3-hydroxy-3-methylglutaryl-CoA reductase

mammalian protein found in Rattus norvegicus

Protein protein Q28562064

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3-hydroxy-3-methylglutaryl-CoA reductase

Summary

3-hydroxy-3-methylglutaryl-CoA reductase is a protein^[1].

Key Facts

3-hydroxy-3-methylglutaryl-CoA reductase's instance of is recorded as protein^[2].
3-hydroxy-3-methylglutaryl-CoA reductase's UniProt protein ID is recorded as P51639^[3].
3-hydroxy-3-methylglutaryl-CoA reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, metazoan^[4].
3-hydroxy-3-methylglutaryl-CoA reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily^[5].
3-hydroxy-3-methylglutaryl-CoA reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily^[6].
3-hydroxy-3-methylglutaryl-CoA reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, N-terminal^[7].
3-hydroxy-3-methylglutaryl-CoA reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily^[8].
3-hydroxy-3-methylglutaryl-CoA reductase's part of is recorded as membrane protein^[9].
3-hydroxy-3-methylglutaryl-CoA reductase's part of is recorded as Sterol-sensing domain, protein family^[10].
3-hydroxy-3-methylglutaryl-CoA reductase's part of is recorded as Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family^[11].
3-hydroxy-3-methylglutaryl-CoA reductase's has part is recorded as Sterol-sensing domain^[12].
3-hydroxy-3-methylglutaryl-CoA reductase's has part is recorded as Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site^[13].
3-hydroxy-3-methylglutaryl-CoA reductase's RefSeq protein ID is recorded as NP_037266^[14].
3-hydroxy-3-methylglutaryl-CoA reductase's RefSeq protein ID is recorded as XP_006231888^[15].
3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as hydroxymethylglutaryl-CoA reductase (NADPH) activity^[16].
3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as oxidoreductase activity^[17].
3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor^[18].
3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as protein homodimerization activity^[19].
3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as NADP binding^[20].
3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as protein phosphatase 2A binding^[21].
3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as NADPH binding^[22].
3-hydroxy-3-methylglutaryl-CoA reductase's cell component is recorded as peroxisomal membrane^[23].
3-hydroxy-3-methylglutaryl-CoA reductase's cell component is recorded as endoplasmic reticulum^[24].
3-hydroxy-3-methylglutaryl-CoA reductase's cell component is recorded as endoplasmic reticulum membrane^[25].
3-hydroxy-3-methylglutaryl-CoA reductase's cell component is recorded as membrane^[26].

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Quick Facts

Instance of protein

Part of Hydroxymethylglutaryl-CoA reductase, metazoan, Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily, Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily, Hydroxymethylglutaryl-CoA reductase, N-terminal, Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily, membrane protein, Sterol-sensing domain, protein family, Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family

Properties

Biological process lipid metabolism, steroid biosynthetic process, cholesterol biosynthetic process, ubiquinone metabolic process, ageing, response to nutrient, steroid metabolic process, cholesterol metabolic process, positive regulation of cell population proliferation, isoprenoid biosynthetic process, visual learning, farnesyl diphosphate biosynthetic process, mevalonate pathway, negative regulation of striated muscle cell apoptotic process, positive regulation of cardiac muscle cell apoptotic process, coenzyme A metabolic process, sterol biosynthetic process, positive regulation of stress-activated MAPK cascade, negative regulation of protein catabolic process, negative regulation of apoptotic process, negative regulation of MAP kinase activity, myoblast differentiation, response to ethanol, positive regulation of skeletal muscle tissue development, positive regulation of smooth muscle cell proliferation, negative regulation of protein secretion, protein tetramerization, negative regulation of wound healing, negative regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of ERK1 and ERK2 cascade, negative regulation of amyloid-beta clearance

Cell component peroxisomal membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, integral component of membrane, intracellular membrane-bounded organelle

Encoded by Hmgcr

Found in taxon brown rat

Has part(s) Sterol-sensing domain, Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function hydroxymethylglutaryl-CoA reductase (NADPH) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein homodimerization activity, NADP binding, protein phosphatase 2A binding, NADPH binding

External References (3)

Ensembl protein id ENSRNOP00000022055

Refseq protein id NP_037266, XP_006231888

Uniprot protein id P51639

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — instance of (P31): protein. Q905695. Retrieved 2021-11-17. wikidata.org.
[3] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — UniProt protein ID (P352): P51639. Q905695. Retrieved 2021-11-17. wikidata.org.
[4] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, metazoan. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — part of (P361): membrane protein. wikidata.org.
[10] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — part of (P361): Sterol-sensing domain, protein family. wikidata.org.
[11] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — part of (P361): Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family. wikidata.org.
[12] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — has part(s) (P527): Sterol-sensing domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — has part(s) (P527): Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — RefSeq protein ID (P637): NP_037266. Q20641742. Retrieved 2021-09-07. wikidata.org.
[15] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — RefSeq protein ID (P637): XP_006231888. Q20641742. Retrieved 2021-09-07. wikidata.org.
[16] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — molecular function (P680): hydroxymethylglutaryl-CoA reductase (NADPH) activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — molecular function (P680): oxidoreductase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — molecular function (P680): oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — molecular function (P680): protein homodimerization activity. Functional size of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by radiation inactivation. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — molecular function (P680): NADP binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — molecular function (P680): protein phosphatase 2A binding. Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — molecular function (P680): NADPH binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — cell component (P681): peroxisomal membrane. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — cell component (P681): endoplasmic reticulum. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — cell component (P681): endoplasmic reticulum membrane. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase — cell component (P681): membrane. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ 3-hydroxy-3-methylglutaryl-CoA reductase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). 3-hydroxy-3-methylglutaryl-CoA reductase. Retrieved May 3, 2026, from https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coa-reductase-q28562064

MLA

“3-hydroxy-3-methylglutaryl-CoA reductase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coa-reductase-q28562064.

BibTeX

@misc{4ortxyz_3-hydroxy-3-methylglutaryl-coa-reductase-q28562064_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{3-hydroxy-3-methylglutaryl-CoA reductase}}, year = {2026}, url = {https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coa-reductase-q28562064}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): 3-hydroxy-3-methylglutaryl-CoA reductase — https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coa-reductase-q28562064 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coa-reductase-q28562064 · Last refreshed: May 3, 2026