Adenosine A1 receptor

mammalian protein found in Rattus norvegicus

Protein protein Q28557361

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Adenosine A1 receptor

Summary

Adenosine A1 receptor is a protein^[1].

Key Facts

Adenosine A1 receptor's instance of is recorded as protein^[2].
Adenosine A1 receptor's UniProt protein ID is recorded as P25099^[3].
Adenosine A1 receptor's part of is recorded as Adenosine A1 receptor^[4].
Adenosine A1 receptor's part of is recorded as membrane protein^[5].
Adenosine A1 receptor's part of is recorded as GPCR, rhodopsin-like, 7TM, protein family^[6].
Adenosine A1 receptor's has part is recorded as GPCR, rhodopsin-like, 7TM^[7].
Adenosine A1 receptor's RefSeq protein ID is recorded as NP_058851^[8].
Adenosine A1 receptor's RefSeq protein ID is recorded as XP_006249921^[9].
Adenosine A1 receptor's RefSeq protein ID is recorded as XP_006249923^[10].
Adenosine A1 receptor's RefSeq protein ID is recorded as XP_038946545^[11].
Adenosine A1 receptor's RefSeq protein ID is recorded as XP_038946546^[12].
Adenosine A1 receptor's RefSeq protein ID is recorded as XP_038946547^[13].
Adenosine A1 receptor's RefSeq protein ID is recorded as XP_038946548^[14].
Adenosine A1 receptor's molecular function is recorded as G protein-coupled adenosine receptor activity^[15].
Adenosine A1 receptor's molecular function is recorded as G protein-coupled receptor binding^[16].
Adenosine A1 receptor's molecular function is recorded as purine nucleoside binding^[17].
Adenosine A1 receptor's molecular function is recorded as G protein-coupled receptor activity^[18].
Adenosine A1 receptor's molecular function is recorded as protein binding^[19].
Adenosine A1 receptor's molecular function is recorded as heat shock protein binding^[20].
Adenosine A1 receptor's molecular function is recorded as G-protein beta/gamma-subunit complex binding^[21].
Adenosine A1 receptor's molecular function is recorded as heterotrimeric G-protein binding^[22].
Adenosine A1 receptor's molecular function is recorded as protein heterodimerization activity^[23].
Adenosine A1 receptor's molecular function is recorded as neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration^[24].
Adenosine A1 receptor's cell component is recorded as endoplasmic reticulum^[25].
Adenosine A1 receptor's cell component is recorded as plasma membrane^[26].

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Quick Facts

Instance of protein

Part of Adenosine A1 receptor, membrane protein, GPCR, rhodopsin-like, 7TM, protein family

Properties

Biological process temperature homeostasis, response to hypoxia, G protein-coupled adenosine receptor signaling pathway, regulation of respiratory gaseous exchange by nervous system process, negative regulation of acute inflammatory response, negative regulation of leukocyte migration, positive regulation of peptide secretion, positive regulation of systemic arterial blood pressure, negative regulation of systemic arterial blood pressure, regulation of glomerular filtration, protein targeting to membrane, signal transduction, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, negative regulation of cell population proliferation, negative regulation of glutamate secretion, lipid catabolic process, negative regulation of synaptic transmission, GABAergic, positive regulation of nucleoside transport, negative regulation of neurotrophin production, positive regulation of protein dephosphorylation, negative regulation of renal sodium excretion, negative regulation of circadian sleep/wake cycle, sleep, negative regulation of circadian sleep/wake cycle, non-REM sleep, negative regulation of apoptotic process, positive regulation of potassium ion transport, positive regulation of epidermal growth factor-activated receptor activity, negative regulation of blood pressure, positive regulation of blood pressure, negative regulation of heart contraction, negative regulation of hormone secretion, negative regulation of inflammatory response, cognition, detection of temperature stimulus involved in sensory perception of pain, negative regulation of lipid catabolic process, positive regulation of lipid catabolic process, regulation of sensory perception of pain, negative regulation of synaptic transmission, glutamatergic, fatty acid homeostasis, regulation of cardiac muscle contraction, excitatory postsynaptic potential, relaxation of vascular associated smooth muscle, negative regulation of mucus secretion, triglyceride homeostasis, regulation of cardiac muscle cell contraction, regulation of presynaptic cytosolic calcium ion concentration, negative regulation of long-term synaptic potentiation, negative regulation of long-term synaptic depression, positive regulation of neuron death

Cell component endoplasmic reticulum, plasma membrane, endomembrane system, postsynaptic density, membrane, integral component of membrane, basolateral plasma membrane, dendrite, axolemma, asymmetric synapse, presynaptic membrane, soma, terminal bouton, dendritic spine, cell body, calyx of Held, synapse, postsynaptic membrane, presynaptic active zone, integral component of postsynaptic membrane, integral component of presynaptic membrane

Encoded by Adora1

Found in taxon brown rat

Has part(s) GPCR, rhodopsin-like, 7TM

Imported from wholeness_audit_2026-05-02

Molecular function G protein-coupled adenosine receptor activity, G protein-coupled receptor binding, purine nucleoside binding, G protein-coupled receptor activity, protein binding, heat shock protein binding, G-protein beta/gamma-subunit complex binding, heterotrimeric G-protein binding, protein heterodimerization activity, neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration

External References (3)

Ensembl protein id ENSRNOP00000004602

Refseq protein id NP_058851, XP_006249921, XP_006249923, XP_038946545, XP_038946546, XP_038946547, XP_038946548

Uniprot protein id P25099

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Adenosine A1 receptor — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Adenosine A1 receptor — UniProt protein ID (P352): P25099. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Adenosine A1 receptor — part of (P361): Adenosine A1 receptor. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Adenosine A1 receptor — part of (P361): membrane protein. wikidata.org.
[6] ↑ Adenosine A1 receptor — part of (P361): GPCR, rhodopsin-like, 7TM, protein family. wikidata.org.
[7] ↑ Adenosine A1 receptor — has part(s) (P527): GPCR, rhodopsin-like, 7TM. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Adenosine A1 receptor — RefSeq protein ID (P637): NP_058851. Q20641742. Retrieved 2022-03-20. wikidata.org.
[9] ↑ Adenosine A1 receptor — RefSeq protein ID (P637): XP_006249921. Q20641742. Retrieved 2022-03-20. wikidata.org.
[10] ↑ Adenosine A1 receptor — RefSeq protein ID (P637): XP_006249923. Q20641742. Retrieved 2022-03-20. wikidata.org.
[11] ↑ Adenosine A1 receptor — RefSeq protein ID (P637): XP_038946545. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Adenosine A1 receptor — RefSeq protein ID (P637): XP_038946546. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Adenosine A1 receptor — RefSeq protein ID (P637): XP_038946547. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Adenosine A1 receptor — RefSeq protein ID (P637): XP_038946548. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Adenosine A1 receptor — molecular function (P680): G protein-coupled adenosine receptor activity. Adenosine A1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Adenosine A1 receptor — molecular function (P680): G protein-coupled receptor binding. Heteromeric association creates a P2Y-like adenosine receptor. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Adenosine A1 receptor — molecular function (P680): purine nucleoside binding. Tonic activity of the rat adipocyte A1-adenosine receptor. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Adenosine A1 receptor — molecular function (P680): G protein-coupled receptor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Adenosine A1 receptor — molecular function (P680): protein binding. Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Adenosine A1 receptor — molecular function (P680): heat shock protein binding. The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Adenosine A1 receptor — molecular function (P680): G-protein beta/gamma-subunit complex binding. Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Adenosine A1 receptor — molecular function (P680): heterotrimeric G-protein binding. Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Adenosine A1 receptor — molecular function (P680): protein heterodimerization activity. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Adenosine A1 receptor — molecular function (P680): neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration. Adenosine A(1) receptor-mediated presynaptic inhibition at the calyx of Held of immature rats.. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Adenosine A1 receptor — cell component (P681): endoplasmic reticulum. Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Adenosine A1 receptor — cell component (P681): plasma membrane. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Adenosine A1 receptor is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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