SUFU negative regulator of hedgehog signaling

mammalian protein found in Homo sapiens

Protein protein Q21173255

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SUFU negative regulator of hedgehog signaling

Summary

SUFU negative regulator of hedgehog signaling is a protein^[1].

Key Facts

SUFU negative regulator of hedgehog signaling's instance of is recorded as protein^[2].
SUFU negative regulator of hedgehog signaling's subclass of is recorded as protein^[3].
SUFU negative regulator of hedgehog signaling's UniProt protein ID is recorded as Q9UMX1^[4].
SUFU negative regulator of hedgehog signaling's part of is recorded as Suppressor of fused, eukaryotic^[5].
SUFU negative regulator of hedgehog signaling's part of is recorded as Suppressor of fused, N-terminal^[6].
SUFU negative regulator of hedgehog signaling's part of is recorded as Suppressor of fused, C-terminal domain superfamily^[7].
SUFU negative regulator of hedgehog signaling's part of is recorded as Suppressor of fused-like domain, protein family^[8].
SUFU negative regulator of hedgehog signaling's part of is recorded as Suppressor of fused C-terminal domain, protein family^[9].
SUFU negative regulator of hedgehog signaling's has part is recorded as Suppressor of fused C-terminal^[10].
SUFU negative regulator of hedgehog signaling's has part is recorded as Suppressor of fused-like domain^[11].
SUFU negative regulator of hedgehog signaling's RefSeq protein ID is recorded as NP_001171604^[12].
SUFU negative regulator of hedgehog signaling's RefSeq protein ID is recorded as NP_057253^[13].
SUFU negative regulator of hedgehog signaling's RefSeq protein ID is recorded as XP_011538160^[14].
SUFU negative regulator of hedgehog signaling's RefSeq protein ID is recorded as XP_011538162^[15].
SUFU negative regulator of hedgehog signaling's RefSeq protein ID is recorded as XP_011538163^[16].
SUFU negative regulator of hedgehog signaling's RefSeq protein ID is recorded as XP_011538165^[17].
SUFU negative regulator of hedgehog signaling's RefSeq protein ID is recorded as XP_011538166^[18].
SUFU negative regulator of hedgehog signaling's RefSeq protein ID is recorded as XP_016871812^[19].
SUFU negative regulator of hedgehog signaling's PDB structure ID is recorded as 1M1L^[20].
SUFU negative regulator of hedgehog signaling's PDB structure ID is recorded as 4BL8^[21].
SUFU negative regulator of hedgehog signaling's PDB structure ID is recorded as 4BL9^[22].
SUFU negative regulator of hedgehog signaling's PDB structure ID is recorded as 4BLA^[23].
SUFU negative regulator of hedgehog signaling's PDB structure ID is recorded as 4BLB^[24].
SUFU negative regulator of hedgehog signaling's PDB structure ID is recorded as 4BLD^[25].
SUFU negative regulator of hedgehog signaling's PDB structure ID is recorded as 4KM8^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of Suppressor of fused, eukaryotic, Suppressor of fused, N-terminal, Suppressor of fused, C-terminal domain superfamily, Suppressor of fused-like domain, protein family, Suppressor of fused C-terminal domain, protein family

Properties

Biological process skeletal system development, regulation of transcription, DNA-templated, ventricular septum development, smoothened signaling pathway involved in ventral spinal cord interneuron specification, negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning, spinal cord dorsal/ventral patterning, negative regulation of transcription by RNA polymerase II, coronary vasculature development, negative regulation of DNA-binding transcription factor activity, negative regulation of osteoblast differentiation, proteolysis, heart looping, aorta development, neural tube closure, determination of left/right symmetry, smoothened signaling pathway involved in spinal cord motor neuron cell fate specification, negative regulation of ubiquitin-dependent protein catabolic process, signal transduction, skin development, multicellular organism development, cytoplasmic sequestering of transcription factor, negative regulation of protein import into nucleus, negative regulation of smoothened signaling pathway, negative regulation of DNA-binding transcription factor activity

Cell component cytosol, cilium, ciliary base, ciliary tip, nucleus, cytoplasm, nucleus, cytoplasm

Encoded by SUFU

Found in taxon Homo sapiens

Has part(s) Suppressor of fused C-terminal, Suppressor of fused-like domain

Imported from wholeness_audit_2026-05-02

Molecular function beta-catenin binding, transcription corepressor activity, transcription factor binding, signal transducer activity, protein binding, protein kinase binding, transcription factor binding

External References (4)

Ensembl protein id ENSP00000358915, ENSP00000358918, ENSP00000411597

Pdb structure id 1M1L, 4BL8, 4BL9, 4BLA, 4BLB, 4BLD, 4KM8, 4KM9, 4KMD, 4KMH

Refseq protein id NP_001171604, NP_057253, XP_011538160, XP_011538162, XP_011538163, XP_011538165, XP_011538166, XP_016871812

Uniprot protein id Q9UMX1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ SUFU negative regulator of hedgehog signaling — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ SUFU negative regulator of hedgehog signaling — subclass of (P279): protein. Q905695. Retrieved 2016-12-01. wikidata.org.
[4] ↑ SUFU negative regulator of hedgehog signaling — UniProt protein ID (P352): Q9UMX1. Q905695. Retrieved 2019-11-13. wikidata.org.
[5] ↑ SUFU negative regulator of hedgehog signaling — part of (P361): Suppressor of fused, eukaryotic. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ SUFU negative regulator of hedgehog signaling — part of (P361): Suppressor of fused, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ SUFU negative regulator of hedgehog signaling — part of (P361): Suppressor of fused, C-terminal domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ SUFU negative regulator of hedgehog signaling — part of (P361): Suppressor of fused-like domain, protein family. wikidata.org.
[9] ↑ SUFU negative regulator of hedgehog signaling — part of (P361): Suppressor of fused C-terminal domain, protein family. wikidata.org.
[10] ↑ SUFU negative regulator of hedgehog signaling — has part(s) (P527): Suppressor of fused C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ SUFU negative regulator of hedgehog signaling — has part(s) (P527): Suppressor of fused-like domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ SUFU negative regulator of hedgehog signaling — RefSeq protein ID (P637): NP_001171604. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ SUFU negative regulator of hedgehog signaling — RefSeq protein ID (P637): NP_057253. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ SUFU negative regulator of hedgehog signaling — RefSeq protein ID (P637): XP_011538160. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ SUFU negative regulator of hedgehog signaling — RefSeq protein ID (P637): XP_011538162. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ SUFU negative regulator of hedgehog signaling — RefSeq protein ID (P637): XP_011538163. Q20641742. Retrieved 2020-05-30. wikidata.org.
[17] ↑ SUFU negative regulator of hedgehog signaling — RefSeq protein ID (P637): XP_011538165. Q20641742. Retrieved 2020-05-30. wikidata.org.
[18] ↑ SUFU negative regulator of hedgehog signaling — RefSeq protein ID (P637): XP_011538166. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ SUFU negative regulator of hedgehog signaling — RefSeq protein ID (P637): XP_016871812. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ SUFU negative regulator of hedgehog signaling — PDB structure ID (P638): 1M1L. Q905695. Retrieved 2016-06-15. wikidata.org.
[21] ↑ SUFU negative regulator of hedgehog signaling — PDB structure ID (P638): 4BL8. Q905695. Retrieved 2016-06-15. wikidata.org.
[22] ↑ SUFU negative regulator of hedgehog signaling — PDB structure ID (P638): 4BL9. Q905695. Retrieved 2016-06-15. wikidata.org.
[23] ↑ SUFU negative regulator of hedgehog signaling — PDB structure ID (P638): 4BLA. Q905695. Retrieved 2016-06-15. wikidata.org.
[24] ↑ SUFU negative regulator of hedgehog signaling — PDB structure ID (P638): 4BLB. Q905695. Retrieved 2016-06-15. wikidata.org.
[25] ↑ SUFU negative regulator of hedgehog signaling — PDB structure ID (P638): 4BLD. Q905695. Retrieved 2016-06-15. wikidata.org.
[26] ↑ SUFU negative regulator of hedgehog signaling — PDB structure ID (P638): 4KM8. Q905695. Retrieved 2016-06-15. wikidata.org.

Class ancestry

[1] ↑ SUFU negative regulator of hedgehog signaling is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). SUFU negative regulator of hedgehog signaling. Retrieved May 3, 2026, from https://4ort.xyz/entity/sufu-negative-regulator-of-hedgehog-signaling

MLA

“SUFU negative regulator of hedgehog signaling.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/sufu-negative-regulator-of-hedgehog-signaling.

BibTeX

@misc{4ortxyz_sufu-negative-regulator-of-hedgehog-signaling_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{SUFU negative regulator of hedgehog signaling}}, year = {2026}, url = {https://4ort.xyz/entity/sufu-negative-regulator-of-hedgehog-signaling}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): SUFU negative regulator of hedgehog signaling — https://4ort.xyz/entity/sufu-negative-regulator-of-hedgehog-signaling (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/sufu-negative-regulator-of-hedgehog-signaling · Last refreshed: May 3, 2026