Activating transcription factor 2

mammalian protein found in Homo sapiens

Protein protein Q21116768

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Summary

Activating transcription factor 2 is a protein^[1].

Key Facts

Activating transcription factor 2's instance of is recorded as protein^[2].
Activating transcription factor 2's UniProt protein ID is recorded as P15336^[3].
Activating transcription factor 2's part of is recorded as cAMP-dependent transcription factor ATF-2^[4].
Activating transcription factor 2's part of is recorded as Zinc finger C2H2 superfamily^[5].
Activating transcription factor 2's part of is recorded as Basic-leucine zipper domain, protein family^[6].
Activating transcription factor 2's part of is recorded as Zinc finger C2H2-type, protein family^[7].
Activating transcription factor 2's MeSH descriptor ID is recorded as D051698^[8].
Activating transcription factor 2's has part is recorded as Zinc finger C2H2-type^[9].
Activating transcription factor 2's has part is recorded as Basic-leucine zipper domain^[10].
Activating transcription factor 2's RefSeq protein ID is recorded as NP_001243019^[11].
Activating transcription factor 2's RefSeq protein ID is recorded as NP_001243020^[12].
Activating transcription factor 2's RefSeq protein ID is recorded as NP_001243021^[13].
Activating transcription factor 2's RefSeq protein ID is recorded as NP_001243022^[14].
Activating transcription factor 2's RefSeq protein ID is recorded as NP_001243023^[15].
Activating transcription factor 2's RefSeq protein ID is recorded as NP_001871^[16].
Activating transcription factor 2's PDB structure ID is recorded as 1BHI^[17].
Activating transcription factor 2's PDB structure ID is recorded as 1T2K^[18].
Activating transcription factor 2's PDB structure ID is recorded as 4H36^[19].
Activating transcription factor 2's MeSH tree code is recorded as D12.776.260.108.061.750^[20].
Activating transcription factor 2's MeSH tree code is recorded as D12.776.930.127.061.750^[21].
Activating transcription factor 2's molecular function is recorded as transferase activity^[22].
Activating transcription factor 2's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[23].
Activating transcription factor 2's molecular function is recorded as DNA binding^[24].
Activating transcription factor 2's molecular function is recorded as sequence-specific DNA binding^[25].
Activating transcription factor 2's molecular function is recorded as RNA polymerase II transcription regulatory region sequence-specific DNA binding^[26].

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Quick Facts

Instance of protein

Part of cAMP-dependent transcription factor ATF-2, Zinc finger C2H2 superfamily, Basic-leucine zipper domain, protein family, Zinc finger C2H2-type, protein family

Properties

Biological process regulation of transcription, DNA-templated, regulation of transcription by RNA polymerase II, mitotic intra-S DNA damage checkpoint signaling, outflow tract morphogenesis, response to water deprivation, positive regulation of DNA-binding transcription factor activity, negative regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, positive regulation of transforming growth factor beta2 production, transcription, DNA-templated, cellular response to DNA damage stimulus, response to osmotic stress, positive regulation of neuron apoptotic process, regulation of DNA-binding transcription factor activity, positive regulation of mitochondrial membrane permeability involved in apoptotic process, negative regulation of epithelial cell proliferation, adipose tissue development, fat cell differentiation, positive regulation of transcription by RNA polymerase II, amelogenesis, histone acetylation, positive regulation of cardiac muscle myoblast proliferation, positive regulation of gene expression, negative regulation of angiogenesis, regulation of transcription by RNA polymerase II

Cell component cytoplasm, membrane, nucleoplasm, mitochondrial outer membrane, mitochondrion, nucleus, site of double-strand break

Encoded by ATF2

Found in taxon Homo sapiens

Has part(s) Zinc finger C2H2-type, Basic-leucine zipper domain

Imported from wholeness_audit_2026-05-02

Molecular function transferase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA binding, sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, cAMP response element binding protein binding, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription coactivator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, chromatin binding, metal ion binding, protein binding, cis-regulatory region sequence-specific DNA binding, nucleic acid binding, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, protein kinase binding, cAMP response element binding, histone acetyltransferase activity, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription factor binding, protein heterodimerization activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription activator activity, RNA polymerase II-specific, histone acetyltransferase activity

External References (7)

Ensembl protein id ENSP00000264110, ENSP00000340576, ENSP00000376327, ENSP00000386282, ENSP00000386526, ENSP00000387093, ENSP00000407911, ENSP00000386326, ENSP00000389504, ENSP00000402190, ENSP00000402229, ENSP00000406995, ENSP00000410086, ENSP00000410224, ENSP00000412293, ENSP00000414171, ENSP00000416854, ENSP00000437952

Mesh descriptor id D051698

Mesh tree code D12.776.260.108.061.750, D12.776.930.127.061.750

Pdb structure id 1BHI, 1T2K, 4H36

Refseq protein id NP_001243019, NP_001243020, NP_001243021, NP_001243022, NP_001243023, NP_001871

Umls cui C1578927

Uniprot protein id P15336

🏷️ Also known as

en Activating transcription factor 2 en activating transcription factor 2 splice variant ATF2-var2 en ATF2 en cAMP-dependent transcription factor ATF-2 en cAMP response element-binding protein CRE-BP1 en cAMP-responsive element-binding protein 2 en cAMP responsive element binding protein 2, formerly en CREB-2 en cyclic AMP-dependent transcription factor ATF-2 en cyclic AMP-responsive element-binding protein 2 en HB16 en histone acetyltransferase ATF2

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Activating transcription factor 2 — instance of (P31): protein. UniProt. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Activating transcription factor 2 — UniProt protein ID (P352): P15336. UniProt. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Activating transcription factor 2 — part of (P361): cAMP-dependent transcription factor ATF-2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Activating transcription factor 2 — part of (P361): Zinc finger C2H2 superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Activating transcription factor 2 — part of (P361): Basic-leucine zipper domain, protein family. wikidata.org.
[7] ↑ Activating transcription factor 2 — part of (P361): Zinc finger C2H2-type, protein family. wikidata.org.
[8] ↑ Activating transcription factor 2 — MeSH descriptor ID (P486): D051698. wikidata.org.
[9] ↑ Activating transcription factor 2 — has part(s) (P527): Zinc finger C2H2-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Activating transcription factor 2 — has part(s) (P527): Basic-leucine zipper domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Activating transcription factor 2 — RefSeq protein ID (P637): NP_001243019. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ Activating transcription factor 2 — RefSeq protein ID (P637): NP_001243020. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ Activating transcription factor 2 — RefSeq protein ID (P637): NP_001243021. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Activating transcription factor 2 — RefSeq protein ID (P637): NP_001243022. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ Activating transcription factor 2 — RefSeq protein ID (P637): NP_001243023. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ Activating transcription factor 2 — RefSeq protein ID (P637): NP_001871. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ Activating transcription factor 2 — PDB structure ID (P638): 1BHI. UniProt. Retrieved 2016-08-04. wikidata.org.
[18] ↑ Activating transcription factor 2 — PDB structure ID (P638): 1T2K. UniProt. Retrieved 2016-08-04. wikidata.org.
[19] ↑ Activating transcription factor 2 — PDB structure ID (P638): 4H36. UniProt. Retrieved 2016-08-04. wikidata.org.
[20] ↑ Activating transcription factor 2 — MeSH tree code (P672): D12.776.260.108.061.750. wikidata.org.
[21] ↑ Activating transcription factor 2 — MeSH tree code (P672): D12.776.930.127.061.750. wikidata.org.
[22] ↑ Activating transcription factor 2 — molecular function (P680): transferase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Activating transcription factor 2 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. cJun modulates Ggamma-globin gene expression via an upstream cAMP response element. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Activating transcription factor 2 — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Activating transcription factor 2 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Activating transcription factor 2 — molecular function (P680): RNA polymerase II transcription regulatory region sequence-specific DNA binding. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Activating transcription factor 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_activating-transcription-factor-2-q21116768_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Activating transcription factor 2}}, year = {2026}, url = {https://4ort.xyz/entity/activating-transcription-factor-2-q21116768}, note = {Accessed: 2026-05-03}}

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