Properties
Biological process
proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of calcium ion transport, regulation of protein phosphorylation, negative regulation of interleukin-1 beta production, negative regulation of protein kinase B signaling, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of protein kinase B signaling, positive regulation of protein phosphorylation, endocytosis, regulation of G protein-coupled receptor signaling pathway, positive regulation of receptor internalization, negative regulation of release of cytochrome c from mitochondria, negative regulation of interleukin-6 production, receptor internalization, transcription by RNA polymerase II, positive regulation of peptidyl-serine phosphorylation, detection of temperature stimulus involved in sensory perception of pain, follicle-stimulating hormone signaling pathway, platelet activation, dopamine receptor signaling pathway, negative regulation of protein ubiquitination, brain development, negative regulation of GTPase activity, negative regulation of toll-like receptor signaling pathway, protein ubiquitination, positive regulation of DNA biosynthetic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of peptidyl-tyrosine phosphorylation, cell chemotaxis, protein transport, negative regulation of natural killer cell mediated cytotoxicity, regulation of androgen receptor signaling pathway, positive regulation of synaptic transmission, dopaminergic, negative regulation of tumor necrosis factor production, negative regulation of signal transduction, positive regulation of protein ubiquitination, transforming growth factor beta receptor signaling pathway, negative regulation of NF-kappaB transcription factor activity, negative regulation of smooth muscle cell apoptotic process, desensitization of G protein-coupled receptor signaling pathway by arrestin, signal transduction, adult walking behavior, negative regulation of interleukin-12 production, Wnt signaling pathway, planar cell polarity pathway, negative regulation of protein phosphorylation, G protein-coupled receptor internalization, positive regulation of gene expression, protein deubiquitination, membrane organization, positive regulation of cardiac muscle cell differentiation, G protein-coupled receptor signaling pathway, excitatory postsynaptic potential, positive regulation of collagen biosynthetic process, negative regulation of neuron apoptotic process, positive regulation of epithelial cell apoptotic process, G protein-coupled receptor internalization, positive regulation of ERK1 and ERK2 cascade
Cell component
cytoplasm, cytosol, postsynaptic membrane, postsynaptic density, membrane, plasma membrane, endocytic vesicle, dendritic spine, intracellular anatomical structure, basolateral plasma membrane, clathrin-coated pit, cytoplasmic vesicle, nucleus, intracellular membrane-bounded organelle, endosome, cytoplasm
Has part(s)
Arrestin-like, N-terminal, Arrestin, conserved site, Arrestin C-terminal-like domain
Imported from
wholeness_audit_2026-05-02
Molecular function
alpha-1B adrenergic receptor binding, 14-3-3 protein binding, protein kinase B binding, protein binding, enzyme binding, angiotensin receptor binding, molecular adaptor activity, signaling receptor binding, G protein-coupled receptor binding, ubiquitin protein ligase binding, identical protein binding, arrestin family protein binding, protein-containing complex binding, protein domain specific binding, alpha-1A adrenergic receptor binding, type 1 angiotensin receptor binding, D1 dopamine receptor binding, follicle-stimulating hormone receptor binding, type 2A serotonin receptor binding, platelet activating factor receptor binding, mitogen-activated protein kinase binding, G protein-coupled receptor binding, angiotensin receptor binding
External References (6)
Ensembl protein id
ENSP00000269260, ENSP00000341895, ENSP00000370898, ENSP00000403701, ENSP00000458371, ENSP00000458946, ENSP00000460607, ENSP00000460879, ENSP00000465296, ENSP00000465877, ENSP00000466344, ENSP00000466857
Mesh descriptor id
D000071560
Mesh tree code
D12.644.360.024.098.525.750, D12.776.157.057.005.525.750, D12.776.476.024.104.525.750, D12.776.543.090.525.750
Refseq protein id
NP_001244257, NP_001244258, NP_001244259, NP_001244260, NP_001316993, NP_004304, NP_945355, XP_011522160, XP_016880134, XP_024306519, XP_024306520, XP_024306521
Umls cui
C0287638
Uniprot protein id
P32121