Annexin A1

mammalian protein found in Homo sapiens

Protein protein Q4769148

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Annexin A1

Summary

Annexin A1 is a protein^[1].

Key Facts

Annexin A1's instance of is recorded as protein^[2].
Annexin A1's UniProt protein ID is recorded as P04083^[3].
Annexin A1's part of is recorded as Annexin A1^[4].
Annexin A1's part of is recorded as Annexin superfamily^[5].
Annexin A1's part of is recorded as Annexin^[6].
Annexin A1's part of is recorded as Annexin repeat, conserved site, protein family^[7].
Annexin A1's part of is recorded as Annexin repeat, protein family^[8].
Annexin A1's has part is recorded as Annexin repeat, conserved site^[9].
Annexin A1's has part is recorded as Annexin repeat^[10].
Annexin A1's RefSeq protein ID is recorded as NP_000691^[11].
Annexin A1's RefSeq protein ID is recorded as XP_011516911^[12].
Annexin A1's RefSeq protein ID is recorded as XP_016870146^[13].
Annexin A1's PDB structure ID is recorded as 1QLS^[14].
Annexin A1's PDB structure ID is recorded as 1AIN^[15].
Annexin A1's PDB structure ID is recorded as 1BO9^[16].
Annexin A1's molecular function is recorded as calcium ion binding^[17].
Annexin A1's molecular function is recorded as protein-macromolecule adaptor activity^[18].
Annexin A1's molecular function is recorded as structural molecule activity^[19].
Annexin A1's molecular function is recorded as calcium-dependent protein binding^[20].
Annexin A1's molecular function is recorded as double-stranded DNA helicase activity^[21].
Annexin A1's molecular function is recorded as signaling receptor binding^[22].
Annexin A1's molecular function is recorded as phospholipid binding^[23].
Annexin A1's molecular function is recorded as ATP-dependent DNA/DNA annealing activity^[24].
Annexin A1's molecular function is recorded as helicase activity^[25].
Annexin A1's molecular function is recorded as phospholipase A2 inhibitor activity^[26].

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Quick Facts

Instance of protein

Part of Annexin A1, Annexin superfamily, Annexin, Annexin repeat, conserved site, protein family, Annexin repeat, protein family

Properties

Biological process response to interleukin-1, adaptive immune response, estrous cycle, hepatocyte differentiation, prostate gland development, cell surface receptor signaling pathway, myoblast migration involved in skeletal muscle regeneration, granulocyte chemotaxis, endocrine pancreas development, gliogenesis, negative regulation of T-helper 2 cell differentiation, neutrophil homeostasis, prolactin secretion, positive regulation of wound healing, negative regulation of phospholipase A2 activity, insulin secretion, regulation of leukocyte migration, positive regulation of G1/S transition of mitotic cell cycle, cellular response to glucocorticoid stimulus, positive regulation of T cell proliferation, phagocytosis, innate immune response, inflammatory response, arachidonic acid secretion, negative regulation of exocytosis, monocyte chemotaxis, immune system process, positive regulation of T-helper 1 cell differentiation, regulation of interleukin-1 production, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, negative regulation of apoptotic process, positive regulation of prostaglandin biosynthetic process, positive regulation of vesicle fusion, positive regulation of interleukin-2 production, regulation of inflammatory response, regulation of cell shape, alpha-beta T cell differentiation, response to hormone, actin cytoskeleton reorganization, response to estradiol, response to organic cyclic compound, response to peptide hormone, response to glucocorticoid, keratinocyte differentiation, positive regulation of neutrophil apoptotic process, DNA rewinding, response to corticosteroid, DNA duplex unwinding, peptide cross-linking, regulation of cell population proliferation, neutrophil clearance, positive regulation of apoptotic process, regulation of hormone secretion, negative regulation of protein secretion, response to X-ray, signal transduction, cellular response to hydrogen peroxide, cell-cell adhesion, G protein-coupled receptor signaling pathway, monocyte chemotaxis, regulation of leukocyte migration, phagocytosis, inflammatory response, cell surface receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, regulation of cell shape, response to X-ray, myoblast migration involved in skeletal muscle regeneration, cytokine-mediated signaling pathway, insulin secretion, keratinocyte differentiation, prostate gland development, endocrine pancreas development, positive regulation of vesicle fusion, positive regulation of prostaglandin biosynthetic process, actin cytoskeleton reorganization, response to estradiol, DNA duplex unwinding, regulation of interleukin-1 production, positive regulation of interleukin-2 production, positive regulation of neutrophil apoptotic process, cellular response to vascular endothelial growth factor stimulus, gliogenesis, positive regulation of T cell proliferation, regulation of cell population proliferation, response to peptide hormone, estrous cycle, positive regulation of T-helper 1 cell differentiation, negative regulation of T-helper 2 cell differentiation, negative regulation of exocytosis, alpha-beta T cell differentiation, regulation of hormone secretion, arachidonic acid secretion, regulation of inflammatory response, cellular response to hydrogen peroxide, hepatocyte differentiation, prolactin secretion, response to interleukin-1, cellular response to glucocorticoid stimulus, granulocyte chemotaxis, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of wound healing, neutrophil clearance, positive regulation of G1/S transition of mitotic cell cycle, negative regulation of phospholipase A2 activity

Cell component cytoplasm, endosome, membrane, focal adhesion, extracellular region, nucleus, cell projection, mitochondrial membranes, cilium, cornified envelope, cell surface, extrinsic component of external side of plasma membrane, apical plasma membrane, motile cilium, extracellular exosome, early endosome membrane, lateral plasma membrane, plasma membrane, extrinsic component of endosome membrane, nucleoplasm, early endosome, endosome membrane, extrinsic component of membrane, vesicle, mast cell granule, basolateral plasma membrane, sarcolemma, phagocytic cup, cytoplasmic vesicle membrane, cytoplasmic vesicle, extracellular space, cytosol, extracellular space, actin filament, plasma membrane, focal adhesion, vesicle, protein-containing complex, collagen-containing extracellular matrix, extracellular exosome, synaptic membrane

Encoded by ANXA1

Found in taxon Homo sapiens

Has part(s) Annexin repeat, conserved site, Annexin repeat

Imported from wholeness_audit_2026-05-02

Molecular function calcium ion binding, protein-macromolecule adaptor activity, structural molecule activity, calcium-dependent protein binding, double-stranded DNA helicase activity, signaling receptor binding, phospholipid binding, ATP-dependent DNA/DNA annealing activity, helicase activity, phospholipase A2 inhibitor activity, metal ion binding, protein homodimerization activity, single-stranded DNA binding, protein binding, calcium-dependent phospholipid binding, phospholipase inhibitor activity, single-stranded RNA binding, cadherin binding involved in cell-cell adhesion, single-stranded DNA binding, single-stranded RNA binding, structural molecule activity, calcium-dependent phospholipid binding, phospholipase A2 inhibitor activity, protein-macromolecule adaptor activity, double-stranded DNA helicase activity, protein homodimerization activity, calcium-dependent protein binding, cadherin binding involved in cell-cell adhesion, DNA/DNA annealing activity, structural molecule activity, protein-macromolecule adaptor activity

External References (6)

Ensembl protein id ENSP00000366109, ENSP00000257497, ENSP00000412489, ENSP00000414013

Pdb structure id 1QLS, 1AIN, 1BO9

Refseq protein id NP_000691, XP_011516911, XP_016870146

Sciencedirect topic id agricultural-and-biological-sciences/annexin-a1

Transporter classification database id 1.A.31.1.3

Uniprot protein id P04083

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Annexin A1 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Annexin A1 — UniProt protein ID (P352): P04083. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Annexin A1 — part of (P361): Annexin A1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Annexin A1 — part of (P361): Annexin superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Annexin A1 — part of (P361): Annexin. Retrieved 2019-10-02. wikidata.org.
[7] ↑ Annexin A1 — part of (P361): Annexin repeat, conserved site, protein family. wikidata.org.
[8] ↑ Annexin A1 — part of (P361): Annexin repeat, protein family. wikidata.org.
[9] ↑ Annexin A1 — has part(s) (P527): Annexin repeat, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Annexin A1 — has part(s) (P527): Annexin repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Annexin A1 — RefSeq protein ID (P637): NP_000691. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ Annexin A1 — RefSeq protein ID (P637): XP_011516911. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ Annexin A1 — RefSeq protein ID (P637): XP_016870146. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Annexin A1 — PDB structure ID (P638): 1QLS. Q905695. Retrieved 2016-08-09. wikidata.org.
[15] ↑ Annexin A1 — PDB structure ID (P638): 1AIN. Q905695. Retrieved 2016-08-09. wikidata.org.
[16] ↑ Annexin A1 — PDB structure ID (P638): 1BO9. Q905695. Retrieved 2016-08-09. wikidata.org.
[17] ↑ Annexin A1 — molecular function (P680): calcium ion binding. Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Annexin A1 — molecular function (P680): protein-macromolecule adaptor activity. Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Annexin A1 — molecular function (P680): structural molecule activity. Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Annexin A1 — molecular function (P680): calcium-dependent protein binding. Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Annexin A1 — molecular function (P680): double-stranded DNA helicase activity. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Annexin A1 — molecular function (P680): signaling receptor binding. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Annexin A1 — molecular function (P680): phospholipid binding. Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Annexin A1 — molecular function (P680): ATP-dependent DNA/DNA annealing activity. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Annexin A1 — molecular function (P680): helicase activity. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Annexin A1 — molecular function (P680): phospholipase A2 inhibitor activity. GOA. Retrieved 2017-10-31. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Annexin A1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Annexin A1. Retrieved May 3, 2026, from https://4ort.xyz/entity/annexin-a1-q4769148

MLA “Annexin A1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/annexin-a1-q4769148.

BibTeX

@misc{4ortxyz_annexin-a1-q4769148_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Annexin A1}}, year = {2026}, url = {https://4ort.xyz/entity/annexin-a1-q4769148}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Annexin A1 — https://4ort.xyz/entity/annexin-a1-q4769148 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/annexin-a1-q4769148 · Last refreshed: May 3, 2026