Argonaute RISC catalytic component 2

mammalian protein found in Homo sapiens

Protein protein Q21115073

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Argonaute RISC catalytic component 2

Summary

Argonaute RISC catalytic component 2 is a protein^[1].

Key Facts

Argonaute RISC catalytic component 2's instance of is recorded as protein^[2].
Argonaute RISC catalytic component 2's UniProt protein ID is recorded as Q9UKV8^[3].
Argonaute RISC catalytic component 2's part of is recorded as Ribonuclease H superfamily^[4].
Argonaute RISC catalytic component 2's part of is recorded as PAZ domain superfamily^[5].
Argonaute RISC catalytic component 2's part of is recorded as Ribonuclease H-like superfamily^[6].
Argonaute RISC catalytic component 2's part of is recorded as Protein argonaute-2^[7].
Argonaute RISC catalytic component 2's part of is recorded as Protein argonaute, N-terminal domain, protein family^[8].
Argonaute RISC catalytic component 2's part of is recorded as Piwi domain, protein family^[9].
Argonaute RISC catalytic component 2's part of is recorded as Argonaute linker 2 domain, protein family^[10].
Argonaute RISC catalytic component 2's part of is recorded as PAZ domain, protein family^[11].
Argonaute RISC catalytic component 2's part of is recorded as Protein argonaute, Mid domain, protein family^[12].
Argonaute RISC catalytic component 2's part of is recorded as Argonaute, linker 1 domain, protein family^[13].
Argonaute RISC catalytic component 2's has part is recorded as Argonaute linker 2 domain^[14].
Argonaute RISC catalytic component 2's has part is recorded as Protein argonaute, N-terminal^[15].
Argonaute RISC catalytic component 2's has part is recorded as PAZ domain^[16].
Argonaute RISC catalytic component 2's has part is recorded as Piwi domain^[17].
Argonaute RISC catalytic component 2's has part is recorded as Protein argonaute, Mid domain^[18].
Argonaute RISC catalytic component 2's has part is recorded as Argonaute, linker 1 domain^[19].
Argonaute RISC catalytic component 2's RefSeq protein ID is recorded as NP_001158095^[20].
Argonaute RISC catalytic component 2's RefSeq protein ID is recorded as NP_036286^[21].
Argonaute RISC catalytic component 2's RefSeq protein ID is recorded as XP_011515267^[22].
Argonaute RISC catalytic component 2's RefSeq protein ID is recorded as XP_011515268^[23].
Argonaute RISC catalytic component 2's RefSeq protein ID is recorded as XP_011515270^[24].
Argonaute RISC catalytic component 2's RefSeq protein ID is recorded as XP_016868806^[25].
Argonaute RISC catalytic component 2's PDB structure ID is recorded as 3LUC^[26].

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Quick Facts

Instance of protein

Part of Ribonuclease H superfamily, PAZ domain superfamily, Ribonuclease H-like superfamily, Protein argonaute-2, Protein argonaute, N-terminal domain, protein family, Piwi domain, protein family, Argonaute linker 2 domain, protein family, PAZ domain, protein family, Protein argonaute, Mid domain, protein family, Argonaute, linker 1 domain, protein family

Properties

Biological process mRNA destabilization-mediated gene silencing by miRNA, RNA secondary structure unwinding, transcription, DNA-templated, regulation of translation, RNA interference, protein biosynthesis, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of gene expression, production of miRNAs involved in gene silencing by miRNA, mRNA destabilization-mediated gene silencing by siRNA, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, pre-miRNA processing, regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, post-embryonic development, RNA phosphodiester bond hydrolysis, endonucleolytic, translational initiation, Wnt signaling pathway, calcium modulating pathway, miRNA-mediated gene silencing by inhibition of translation, negative regulation of translational initiation, miRNA metabolic process, production of siRNA involved in RNA interference, gene silencing, regulation of gene silencing by miRNA, positive regulation of gene expression, negative regulation of gene expression, miRNA-mediated gene silencing by inhibition of translation, positive regulation of angiogenesis, negative regulation of translational initiation, positive regulation of trophoblast cell migration, negative regulation of amyloid precursor protein biosynthetic process

Cell component cytoplasm, polysome, membrane, P-body, dendrite, RISC-loading complex, RISC complex, cytosol, nucleus, nucleoplasm, mRNA cap binding complex, cell junction, extracellular exosome, mRNA cap binding complex, membrane, ribonucleoprotein complex, nucleus, RISC complex

Encoded by AGO2

Found in taxon Homo sapiens

Has part(s) Argonaute linker 2 domain, Protein argonaute, N-terminal, PAZ domain, Piwi domain, Protein argonaute, Mid domain, Argonaute, linker 1 domain

Imported from wholeness_audit_2026-05-02

Molecular function protein binding, protein C-terminus binding, metal ion binding, nuclease activity, endoribonuclease activity, cleaving miRNA-paired mRNA, hydrolase activity, translation initiation factor activity, endonuclease activity, endoribonuclease activity, cleaving siRNA-paired mRNA, single-stranded RNA binding, double-stranded RNA binding, RNA polymerase II complex binding, nucleic acid binding, mRNA binding, miRNA binding, endoribonuclease activity, RNA 7-methylguanosine cap binding, siRNA binding, mRNA cap binding, RNA binding, RNA 7-methylguanosine cap binding, RNA binding, endoribonuclease activity, producing 5'-phosphomonoesters, siRNA binding, endoribonuclease activity

External References (4)

Ensembl protein id ENSP00000220592, ENSP00000430176, ENSP00000430164, ENSP00000431056

Pdb structure id 3LUC, 3LUD, 3LUG, 3LUH, 3LUJ, 3LUK, 3QX8, 3QX9, 4F3T, 4OLA, 4OLB, 4W5N, 4W5O, 4W5Q, 4W5R, 4W5T, 4Z4C, 4Z4D, 4Z4E, 4Z4F, 4Z4G, 4Z4H, 4Z4I, 5JS1, 5JS2

Refseq protein id NP_001158095, NP_036286, XP_011515267, XP_011515268, XP_011515270, XP_016868806

Uniprot protein id Q9UKV8

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Argonaute RISC catalytic component 2 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Argonaute RISC catalytic component 2 — UniProt protein ID (P352): Q9UKV8. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Argonaute RISC catalytic component 2 — part of (P361): Ribonuclease H superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Argonaute RISC catalytic component 2 — part of (P361): PAZ domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Argonaute RISC catalytic component 2 — part of (P361): Ribonuclease H-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Argonaute RISC catalytic component 2 — part of (P361): Protein argonaute-2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Argonaute RISC catalytic component 2 — part of (P361): Protein argonaute, N-terminal domain, protein family. wikidata.org.
[9] ↑ Argonaute RISC catalytic component 2 — part of (P361): Piwi domain, protein family. wikidata.org.
[10] ↑ Argonaute RISC catalytic component 2 — part of (P361): Argonaute linker 2 domain, protein family. wikidata.org.
[11] ↑ Argonaute RISC catalytic component 2 — part of (P361): PAZ domain, protein family. wikidata.org.
[12] ↑ Argonaute RISC catalytic component 2 — part of (P361): Protein argonaute, Mid domain, protein family. wikidata.org.
[13] ↑ Argonaute RISC catalytic component 2 — part of (P361): Argonaute, linker 1 domain, protein family. wikidata.org.
[14] ↑ Argonaute RISC catalytic component 2 — has part(s) (P527): Argonaute linker 2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Argonaute RISC catalytic component 2 — has part(s) (P527): Protein argonaute, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Argonaute RISC catalytic component 2 — has part(s) (P527): PAZ domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Argonaute RISC catalytic component 2 — has part(s) (P527): Piwi domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Argonaute RISC catalytic component 2 — has part(s) (P527): Protein argonaute, Mid domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Argonaute RISC catalytic component 2 — has part(s) (P527): Argonaute, linker 1 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Argonaute RISC catalytic component 2 — RefSeq protein ID (P637): NP_001158095. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ Argonaute RISC catalytic component 2 — RefSeq protein ID (P637): NP_036286. Q20641742. Retrieved 2020-05-30. wikidata.org.
[22] ↑ Argonaute RISC catalytic component 2 — RefSeq protein ID (P637): XP_011515267. Q20641742. Retrieved 2020-05-30. wikidata.org.
[23] ↑ Argonaute RISC catalytic component 2 — RefSeq protein ID (P637): XP_011515268. Q20641742. Retrieved 2020-05-30. wikidata.org.
[24] ↑ Argonaute RISC catalytic component 2 — RefSeq protein ID (P637): XP_011515270. Q20641742. Retrieved 2020-05-30. wikidata.org.
[25] ↑ Argonaute RISC catalytic component 2 — RefSeq protein ID (P637): XP_016868806. Q20641742. Retrieved 2020-05-30. wikidata.org.
[26] ↑ Argonaute RISC catalytic component 2 — PDB structure ID (P638): 3LUC. Q905695. Retrieved 2016-08-09. wikidata.org.

Class ancestry

[1] ↑ Argonaute RISC catalytic component 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Argonaute RISC catalytic component 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/argonaute-risc-catalytic-component-2

MLA

“Argonaute RISC catalytic component 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/argonaute-risc-catalytic-component-2.

BibTeX

@misc{4ortxyz_argonaute-risc-catalytic-component-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Argonaute RISC catalytic component 2}}, year = {2026}, url = {https://4ort.xyz/entity/argonaute-risc-catalytic-component-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Argonaute RISC catalytic component 2 — https://4ort.xyz/entity/argonaute-risc-catalytic-component-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/argonaute-risc-catalytic-component-2 · Last refreshed: May 3, 2026