Apoptosis inducing factor mitochondria associated 1

mammalian protein found in Homo sapiens

Protein protein Q21116445

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Apoptosis inducing factor mitochondria associated 1

Summary

Apoptosis inducing factor mitochondria associated 1 is a protein^[1].

Key Facts

Apoptosis inducing factor mitochondria associated 1's instance of is recorded as protein^[2].
Apoptosis inducing factor mitochondria associated 1's UniProt protein ID is recorded as O95831^[3].
Apoptosis inducing factor mitochondria associated 1's part of is recorded as FAD/NAD-linked reductase, dimerisation domain superfamily^[4].
Apoptosis inducing factor mitochondria associated 1's part of is recorded as FAD/NAD(P)-binding domain superfamily^[5].
Apoptosis inducing factor mitochondria associated 1's part of is recorded as FAD/NAD(P)-binding domain, protein family^[6].
Apoptosis inducing factor mitochondria associated 1's part of is recorded as Mitochondrial apoptosis-inducing factor, C-terminal domain, protein family^[7].
Apoptosis inducing factor mitochondria associated 1's has part is recorded as FAD/NAD(P)-binding domain^[8].
Apoptosis inducing factor mitochondria associated 1's has part is recorded as Mitochondrial apoptosis-inducing factor, C-terminal domain^[9].
Apoptosis inducing factor mitochondria associated 1's RefSeq protein ID is recorded as NP_001124318^[10].
Apoptosis inducing factor mitochondria associated 1's RefSeq protein ID is recorded as NP_001124319^[11].
Apoptosis inducing factor mitochondria associated 1's RefSeq protein ID is recorded as NP_004199^[12].
Apoptosis inducing factor mitochondria associated 1's RefSeq protein ID is recorded as NP_665811^[13].
Apoptosis inducing factor mitochondria associated 1's PDB structure ID is recorded as 1M6I^[14].
Apoptosis inducing factor mitochondria associated 1's PDB structure ID is recorded as 4BUR^[15].
Apoptosis inducing factor mitochondria associated 1's PDB structure ID is recorded as 4BV6^[16].
Apoptosis inducing factor mitochondria associated 1's PDB structure ID is recorded as 4FDC^[17].
Apoptosis inducing factor mitochondria associated 1's PDB structure ID is recorded as 4LII^[18].
Apoptosis inducing factor mitochondria associated 1's PDB structure ID is recorded as 5FS7^[19].
Apoptosis inducing factor mitochondria associated 1's PDB structure ID is recorded as 5FS9^[20].
Apoptosis inducing factor mitochondria associated 1's PDB structure ID is recorded as 5FS6^[21].
Apoptosis inducing factor mitochondria associated 1's PDB structure ID is recorded as 5FS8^[22].
Apoptosis inducing factor mitochondria associated 1's molecular function is recorded as protein binding^[23].
Apoptosis inducing factor mitochondria associated 1's molecular function is recorded as protein dimerization activity^[24].
Apoptosis inducing factor mitochondria associated 1's molecular function is recorded as oxidoreductase activity^[25].
Apoptosis inducing factor mitochondria associated 1's molecular function is recorded as flavin adenine dinucleotide binding^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Part of FAD/NAD-linked reductase, dimerisation domain superfamily, FAD/NAD(P)-binding domain superfamily, FAD/NAD(P)-binding domain, protein family, Mitochondrial apoptosis-inducing factor, C-terminal domain, protein family

Properties

Biological process neuron apoptotic process, response to ischemia, chromosome condensation, cellular response to oxygen-glucose deprivation, activation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of neuron apoptotic process, regulation of apoptotic DNA fragmentation, cellular response to hydrogen peroxide, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, positive regulation of apoptotic process, cellular response to nitric oxide, response to L-glutamate, positive regulation of cell death, mitochondrial respiratory chain complex I assembly, response to toxic substance, cellular response to estradiol stimulus, neuron differentiation, cellular response to aldosterone, apoptotic process

Cell component mitochondrial inner membrane, cytoplasm, cytosol, membrane, perinuclear region of cytoplasm, mitochondrial intermembrane space, mitochondrion, nucleus, mitochondrion, mitochondrial intermembrane space

Encoded by AIFM1

Found in taxon Homo sapiens

Has part(s) FAD/NAD(P)-binding domain, Mitochondrial apoptosis-inducing factor, C-terminal domain

Imported from wholeness_audit_2026-05-02

Molecular function protein binding, protein dimerization activity, oxidoreductase activity, flavin adenine dinucleotide binding, NAD(P)H oxidase H2O2-forming activity, FAD binding, oxidoreductase activity, acting on NAD(P)H, DNA binding

External References (4)

Ensembl protein id ENSP00000287295, ENSP00000315122, ENSP00000316320, ENSP00000402535, ENSP00000446113, ENSP00000431222, ENSP00000432998, ENSP00000435955

Pdb structure id 1M6I, 4BUR, 4BV6, 4FDC, 4LII, 5FS7, 5FS9, 5FS6, 5FS8

Refseq protein id NP_001124318, NP_001124319, NP_004199, NP_665811

Uniprot protein id O95831

🏷️ Also known as

en AIFM1 en apoptosis-inducing factor 1, mitochondrial en Apoptosis inducing factor mitochondria associated 1 en apoptosis-inducing factor, mitochondrion-associated, 1 en auditory neuropathy, X-linked recessive 1 en programmed cell death 8 (apoptosis-inducing factor) en Programmed cell death protein 8 en striatal apoptosis-inducing factor en testicular secretory protein Li 4

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Apoptosis inducing factor mitochondria associated 1 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Apoptosis inducing factor mitochondria associated 1 — UniProt protein ID (P352): O95831. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Apoptosis inducing factor mitochondria associated 1 — part of (P361): FAD/NAD-linked reductase, dimerisation domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Apoptosis inducing factor mitochondria associated 1 — part of (P361): FAD/NAD(P)-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Apoptosis inducing factor mitochondria associated 1 — part of (P361): FAD/NAD(P)-binding domain, protein family. wikidata.org.
[7] ↑ Apoptosis inducing factor mitochondria associated 1 — part of (P361): Mitochondrial apoptosis-inducing factor, C-terminal domain, protein family. wikidata.org.
[8] ↑ Apoptosis inducing factor mitochondria associated 1 — has part(s) (P527): FAD/NAD(P)-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Apoptosis inducing factor mitochondria associated 1 — has part(s) (P527): Mitochondrial apoptosis-inducing factor, C-terminal domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Apoptosis inducing factor mitochondria associated 1 — RefSeq protein ID (P637): NP_001124318. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ Apoptosis inducing factor mitochondria associated 1 — RefSeq protein ID (P637): NP_001124319. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ Apoptosis inducing factor mitochondria associated 1 — RefSeq protein ID (P637): NP_004199. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ Apoptosis inducing factor mitochondria associated 1 — RefSeq protein ID (P637): NP_665811. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Apoptosis inducing factor mitochondria associated 1 — PDB structure ID (P638): 1M6I. Q905695. Retrieved 2016-08-09. wikidata.org.
[15] ↑ Apoptosis inducing factor mitochondria associated 1 — PDB structure ID (P638): 4BUR. Q905695. Retrieved 2016-08-09. wikidata.org.
[16] ↑ Apoptosis inducing factor mitochondria associated 1 — PDB structure ID (P638): 4BV6. Q905695. Retrieved 2016-08-09. wikidata.org.
[17] ↑ Apoptosis inducing factor mitochondria associated 1 — PDB structure ID (P638): 4FDC. Q905695. Retrieved 2016-08-09. wikidata.org.
[18] ↑ Apoptosis inducing factor mitochondria associated 1 — PDB structure ID (P638): 4LII. Q905695. Retrieved 2016-08-09. wikidata.org.
[19] ↑ Apoptosis inducing factor mitochondria associated 1 — PDB structure ID (P638): 5FS7. Q905695. Retrieved 2016-08-09. wikidata.org.
[20] ↑ Apoptosis inducing factor mitochondria associated 1 — PDB structure ID (P638): 5FS9. Q905695. Retrieved 2016-08-09. wikidata.org.
[21] ↑ Apoptosis inducing factor mitochondria associated 1 — PDB structure ID (P638): 5FS6. Q905695. Retrieved 2016-08-09. wikidata.org.
[22] ↑ Apoptosis inducing factor mitochondria associated 1 — PDB structure ID (P638): 5FS8. Q905695. Retrieved 2016-08-09. wikidata.org.
[23] ↑ Apoptosis inducing factor mitochondria associated 1 — molecular function (P680): protein binding. Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g). Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Apoptosis inducing factor mitochondria associated 1 — molecular function (P680): protein dimerization activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Apoptosis inducing factor mitochondria associated 1 — molecular function (P680): oxidoreductase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Apoptosis inducing factor mitochondria associated 1 — molecular function (P680): flavin adenine dinucleotide binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Apoptosis inducing factor mitochondria associated 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Apoptosis inducing factor mitochondria associated 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/apoptosis-inducing-factor-mitochondria-associated-1

MLA

“Apoptosis inducing factor mitochondria associated 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/apoptosis-inducing-factor-mitochondria-associated-1.

BibTeX

@misc{4ortxyz_apoptosis-inducing-factor-mitochondria-associated-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Apoptosis inducing factor mitochondria associated 1}}, year = {2026}, url = {https://4ort.xyz/entity/apoptosis-inducing-factor-mitochondria-associated-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Apoptosis inducing factor mitochondria associated 1 — https://4ort.xyz/entity/apoptosis-inducing-factor-mitochondria-associated-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/apoptosis-inducing-factor-mitochondria-associated-1 · Last refreshed: May 3, 2026