter activity, copper ion transmembrane transporter activity, P-type divalent copper transporter activity

External References (5)

Ensembl protein id ENSP00000343026, ENSP00000345728, ENSP00000495628, ENSP00000493605, ENSP00000496603

Pdb structure id 1AW0, 1KVI, 1KVJ, 1Q8L, 1S6O, 1S6U, 1Y3J, 1Y3K, 1YJR, 1YJT, 1YJU, 1YJV, 2G9O, 2GA7, 2K1R, 2KIJ, 2KMV, 2KMX, 3CJK

Refseq protein id NP_000043, NP_001269153

Transporter classification database id 3.A.3.5.6

Uniprot protein id Q04656

🏷️ Also known as

en ATP7A en ATPase copper transporting alpha en ATPase, Cu++ transporting, alpha polypeptide en copper pump 1 en copper-transporting ATPase 1 en Cu++-transporting P-type ATPase en Menkes disease-associated protein

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ ATPase copper transporting alpha — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ ATPase copper transporting alpha — part of (P361): P-type ATPase, A domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ ATPase copper transporting alpha — part of (P361): P-type ATPase, subfamily IB. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ ATPase copper transporting alpha — part of (P361): Heavy metal-associated domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ ATPase copper transporting alpha — part of (P361): P-type ATPase, cytoplasmic domain N. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ ATPase copper transporting alpha — part of (P361): P-type ATPase, transmembrane domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ ATPase copper transporting alpha — part of (P361): HAD-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ ATPase copper transporting alpha — part of (P361): P-type ATPase. Retrieved 2019-10-02. wikidata.org.
[10] ↑ ATPase copper transporting alpha — part of (P361): Heavy metal-associated domain, HMA, protein family. wikidata.org.
[11] ↑ ATPase copper transporting alpha — part of (P361): Heavy metal-associated domain, copper ion-binding domain, protein family. wikidata.org.
[12] ↑ ATPase copper transporting alpha — part of (P361): Heavy-metal-associated, conserved site, protein family. wikidata.org.
[13] ↑ ATPase copper transporting alpha — has part(s) (P527): Heavy metal-associated domain, HMA. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ ATPase copper transporting alpha — has part(s) (P527): Heavy-metal-associated, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ ATPase copper transporting alpha — has part(s) (P527): Heavy metal-associated domain, copper ion-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ ATPase copper transporting alpha — has part(s) (P527): P-type ATPase, phosphorylation site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ ATPase copper transporting alpha — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ ATPase copper transporting alpha — molecular function (P680): copper ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ ATPase copper transporting alpha — molecular function (P680): metal ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ ATPase copper transporting alpha — molecular function (P680): hydrolase activity. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ ATPase copper transporting alpha — molecular function (P680): ATPase-coupled cation transmembrane transporter activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ ATPase copper transporting alpha — molecular function (P680): copper ion transmembrane transporter activity. GOA. Retrieved 2017-09-26. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ ATPase copper transporting alpha — molecular function (P680): ATP binding. A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ ATPase copper transporting alpha — molecular function (P680): superoxide dismutase copper chaperone activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ ATPase copper transporting alpha — molecular function (P680): copper-dependent protein binding. Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ ATPase copper transporting alpha — molecular function (P680): protein binding. A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ ATPase copper transporting alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“ATPase copper transporting alpha.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/atpase-copper-transporting-alpha-q4654858.

BibTeX

@misc{4ortxyz_atpase-copper-transporting-alpha-q4654858_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{ATPase copper transporting alpha}}, year = {2026}, url = {https://4ort.xyz/entity/atpase-copper-transporting-alpha-q4654858}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): ATPase copper transporting alpha — https://4ort.xyz/entity/atpase-copper-transporting-alpha-q4654858 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/atpase-copper-transporting-alpha-q4654858 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

11w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → Q04656

Transporter classification database id → 3.A.3.5.6

Ec enzyme number → 7.2.2.8

Refseq protein id → NP_000043, NP_001269153

+ 12 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 7.2.2.8, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"

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