Tumor protein p53

mammalian protein found in Rattus norvegicus

Protein protein Q28563060

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Tumor protein p53

Summary

Tumor protein p53 is a protein^[1].

Key Facts

Tumor protein p53's instance of is recorded as protein^[2].
Tumor protein p53's subclass of is recorded as protein^[3].
Tumor protein p53's UniProt protein ID is recorded as P10361^[4].
Tumor protein p53's part of is recorded as p53-like transcription factor, DNA-binding^[5].
Tumor protein p53's part of is recorded as p53-like tetramerisation domain superfamily^[6].
Tumor protein p53's part of is recorded as p53/RUNT-type transcription factor, DNA-binding domain superfamily^[7].
Tumor protein p53's part of is recorded as p53 tumour suppressor family^[8].
Tumor protein p53's part of is recorded as p53 transactivation domain, protein family^[9].
Tumor protein p53's part of is recorded as p53, tetramerisation domain, protein family^[10].
Tumor protein p53's part of is recorded as p53, DNA-binding domain, protein family^[11].
Tumor protein p53's has part is recorded as p53, DNA-binding domain^[12].
Tumor protein p53's has part is recorded as p53, tetramerisation domain^[13].
Tumor protein p53's has part is recorded as p53 transactivation domain^[14].
Tumor protein p53's RefSeq protein ID is recorded as NP_112251^[15].
Tumor protein p53's RefSeq protein ID is recorded as XP_006246656^[16].
Tumor protein p53's RefSeq protein ID is recorded as XP_006246657^[17].
Tumor protein p53's RefSeq protein ID is recorded as XP_008765995^[18].
Tumor protein p53's RefSeq protein ID is recorded as XP_017452507^[19].
Tumor protein p53's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[20].
Tumor protein p53's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[21].
Tumor protein p53's molecular function is recorded as transcription coregulator binding^[22].
Tumor protein p53's molecular function is recorded as DNA binding^[23].
Tumor protein p53's molecular function is recorded as DNA-binding transcription factor activity^[24].
Tumor protein p53's molecular function is recorded as copper ion binding^[25].
Tumor protein p53's molecular function is recorded as protein binding^[26].

⭐ Popularity Graph

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Quick Facts

Instance of protein

Subclass of protein

Part of p53-like transcription factor, DNA-binding, p53-like tetramerisation domain superfamily, p53/RUNT-type transcription factor, DNA-binding domain superfamily, p53 tumour suppressor family, p53 transactivation domain, protein family, p53, tetramerisation domain, protein family, p53, DNA-binding domain, protein family

Properties

Biological process positive regulation of leukocyte migration, nucleotide-excision repair, regulation of transcription, DNA-templated, regulation of transcription by RNA polymerase II, apoptotic process, cellular response to DNA damage stimulus, response to oxidative stress, cell cycle, multicellular organism development, ageing, response to UV, response to inorganic substance, response to metal ion, response to X-ray, response to UV-B, response to organonitrogen compound, positive regulation of gene expression, programmed cell death, response to organic cyclic compound, negative regulation of cell growth, response to caffeine, response to retinoic acid, response to vitamin B3, response to cytokine, cellular response to heat, cellular response to reactive oxygen species, wound healing, positive regulation of apoptotic process, entrainment of circadian clock by photoperiod, response to amino acid, response to ethanol, positive regulation of cell cycle, negative regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, rhythmic process, circadian behavior, negative regulation of smooth muscle cell proliferation, protein tetramerization, regulation of intracellular pH, response to hyperoxia, cellular response to organonitrogen compound, positive regulation of release of cytochrome c from mitochondria, oligodendrocyte apoptotic process, regulation of hydrogen peroxide-induced cell death, negative regulation of DNA biosynthetic process, positive regulation of intrinsic apoptotic signaling pathway, negative regulation of transcription by RNA polymerase II, in utero embryonic development, somitogenesis, release of cytochrome c from mitochondria, T cell proliferation involved in immune response, B cell lineage commitment, T cell lineage commitment, response to ischemia, double-strand break repair, regulation of transcription by RNA polymerase II, protein import into nucleus, cellular response to DNA damage stimulus, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, response to oxidative stress, transforming growth factor beta receptor signaling pathway, gastrulation, negative regulation of neuroblast proliferation, central nervous system development, development of the heart, circadian rhythm, negative regulation of DNA replication, negative regulation of cell population proliferation, determination of adult lifespan, rRNA transcription, response to UV, response to salt stress, embryo development ending in birth or egg hatching, response to X-ray, response to gamma radiation, negative regulation of gene expression, positive regulation of cardiac muscle cell apoptotic process, cerebellum development, DNA damage response, signal transduction by p53 class mediator, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of histone deacetylation, mitotic G1 DNA damage checkpoint signaling, T cell differentiation in thymus, regulation of tissue remodeling, cellular response to UV, multicellular organism growth, positive regulation of mitochondrial membrane permeability, positive regulation of transcription from RNA polymerase II promoter in response to stress, regulation of cell population proliferation, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of apoptotic process, negative regulation of apoptotic process, entrainment of circadian clock by photoperiod, mitochondrial DNA repair, regulation of DNA damage response, signal transduction by p53 class mediator, regulation of neuron apoptotic process, positive regulation of neuron apoptotic process, negative regulation of proteolysis, negative regulation of transcription, DNA-templated, positive regulation of transcription, DNA-templated, negative regulation of mitotic cell cycle, positive regulation of transcription by RNA polymerase II, negative regulation of fibroblast proliferation, circadian behavior, embryonic organ development, positive regulation of peptidyl-tyrosine phosphorylation, protein stabilization, chromosome organization, neuron apoptotic process, regulation of cell cycle, interferon-gamma-mediated signaling pathway, cardiac septum morphogenesis, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, positive regulation of programmed necrotic cell death, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, regulation of thymocyte apoptotic process, positive regulation of thymocyte apoptotic process, necroptosis, cellular response to ionizing radiation, cellular response to gamma radiation, cellular response to UV-C, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of mitophagy, regulation of mitochondrial membrane permeability involved in apoptotic process, regulation of intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of production of miRNAs involved in gene silencing by miRNA, negative regulation of glucose catabolic process to lactate via pyruvate, intrinsic apoptotic signaling pathway in response to hypoxia, positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress, regulation of fibroblast apoptotic process, negative regulation of reactive oxygen species metabolic process, regulation of cellular senescence

Cell component chromatin, nucleus, transcription regulator complex, nucleolus, cytoplasm, mitochondrion, mitochondrial matrix, endoplasmic reticulum, cytosol, PML body, replication fork, cytosol, site of double-strand break

Encoded by Tp53

Found in taxon brown rat

Has part(s) p53, DNA-binding domain, p53, tetramerisation domain, p53 transactivation domain

Imported from wholeness_audit_2026-05-02

Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription coregulator binding, DNA binding, DNA-binding transcription factor activity, copper ion binding, protein binding, ATP binding, protein C-terminus binding, ubiquitin protein ligase binding, sequence-specific DNA binding, metal ion binding, MDM2/MDM4 family protein binding, promoter-specific chromatin binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, chromatin binding, ubiquitin protein ligase binding, histone deacetylase regulator activity, MDM2/MDM4 family protein binding

External References (3)

Ensembl protein id ENSRNOP00000074031, ENSRNOP00000075683, ENSRNOP00000047840, ENSRNOP00000068796, ENSRNOP00000075724, ENSRNOP00000080907, ENSRNOP00000089020, ENSRNOP00000092831

Refseq protein id NP_112251, XP_006246656, XP_006246657, XP_008765995, XP_017452507

Uniprot protein id P10361

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Tumor protein p53 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Tumor protein p53 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Tumor protein p53 — UniProt protein ID (P352): P10361. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Tumor protein p53 — part of (P361): p53-like transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Tumor protein p53 — part of (P361): p53-like tetramerisation domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Tumor protein p53 — part of (P361): p53/RUNT-type transcription factor, DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Tumor protein p53 — part of (P361): p53 tumour suppressor family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Tumor protein p53 — part of (P361): p53 transactivation domain, protein family. wikidata.org.
[10] ↑ Tumor protein p53 — part of (P361): p53, tetramerisation domain, protein family. wikidata.org.
[11] ↑ Tumor protein p53 — part of (P361): p53, DNA-binding domain, protein family. wikidata.org.
[12] ↑ Tumor protein p53 — has part(s) (P527): p53, DNA-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Tumor protein p53 — has part(s) (P527): p53, tetramerisation domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Tumor protein p53 — has part(s) (P527): p53 transactivation domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Tumor protein p53 — RefSeq protein ID (P637): NP_112251. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Tumor protein p53 — RefSeq protein ID (P637): XP_006246656. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Tumor protein p53 — RefSeq protein ID (P637): XP_006246657. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Tumor protein p53 — RefSeq protein ID (P637): XP_008765995. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Tumor protein p53 — RefSeq protein ID (P637): XP_017452507. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Tumor protein p53 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Tumor protein p53 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Tumor protein p53 — molecular function (P680): transcription coregulator binding. Analysis of p53 and NF-κB signaling in modulating the cardiomyocyte fate during hypertrophy. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Tumor protein p53 — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Tumor protein p53 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Tumor protein p53 — molecular function (P680): copper ion binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Tumor protein p53 — molecular function (P680): protein binding. Physical and functional interaction between WT1 and p53 proteins. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Tumor protein p53 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Tumor protein p53. Retrieved May 3, 2026, from https://4ort.xyz/entity/tumor-protein-p53-q28563060

MLA

“Tumor protein p53.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tumor-protein-p53-q28563060.

BibTeX

@misc{4ortxyz_tumor-protein-p53-q28563060_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Tumor protein p53}}, year = {2026}, url = {https://4ort.xyz/entity/tumor-protein-p53-q28563060}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Tumor protein p53 — https://4ort.xyz/entity/tumor-protein-p53-q28563060 (retrieved 2026-05-03)

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