Alkaline ceramidase 1

mammalian protein found in Homo sapiens
Protein protein Q21172630
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Summary

Alkaline ceramidase 1 is a protein[1]. It is known by 8 alternative names across languages and contexts.[2]

Key Facts

  • Part of: ceramidase[3], membrane protein[4]
  • Molecular function: dihydroceramidase activity[5], hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides[6], hydrolase activity[7], N-acylsphingosine amidohydrolase activity[8], ceramidase activity[9], metal ion binding[10]
  • Cell component: membrane[11], integral component of membrane[12], endoplasmic reticulum membrane[13], endoplasmic reticulum[14]
  • Biological process: cellular response to calcium ion[15], regulation of lipid metabolic process[16], cell differentiation[17], sphingosine biosynthetic process[18], sphingolipid biosynthetic process[19], response to alkaline pH[20], keratinocyte differentiation[21], ceramide metabolic process[22], epidermis development[23], lipid metabolism[24], ceramide catabolic process[25], sphingolipid metabolic process[26], regulation of water loss via skin[27], sebaceous gland development[28]
  • Encoded by: ACER1[29]
  • Found in taxon: Homo sapiens[30]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . wikidata.org.
  3. [5] ↑ . Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  5. [7] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . UniProt. Retrieved . wikidata.org.
  28. [30] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Alkaline ceramidase 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/alkaline-ceramidase-1-q21172630
MLA “Alkaline ceramidase 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/alkaline-ceramidase-1-q21172630.
BibTeX @misc{4ortxyz_alkaline-ceramidase-1-q21172630_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Alkaline ceramidase 1}}, year = {2026}, url = {https://4ort.xyz/entity/alkaline-ceramidase-1-q21172630}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Alkaline ceramidase 1 — https://4ort.xyz/entity/alkaline-ceramidase-1-q21172630 (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 13w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → ACER1
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → dihydroceramidase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, hydrolase activity +4
    + 9 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 3.5.1.23, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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