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3-hydroxy-3-methylglutaryl-CoA reductase

mammalian protein found in Homo sapiens
Protein protein Q415607
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Summary

3-hydroxy-3-methylglutaryl-CoA reductase is a protein[1]. It has Wikipedia articles in 18 language editions, a strong signal of global cultural recognition.[2]

Key Facts

  • 3-hydroxy-3-methylglutaryl-CoA reductase's instance of is recorded as protein[3].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's physically interacts with is recorded as atorvastatin[4].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's physically interacts with is recorded as cerivastatin[5].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's physically interacts with is recorded as fluvastatin[6].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's physically interacts with is recorded as lovastatin[7].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's physically interacts with is recorded as mevastatin[8].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's physically interacts with is recorded as pravastatin[9].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's physically interacts with is recorded as rosuvastatin[10].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's physically interacts with is recorded as simvastatin[11].
  • 3-hydroxy-3-methylglutaryl-CoA reductase is part of Hydroxymethylglutaryl-CoA reductase, metazoan[12].
  • 3-hydroxy-3-methylglutaryl-CoA reductase is part of Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily[13].
  • 3-hydroxy-3-methylglutaryl-CoA reductase is part of Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily[14].
  • 3-hydroxy-3-methylglutaryl-CoA reductase is part of Hydroxymethylglutaryl-CoA reductase, N-terminal[15].
  • 3-hydroxy-3-methylglutaryl-CoA reductase is part of Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily[16].
  • 3-hydroxy-3-methylglutaryl-CoA reductase is part of Eukaryotic Sterol Transporter[17].
  • 3-hydroxy-3-methylglutaryl-CoA reductase is part of Sterol-sensing domain, protein family[18].
  • 3-hydroxy-3-methylglutaryl-CoA reductase is part of Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family[19].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's Commons category is recorded as HMG-CoA reductase[20].
  • 3-hydroxy-3-methylglutaryl-CoA reductase comprises Sterol-sensing domain[21].
  • 3-hydroxy-3-methylglutaryl-CoA reductase comprises Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site[22].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor[23].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as protein homodimerization activity[24].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as hydroxymethylglutaryl-CoA reductase (NADPH) activity[25].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as protein binding[26].
  • 3-hydroxy-3-methylglutaryl-CoA reductase's molecular function is recorded as NADP binding[27].

Why It Matters

3-hydroxy-3-methylglutaryl-CoA reductase has Wikipedia articles in 18 language editions, a strong signal of global cultural recognition.[2] It is known by 26 alternative names across languages and contexts.[28]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . UniProt. Retrieved . wikidata.org.
  2. [4] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  3. [5] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  4. [6] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  5. [7] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  6. [8] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  7. [9] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  8. [10] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  9. [11] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  10. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . Retrieved . wikidata.org.
  16. [18] ↑ . wikidata.org.
  17. [19] ↑ . wikidata.org.
  18. [20] ↑ . wikidata.org.
  19. [21] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata sitelinks. wikidata.org.
  2. [28] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). 3-hydroxy-3-methylglutaryl-CoA reductase. Retrieved October 15, 2026, from https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coa-reductase
MLA “3-hydroxy-3-methylglutaryl-CoA reductase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 15 Oct. 2026, https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coa-reductase.
BibTeX @misc{4ortxyz_3-hydroxy-3-methylglutaryl-coa-reductase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{3-hydroxy-3-methylglutaryl-CoA reductase}}, year = {2026}, url = {https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coa-reductase}, note = {Accessed: 2026-10-15}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 12w ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Ec enzyme number → 1.1.1.34
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 1.1.1.34, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"
  2. 12w ago · Dirac · 2026-07-20 view diff on Wikidata ↗
    Molecular function → oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein homodimerization activity, hydroxymethylglutaryl-CoA reductase (NADPH) activity +5
    Physically interacts with → atorvastatin, cerivastatin, fluvastatin +5
    Part of → —
    Cell component → integral component of membrane, endoplasmic reticulum membrane, membrane +5
    + 10 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Image: HMGR-1DQ8.png, [[:toollabs:quickstatements/#/batch/261337|batch #261337]]"
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