Home › Entities › cysteine loop ligand-gated ion channel receptor › 5-hydroxytryptamine receptor 3A

5-hydroxytryptamine receptor 3A

mammalian protein found in Homo sapiens
Class type of: cysteine loop ligand-gated ion channel receptor Q21108125

Facts

10 properties
Instance of
protein
Subclass of
cysteine loop ligand-gated ion channel receptor[20]
Part of
Neurotransmitter-gated ion-channel ligand-binding domain superfamily, Neurotransmitter-gated ion-channel transmembrane domain superfamily, 5-hydroxytryptamine 3 receptor, A subunit, cysteine loop ligand-gated ion channel receptor, Neurotransmitter-gated ion-channel transmembrane domain, protein family, Neurotransmitter-gated ion-channel ligand-binding domain, protein family, Neurotransmitter-gated ion-channel, conserved site, protein family[21][22][23][24]
Biological process
response to cocaine, cellular response to growth factor stimulus, ion transport, response to ethanol, positive regulation of ion transmembrane transporter activity, signal transduction, ion transmembrane transport, serotonin receptor signaling pathway, signal transduction, chemical synaptic transmission, ion transmembrane transport, regulation of membrane potential, nervous system process, chemical synaptic transmission
Cell component
cytoplasm, integral component of membrane, postsynaptic membrane, membrane, plasma membrane, synapse, axon, cell junction, soma, serotonin-activated cation-selective channel complex, cleavage furrow, glutamatergic synapse, integral component of postsynaptic membrane, integral component of presynaptic membrane, integral component of plasma membrane, neuron projection, synapse
Encoded by
HTR3A
Found in taxon
Homo sapiens
Has part(s)
Neurotransmitter-gated ion-channel transmembrane domain, Neurotransmitter-gated ion-channel ligand-binding domain, Neurotransmitter-gated ion-channel, conserved site
Molecular function
protein binding, ligand-gated ion channel activity, serotonin binding, extracellular ligand-gated ion channel activity, serotonin-gated cation-selective channel activity, ion channel activity, transmembrane signaling receptor activity, extracellular ligand-gated ion channel activity
Physically interacts with
2-methyl-5-HT, serotonin, 1-(3-chlorophenyl)biguanide, quipazine, alosetron, azasetron, cilansetron, cocaine, metoclopramide, ondansetron, ramosetron, tubocurarine, vortioxetine, bilobalide, diltiazem, dolasetron, zimelidine, metoclopramide hydrochloride hydrate[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]
🏷️ Also known as
en 5-HT-3 en 5-HT3-A en 5-HT3R en 5HT3 serotonin receptor en 5-hydroxytryptamine receptor 3 en 5-hydroxytryptamine receptor 3A en 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic en HTR3A en serotonin-gated ion channel receptor en serotonin receptor 3A
🔖 Identifiers · 6
Ensembl protein ID
ENSP00000299961, ENSP00000347754, ENSP00000364648, ENSP00000424189, ENSP00000424776, ENSP00000423653
Exact match
identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov
PDB structure ID
4PIR
RefSeq protein ID
NP_000860, NP_001155244, NP_998786
Transporter Classification Database ID
1.A.9.2.1
UniProt protein ID
P46098

Report an error or request removal Lineage (PROV-JSON)

Press Enter · cited answer in seconds

Summary

5-hydroxytryptamine receptor 3A is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  2. [3] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  3. [4] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  4. [5] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  5. [6] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  6. [7] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  7. [8] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  8. [9] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  9. [10] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  10. [11] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  11. [12] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  12. [13] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  13. [14] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  14. [15] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  15. [16] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  16. [17] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  17. [18] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  18. [19] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  19. [20] ↑ . Retrieved . wikidata.org.
  20. [21] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). 5-hydroxytryptamine receptor 3A. Retrieved May 3, 2026, from https://4ort.xyz/entity/5-hydroxytryptamine-receptor-3a
MLA “5-hydroxytryptamine receptor 3A.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/5-hydroxytryptamine-receptor-3a.
BibTeX @misc{4ortxyz_5-hydroxytryptamine-receptor-3a_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{5-hydroxytryptamine receptor 3A}}, year = {2026}, url = {https://4ort.xyz/entity/5-hydroxytryptamine-receptor-3a}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): 5-hydroxytryptamine receptor 3A — https://4ort.xyz/entity/5-hydroxytryptamine-receptor-3a (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/5-hydroxytryptamine-receptor-3a · Last refreshed: