Argonaute RISC catalytic subunit 2

mammalian protein found in Mus musculus

Protein protein Q21498903

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Argonaute RISC catalytic subunit 2

Summary

Argonaute RISC catalytic subunit 2 is a protein^[1].

Key Facts

Argonaute RISC catalytic subunit 2's instance of is recorded as protein^[2].
Argonaute RISC catalytic subunit 2's subclass of is recorded as protein^[3].
Argonaute RISC catalytic subunit 2's UniProt protein ID is recorded as Q8CJG0^[4].
Argonaute RISC catalytic subunit 2's part of is recorded as Ribonuclease H superfamily^[5].
Argonaute RISC catalytic subunit 2's part of is recorded as PAZ domain superfamily^[6].
Argonaute RISC catalytic subunit 2's part of is recorded as Ribonuclease H-like superfamily^[7].
Argonaute RISC catalytic subunit 2's part of is recorded as Protein argonaute-2^[8].
Argonaute RISC catalytic subunit 2's part of is recorded as Protein argonaute, N-terminal domain, protein family^[9].
Argonaute RISC catalytic subunit 2's part of is recorded as Piwi domain, protein family^[10].
Argonaute RISC catalytic subunit 2's part of is recorded as Argonaute linker 2 domain, protein family^[11].
Argonaute RISC catalytic subunit 2's part of is recorded as PAZ domain, protein family^[12].
Argonaute RISC catalytic subunit 2's part of is recorded as Protein argonaute, Mid domain, protein family^[13].
Argonaute RISC catalytic subunit 2's part of is recorded as Argonaute, linker 1 domain, protein family^[14].
Argonaute RISC catalytic subunit 2's has part is recorded as Argonaute, linker 1 domain^[15].
Argonaute RISC catalytic subunit 2's has part is recorded as Piwi domain^[16].
Argonaute RISC catalytic subunit 2's has part is recorded as PAZ domain^[17].
Argonaute RISC catalytic subunit 2's has part is recorded as Argonaute linker 2 domain^[18].
Argonaute RISC catalytic subunit 2's has part is recorded as Protein argonaute, Mid domain^[19].
Argonaute RISC catalytic subunit 2's has part is recorded as Protein argonaute, N-terminal^[20].
Argonaute RISC catalytic subunit 2's RefSeq protein ID is recorded as NP_694818^[21].
Argonaute RISC catalytic subunit 2's molecular function is recorded as endoribonuclease activity, cleaving siRNA-paired mRNA^[22].
Argonaute RISC catalytic subunit 2's molecular function is recorded as RNA polymerase II complex binding^[23].
Argonaute RISC catalytic subunit 2's molecular function is recorded as RNA 7-methylguanosine cap binding^[24].
Argonaute RISC catalytic subunit 2's molecular function is recorded as miRNA binding^[25].
Argonaute RISC catalytic subunit 2's molecular function is recorded as endoribonuclease activity^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Ribonuclease H superfamily, PAZ domain superfamily, Ribonuclease H-like superfamily, Protein argonaute-2, Protein argonaute, N-terminal domain, protein family, Piwi domain, protein family, Argonaute linker 2 domain, protein family, PAZ domain, protein family, Protein argonaute, Mid domain, protein family, Argonaute, linker 1 domain, protein family

Properties

Biological process mRNA destabilization-mediated gene silencing by siRNA, cell differentiation, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, regulation of transcription, DNA-templated, negative regulation of translational initiation, post-embryonic development, transcription, DNA-templated, multicellular organism development, pre-miRNA processing, positive regulation of gene expression, miRNA-mediated gene silencing by inhibition of translation, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, RNA secondary structure unwinding, mRNA destabilization-mediated gene silencing by miRNA, miRNA metabolic process, gene silencing, regulation of translation, positive regulation of transcription by RNA polymerase II, production of miRNAs involved in gene silencing by miRNA, RNA phosphodiester bond hydrolysis, endonucleolytic, positive regulation of angiogenesis, positive regulation of trophoblast cell migration, negative regulation of amyloid precursor protein biosynthetic process

Cell component cytoplasm, polysome, cytosol, RISC complex, P-body, RISC-loading complex, mRNA cap binding complex, dendrite, nucleus, nucleoplasm, cell junction, extracellular exosome, mitochondrion, ribonucleoprotein complex, nucleus

Encoded by Ago2

Found in taxon house mouse

Has part(s) Argonaute, linker 1 domain, Piwi domain, PAZ domain, Argonaute linker 2 domain, Protein argonaute, Mid domain, Protein argonaute, N-terminal

Imported from wholeness_audit_2026-05-02

Molecular function endoribonuclease activity, cleaving siRNA-paired mRNA, RNA polymerase II complex binding, RNA 7-methylguanosine cap binding, miRNA binding, endoribonuclease activity, metal ion binding, protein C-terminus binding, protein binding, single-stranded RNA binding, siRNA binding, nucleic acid binding, endoribonuclease activity, cleaving miRNA-paired mRNA, nuclease activity, double-stranded RNA binding, endonuclease activity, mRNA binding, hydrolase activity, mRNA cap binding, RNA binding, endoribonuclease activity, producing 5'-phosphomonoesters

External References (3)

Ensembl protein id ENSMUSP00000042207

Refseq protein id NP_694818

Uniprot protein id Q8CJG0

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Argonaute RISC catalytic subunit 2 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Argonaute RISC catalytic subunit 2 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Argonaute RISC catalytic subunit 2 — UniProt protein ID (P352): Q8CJG0. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Argonaute RISC catalytic subunit 2 — part of (P361): Ribonuclease H superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Argonaute RISC catalytic subunit 2 — part of (P361): PAZ domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Argonaute RISC catalytic subunit 2 — part of (P361): Ribonuclease H-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Argonaute RISC catalytic subunit 2 — part of (P361): Protein argonaute-2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Argonaute RISC catalytic subunit 2 — part of (P361): Protein argonaute, N-terminal domain, protein family. wikidata.org.
[10] ↑ Argonaute RISC catalytic subunit 2 — part of (P361): Piwi domain, protein family. wikidata.org.
[11] ↑ Argonaute RISC catalytic subunit 2 — part of (P361): Argonaute linker 2 domain, protein family. wikidata.org.
[12] ↑ Argonaute RISC catalytic subunit 2 — part of (P361): PAZ domain, protein family. wikidata.org.
[13] ↑ Argonaute RISC catalytic subunit 2 — part of (P361): Protein argonaute, Mid domain, protein family. wikidata.org.
[14] ↑ Argonaute RISC catalytic subunit 2 — part of (P361): Argonaute, linker 1 domain, protein family. wikidata.org.
[15] ↑ Argonaute RISC catalytic subunit 2 — has part(s) (P527): Argonaute, linker 1 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Argonaute RISC catalytic subunit 2 — has part(s) (P527): Piwi domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Argonaute RISC catalytic subunit 2 — has part(s) (P527): PAZ domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Argonaute RISC catalytic subunit 2 — has part(s) (P527): Argonaute linker 2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Argonaute RISC catalytic subunit 2 — has part(s) (P527): Protein argonaute, Mid domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Argonaute RISC catalytic subunit 2 — has part(s) (P527): Protein argonaute, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Argonaute RISC catalytic subunit 2 — RefSeq protein ID (P637): NP_694818. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Argonaute RISC catalytic subunit 2 — molecular function (P680): endoribonuclease activity, cleaving siRNA-paired mRNA. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Argonaute RISC catalytic subunit 2 — molecular function (P680): RNA polymerase II complex binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Argonaute RISC catalytic subunit 2 — molecular function (P680): RNA 7-methylguanosine cap binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Argonaute RISC catalytic subunit 2 — molecular function (P680): miRNA binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Argonaute RISC catalytic subunit 2 — molecular function (P680): endoribonuclease activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Argonaute RISC catalytic subunit 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Argonaute RISC catalytic subunit 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/argonaute-risc-catalytic-subunit-2

MLA

“Argonaute RISC catalytic subunit 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/argonaute-risc-catalytic-subunit-2.

BibTeX

@misc{4ortxyz_argonaute-risc-catalytic-subunit-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Argonaute RISC catalytic subunit 2}}, year = {2026}, url = {https://4ort.xyz/entity/argonaute-risc-catalytic-subunit-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Argonaute RISC catalytic subunit 2 — https://4ort.xyz/entity/argonaute-risc-catalytic-subunit-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/argonaute-risc-catalytic-subunit-2 · Last refreshed: May 3, 2026