3-hydroxy-3-methylglutaryl-Coenzyme A reductase

mammalian protein found in Mus musculus

Protein protein Q14864142

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3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Summary

3-hydroxy-3-methylglutaryl-Coenzyme A reductase is a protein^[1].

Key Facts

3-hydroxy-3-methylglutaryl-Coenzyme A reductase's instance of is recorded as protein^[2].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's physically interacts with is recorded as lovastatin^[3].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's UniProt protein ID is recorded as Q01237^[4].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, metazoan^[5].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily^[6].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily^[7].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, N-terminal^[8].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily^[9].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's part of is recorded as membrane protein^[10].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's part of is recorded as Sterol-sensing domain, protein family^[11].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family^[12].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's has part is recorded as Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site^[13].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's has part is recorded as Sterol-sensing domain^[14].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's RefSeq protein ID is recorded as NP_032281^[15].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's RefSeq protein ID is recorded as NP_001347094^[16].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's RefSeq protein ID is recorded as NP_001347095^[17].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's RefSeq protein ID is recorded as XP_036013747^[18].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's molecular function is recorded as oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor^[19].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's molecular function is recorded as hydroxymethylglutaryl-CoA reductase (NADPH) activity^[20].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's molecular function is recorded as NADP binding^[21].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's molecular function is recorded as NADPH binding^[22].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's molecular function is recorded as oxidoreductase activity^[23].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's molecular function is recorded as protein homodimerization activity^[24].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's molecular function is recorded as protein phosphatase 2A binding^[25].
3-hydroxy-3-methylglutaryl-Coenzyme A reductase's molecular function is recorded as hydroxymethylglutaryl-CoA reductase (NADPH) activity^[26].

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Quick Facts

Instance of protein

Part of Hydroxymethylglutaryl-CoA reductase, metazoan, Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily, Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily, Hydroxymethylglutaryl-CoA reductase, N-terminal, Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily, membrane protein, Sterol-sensing domain, protein family, Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family

Properties

Biological process visual learning, steroid metabolic process, sterol biosynthetic process, coenzyme A metabolic process, lipid metabolism, response to nutrient, ageing, cholesterol metabolic process, protein tetramerization, negative regulation of MAP kinase activity, cholesterol biosynthetic process, myoblast differentiation, response to ethanol, steroid biosynthetic process, ubiquinone metabolic process, positive regulation of cell population proliferation, isoprenoid biosynthetic process, negative regulation of striated muscle cell apoptotic process, positive regulation of cardiac muscle cell apoptotic process, positive regulation of stress-activated MAPK cascade, negative regulation of apoptotic process, positive regulation of skeletal muscle tissue development, positive regulation of smooth muscle cell proliferation, negative regulation of wound healing, negative regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of ERK1 and ERK2 cascade, sterol biosynthetic process, negative regulation of protein catabolic process, negative regulation of protein secretion, negative regulation of amyloid-beta clearance

Cell component integral component of membrane, endoplasmic reticulum membrane, membrane, peroxisomal membrane, endoplasmic reticulum, intracellular membrane-bounded organelle

Encoded by Hmgcr

Found in taxon house mouse

Has part(s) Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, Sterol-sensing domain

Imported from wholeness_audit_2026-05-02

Molecular function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, hydroxymethylglutaryl-CoA reductase (NADPH) activity, NADP binding, NADPH binding, oxidoreductase activity, protein homodimerization activity, protein phosphatase 2A binding, hydroxymethylglutaryl-CoA reductase (NADPH) activity

Physically interacts with lovastatin

External References (3)

Ensembl protein id ENSMUSP00000126087, ENSMUSP00000126959, ENSMUSP00000128294, ENSMUSP00000128642, ENSMUSP00000128939, ENSMUSP00000132155, ENSMUSP00000132749, ENSMUSP00000022176

Refseq protein id NP_032281, NP_001347094, NP_001347095, XP_036013747

Uniprot protein id Q01237

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — physically interacts with (P129): lovastatin. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — UniProt protein ID (P352): Q01237. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, metazoan. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — part of (P361): membrane protein. wikidata.org.
[11] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — part of (P361): Sterol-sensing domain, protein family. wikidata.org.
[12] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family. wikidata.org.
[13] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — has part(s) (P527): Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — has part(s) (P527): Sterol-sensing domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — RefSeq protein ID (P637): NP_032281. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — RefSeq protein ID (P637): NP_001347094. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — RefSeq protein ID (P637): NP_001347095. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — RefSeq protein ID (P637): XP_036013747. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — molecular function (P680): oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — molecular function (P680): hydroxymethylglutaryl-CoA reductase (NADPH) activity. GOA. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — molecular function (P680): NADP binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — molecular function (P680): NADPH binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — molecular function (P680): oxidoreductase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — molecular function (P680): protein homodimerization activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — molecular function (P680): protein phosphatase 2A binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — molecular function (P680): hydroxymethylglutaryl-CoA reductase (NADPH) activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ 3-hydroxy-3-methylglutaryl-Coenzyme A reductase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“3-hydroxy-3-methylglutaryl-Coenzyme A reductase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-q14864142.

BibTeX

@misc{4ortxyz_3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-q14864142_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{3-hydroxy-3-methylglutaryl-Coenzyme A reductase}}, year = {2026}, url = {https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-q14864142}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): 3-hydroxy-3-methylglutaryl-Coenzyme A reductase — https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-q14864142 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-q14864142 · Last refreshed: May 3, 2026